Cited by 248Systemic Lupus Erythematosus ResearchT-cell and B-cell ImmunologyRheumatoid Arthritis Research and Therapies

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Th1 (IL-2, interferon-gamma (IFN-γ)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)

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VIALLARD, J F, PELLEGRIN, J L, RANCHIN, V, SCHAEVERBEKE, T, DEHAIS, J, LONGY-BOURSIER, M, RAGNAUD, J M, LENG, B, MOREAU, J F·2001·Clinical and Experimental Immunology

DOI 10.1046/j.1365-2249.1999.00766.xPMC PMC1905189

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Abstract

SUMMARY: We investigated the production of IL-2, IFN-γ, IL-10 and IL-4 by PBMC from 24 patients with SLE and 10 healthy individuals. Basal and mitogen-stimulated (lipopolysaccharide and phytohaemagglutinin (LPS + PHA)) cytokine production was determined in a whole blood assay (WBA). Supernatants were collected and assayed with specific ELISAs. Although the IL-2 and IFN-γ contents did not differ significantly between patients and controls under both conditions, statistically significant correlations were found between each cytokine and disease activity (SLAM index) after stimulation (respectively, r= 0.501, P = 0.01 and r = 0.631, P = 0.001). PBMC IL-10 production was significantly higher for patients than controls (P = 0.05), but no correlation between IL-10 levels and the SLAM index was obtained. IL-4 production was not statistically different between SLE patients and controls. For stimulated WBAs, the IL-10/IL-2 and IL-10/IFN-γ ratios were significantly correlated with disease severity (P = 0.02; P = 0.001, respectively). Overall, our data suggest that SLE is characterized by an elevated production of IL-10, reflecting the basal state of activation of the immune system. During exacerbation of SLE, IL-2 and IFN-γ are synthesized in larger amounts and may cause the tissue damage observed.

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The 1982 revised criteria for the classification of systemic lupus erythematosus
Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., Mcshane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., & Winchester, R. J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780251101 · Cited by 14,519
TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
IL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888
Interleukin-10
Moore, K. W., O’Garra, A., Malefyt, R. D. W., Vieira, P., & Mosmann, T. R. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001121 · Cited by 1,883
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
Fiorentino, D. F., Zlotnik, A., Vieira, P., Mosmann, T. R., Howard, M., Moore, K. W., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.10.3444 · Cited by 1,866
Lymphokine Production by Human T Cells in Disease States
Romagnani, S. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001303 · Cited by 1,332
Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
Rousset, F., Garcia, E., Defrance, T., Péronne, C., Vezzio, N., Hsu, D. H., Kastelein, R., Moore, K. W., & Banchereau, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1890 · Cited by 1,238
Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI
Moore, K. W., Vieira, P., Fiorentino, D. F., Trounstine, M. L., Khan, T. A., & Mosmann, T. R. (1990) · Science · doi:10.1126/science.2161559 · Cited by 1,143
Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
Cherwinski, H., Schumacher, J., Brown, K., & Mosmann, T. (1987) · Journal of Experimental Medicine · doi:10.1084/jem.166.5.1229 · Cited by 1,118
Human TH1 and TH2 subsets: doubt no more
Romagnani, S. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90120-i · Cited by 1,079

Show all 48 references

Research works printed but not linked: 5

10.1146/annurev.immunol.7.1.145 · DOI · Paper page
Asherson RA, 1988, J Rheumatol, 15, 1742
Llorente L, 1993, Eur Cytokine Netw, 4, 421
10.1146/annurev.immunol.11.1.165 · DOI
Draeger AM, 1986, Clin Exp Immunol, 64, 80

