The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Stem cells in normal breast development and breast cancer
Open accessAbstract
Abstract. The main focus of this review is the role of mammary stem cells in normal breast development and carcinogenesis. We have developed a new in vitro culture system that permits, for the first time, the propagation of mammary stem and progenitor cells in an undifferentiated state, which should facilitate the elucidation of pathways that regulate normal mammary stem‐cell self‐renewal and differentiation. Furthermore, we propose a model in which transformation of stem cells, or early progenitor cells, results in carcinogenesis. A key event in this process is the deregulation of normal self‐renewal in these cells. Transformed mammary stem or progenitor cells undergo aberrant differentiation processes that result in generation of the phenotypic heterogeneity found in human and rodent breast cancers. This phenotypic diversity is driven by a small subset of mammary tumour stem cells. We will discuss the important implications of this mammary tumour stem‐cell model.
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Cites
Gene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280
Cited by
Tumour stem cells and drug resistance
Dean, M., Fojo, T., & Bates, S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1590 · Cited by 3,668
Cancer stem cells: an old idea–a paradigm shift
Wicha, M. S., Liu, S., & Dontu, G. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3153 · Cited by 1,378
Self-citationKucia, M., Reca, R., Miekus, K., Wanzeck, J., Wojakowski, W., Janowska‐Wieczorek, A., Ratajczak, J., & Ratajczak, M. Z. (2005) · STEM CELLS · doi:10.1634/stemcells.2004-0342 · Cited by 759
Pathogenesis of Triple-Negative Breast Cancer
Derakhshan, F., & Reis-Filho, J. S. (2022) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-042420-093238 · Cited by 714
Breast cancer: origins and evolution
Polyak, K. (2007) · Journal of Clinical Investigation · doi:10.1172/jci33295 · Cited by 697
Metadata
- Authors
- Dontu, G., Al‐Hajj, M., Abdallah, W. M., Clarke, M. F., & Wicha, M. S.
- Venue
- Cell Proliferation
- Publisher
- Wiley
- Published
- 2003-10
- Volume
- 36
- Issue
- s1
- Pages
- 59-72
- ISSN
- 0960-7722 (ISSN-L)
- 1365-2184
- OpenAlex
- W2762697978
- Cited by
- 578
- References
- 3
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Dontu, G., Al‐Hajj, M., Abdallah, W. M., Clarke, M. F., & Wicha, M. S. (2003). Stem cells in normal breast development and breast cancer. Cell Proliferation. https://doi.org/10.1046/j.1365-2184.36.s.1.6.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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