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“Until recently, Th1 dominant immune responses have been generally considered to be pathological in autoimmune disease via the induction of inflammatory reaction, and large amounts of Th1 cytokines such as interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and IL-12 have been found in SLE [3,4].”
Background
A surface charge dependent enhanced Th1 antigen-specific immune response in lymph nodes by transfersome-based nanovaccine-loaded dissolving microneedle-assisted transdermal immunization
Wu, X., Li, Y., Chen, X., Zhou, Z., Pang, J., Luo, X., & Kong, M. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00448c · Cited by 62
T cell receptor repertoire of T cells in the kidneys of patients with lupus nephritis
村田, 秀., Matsumura, R., Kôyama, A., Sugiyama, T., Sueishi, M., Shibuya, K., Tsutsumi, A., & Sumida, T. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10432 · Cited by 57
Immunomodulatory effect of exo-polysaccharides from submerged cultured Cordyceps sinensis: enhancement of cytokine synthesis, CD11b expression, and phagocytosis
Kuo, M.-C., Chang, C.-Y., Cheng, T.-L., & Wu, M. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-0880-5 · Cited by 56
“In peripheral blood, not only is the natural cell–cell interactions preserved but also circulating stimulatory and inhibitory mediators are present at their physiological concentrations (Viallard et al. 1999).”
Background
High-intensity interval training can modulate the systemic inflammation and HSP70 in the breast cancer: a randomized control trial
Alizadeh, A. M., Isanejad, A., Sadighi, S., Mardani, M., Kalaghchi, B., & Hassan, Z. M. (2019) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-019-02996-y · Cited by 56
Immunomodulatory effects of Yun Zhi and Danshen capsules in health subjects—a randomized, double-blind, placebo-controlled, crossover study
Wong, C. K., Tse, P. S., Wong, E. L., Leung, P. C., Fung, K., & Lam, C. W. K. (2003) · International Immunopharmacology · doi:10.1016/j.intimp.2003.12.003 · Cited by 55
Patients with Systemic Lupus Erythematosus
Byun (1999) · American family physician · Cited by 53
Immunoregulation of NKT Cells in Systemic Lupus Erythematosus
Chen, J., Wu, M. C., Wang, J., & Li, X. (2015) · Journal of Immunology Research · doi:10.1155/2015/206731 · Cited by 52
“The imbalance between Th1 and Th2 cytokines participates in the immunoregulation of SLE [29, 40].”
Background
Incidence of Autoantibodies Against Type I and Type II Interferons in a Cohort of Systemic Lupus Erythematosus Patients in Slovakia
Slavíková, M., Schmeisser, H., Kontseková, E., Mateička, F., Borecky, L., & KONTSEK, P. (2003) · Journal of Interferon & Cytokine Research · doi:10.1089/107999003321532475 · Cited by 51
MIF promotes a differential Th1/Th2/Th17 inflammatory response in human primary cell cultures: Predominance of Th17 cytokine profile in PBMC from healthy subjects and increase of IL-6 and TNF-α in PBMC from active SLE patients
la Cruz-Mosso, U. D., García‐Iglesias, T., Bucala, R., Estrada‐García, I., González-López, L., Cerpa‐Cruz, S., Parra‐Rojas, I., Gámez-Nava, J. I., Pérez-Guerrero, E. E., & Muñóz-Valle, J. F. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.12.010 · Cited by 51
The effect of immunosuppressive therapy on the messenger RNA expression of target genes in the urinary sediment of patients with active lupus nephritis
Chan, R. W. Y., Lai, F. M., Li, E. K., Tam, L., Chow, K., Li, P. K., & Szeto, C. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfk102 · Cited by 47
Cathepsin S inhibition suppresses autoimmune-triggered inflammatory responses in macrophages
Thanei, S., Theron, M., Silva, A. P., Reis, B., Branco, L., Schirmbeck, L. A., Kolb, F. A., Haap, W. J., Schindler, T. H., & Trendelenburg, M. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.10.001 · Cited by 46
Avian pathogenic Escherichia coli (APEC) infection alters bone marrow transcriptome in chickens
Sun, H., Liu, P., Nolan, L. K., & Lamont, S. J. (2015) · BMC Genomics · doi:10.1186/s12864-015-1850-4 · Cited by 45
Interleukin 4 and STAT6 gene polymorphisms are associated with systemic lupus erythematosus in Chinese patients
Yu, H., Liu, P., Lin, Y., Chen, W. J., Lee, J., Wang, L., Yang, Y., & Chiang, B. (2010) · Lupus · doi:10.1177/0961203310371152 · Cited by 44
Stage Dependent Aberrant Regulation of Cytokine-STAT Signaling in Murine Systemic Lupus Erythematosus
Hale, M. B., Krutzik, P. O., Samra, S. S., Crane, J., & Nolan, G. P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006756 · Cited by 45
Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway
Zhang, Y., Li, Z., Wu, H., Wang, J., & Zhang, S. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115004 · Cited by 43
The Function of CD3+CD56+NKT-Like Cells in HIV-Infected Individuals
Jiang, Y., Cui, X., Chen, C., Zhang, J., Zhou, F., Zhang, Z., Fu, Y., Xu, J., Chu, Z., Liu, J., et al. (2014) · BioMed Research International · doi:10.1155/2014/863625 · Cited by 43
BAFF-R and TACI expression on CD3+ T cells: Interplay among BAFF, APRIL and T helper cytokines profile in systemic lupus erythematosus
Salazar‐Camarena, D. C., Ortiz‐Lazareno, P. C., Marín‐Rosales, M., Cruz, Á., Muñoz‐Valle, F., Tapia‐Llanos, R., Orozco‐Barocio, G., Machado-Contreras, J. R., & Palafox‐Sánchez, C. A. (2018) · Cytokine · doi:10.1016/j.cyto.2018.11.008 · Cited by 42
Macrophages and neutrophils in SLE—An online molecular catalog
Orme, J. J., & Mohan, C. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.10.010 · Cited by 42
“Contrary to its classical designation as an anti-inflammatory cytokine, IL-10 contributes directly to SLE pathogenesis.”
BackgroundInfluential
The effect of interleukin-10 and of interleukin-12 on the in vitro production of anti-double-stranded DNA antibodies from patients with systemic lupus erythematosus
Tyrrell-Price, J., Lydyard, P. M., & Isenberg, D. A. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01466.x · Cited by 42
Clinical Studies of Immunomodulatory Activities of Yunzhi-Danshen in Patients with Nasopharyngeal Carcinoma
Bao, Y. X., Wong, C. K., Leung, S. F., Chan, A. T. �., Li, P. W., Wong, E. L., Leung, P., Fung, K., Yin, Y. B., & Lam, C. W. K. (2006) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2006.12.771 · Cited by 41
Interferon-γ polymorphisms in systemic lupus erythematosus
Lee, J., GOLDMAN, D. W., Piliero, L. M., Petri, M., & Sullivan, K. E. (2001) · Genes and Immunity · doi:10.1038/sj.gene.6363775 · Cited by 41
Activation of Peripheral Th17 Lymphocytes in Patients with Asthma
Wong, C. K., Lun, S. W., Ko, F. W. S., Wong, P. T. Y., Hu, S. Q., Chan, I. H.-S., Hui, D. S. C., & Lam, C. W. K. (2009) · Immunological Investigations · doi:10.1080/08820130903062756 · Cited by 40
Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects
Arora, V., Verma, J., Marwah, V., Kumar, A., Anand, D., & Das, N. (2012) · Lupus · doi:10.1177/0961203311434937 · Cited by 40
Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling
Yang, X., Sun, B., Wang, H., Cheng, Y., Xiaole, W., & Ji, X. (2015) · Journal of Biomedical Research · doi:10.7555/jbr.29.20130037 · Cited by 39
The CXCR4–STAT3–IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide
Shaim, H., Estrov, Z. E., Harris, D., Sanabria, M. H., Liu, Z., Ruvolo, P. P., Thompson, P. A., Ferrajoli, A., Daher, M., Burger, J. A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01773 · Cited by 38
Sulfated Mesona chinensis Benth polysaccharide enhance the immunomodulatory activities of cyclophosphamide-treated mice
Shen, M., Chen, X., Huang, L., Yu, Q., Chen, Y., & Xie, J. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104321 · Cited by 39
Immunological tolerance loss vs. erythrocyte self antigens and cytokine network disregulation in autoimmune hemolytic anaemia
Fagiolo, E. (2003) · Autoimmunity Reviews · doi:10.1016/s1568-9972(03)00085-5 · Cited by 38
Aberrant Expression of Soluble Co-stimulatory Molecules and Adhesion Molecules in Type 2 Diabetic Patients with Nephropathy
Wong, C. K., Ho, A. M. ‐., Tong, P. C. Y., Yeung, C. Y., Chan, J. C. N., Kong, A. P. S., & Lam, C. W. K. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9137-4 · Cited by 38
Immunological alterations in newly diagnosed primary Sjögren's syndrome characterized by skewed peripheral T‐cell subsets and inflammatory cytokines
Szodoray, P., Gál, I., Baráth, S., Aleksza, M., Horváth, I. F., Gergely, P., Szegedi, G., Nakken, B., & Zeher, M. (2008) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740801910361 · Cited by 38
“IL-10 and IFN-c levels depend strongly on the level of immune activation in patients with autoimmune diseases (38).”
Background
Interleukin-12 inhibits pathological neovascularization in mouse model of oxygen-induced retinopathy
Zhou, Y., Yoshida, S., Kubo, Y., Kobayashi, Y., Nakama, T., Yamaguchi, M., Ishikawa, K., Nakao, S., Ikeda, Y., Ishibashi, T., et al. (2016) · Scientific Reports · doi:10.1038/srep28140 · Cited by 38
The role of interleukins 4, 17 and interferon gamma as biomarkers in patients with Systemic Lupus Erythematosus and their correlation with disease activity
Elewa, E. A., Zakaria, O., Mohamed, E. I., & Boghdadi, G. (2013) · The Egyptian Rheumatologist · doi:10.1016/j.ejr.2013.10.003 · Cited by 37
Inhibition of Lupus by Genetic Alteration of the Interferon-α/β Receptor
Kono, D. H., Baccalà, R., & Theofilopoulos, A. N. (2003) · Autoimmunity · doi:10.1080/08916930310001624665 · Cited by 37
IL-10 and the Cytokine Network in the Pathogenesis of Human Autoimmune Hemolytic Anemia
Toriani-Terenzi, C., & Fagiolo, E. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1361.044 · Cited by 37
Amidase, a cell wall hydrolase, elicits protective immunity against Staphylococcus aureus and S. epidermidis
Nair, N., Vinod, V., Suresh, M. K., Vijayrajratnam, S., Biswas, L., Peethambaran, R., Vasudevan, A. K., & Biswas, R. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.03.047 · Cited by 36
Changes in Serum Cytokines May Predict Therapeutic Efficacy of Tofacitinib in Rheumatoid Arthritis
Li, Y., Yuan, L., Yang, J. W., Lei, Y., Zhang, H., Xia, L., Shen, H., & Lu, J. (2019) · Mediators of Inflammation · doi:10.1155/2019/5617431 · Cited by 37
“CD4+Th lymphocytes can be divided into Th1 (IFN-γ, IL-2, and TNF-β) and Th2 (IL-4, IL-6, IL-10, and IL-13) subsets on the basis of their cytokines secretion profile [15].”
Background
Lupus patients with pulmonary involvement have a pro-inflammatory cytokines profile
Al-Mutairi, S., Al-Awadhi, A. M., Raghupathy, R., Al-Khawari, H., Sada, P. N., Al-Herz, A. A., & Rawoot, P. (2006) · Rheumatology International · doi:10.1007/s00296-006-0268-3 · Cited by 36
Increased lipid and protein oxidation and lowered anti-oxidant defenses in systemic lupus erythematosus are associated with severity of illness, autoimmunity, increased adhesion molecules, and Th1 and Th17 immune shift
Scavuzzi, B. M., Simão, A. N. C., Iriyoda, T. M. V., Lozovoy, M. A. B., Stadtlober, N. P., Santos, L. F. D. R. F., Flauzino, T., de Medeiros, F. A., de Sá, M. C., Consentin, L., et al. (2017) · Immunologic Research · doi:10.1007/s12026-017-8960-9 · Cited by 35
Increased percentages of PD-1 on CD4+T cells is associated with higher INF-γ production and altered IL-17 production in patients with systemic lupus erythematosus
Dolff, S., Quandt, D., Feldkamp, T., Jun, C., Mitchell, A., Hua, F., Specker, C., Kribben, A., Witzke, O., & Wilde, B. (2014) · Scandinavian Journal of Rheumatology · doi:10.3109/03009742.2013.869830 · Cited by 35

Authors: VIALLARD, J. F., PELLEGRIN, J. L., RANCHIN, V, SCHAEVERBEKE, T., DEHAIS, J., LONGY-BOURSIER, M., RAGNAUD, J. M., LENG, B., & MOREAU, J. F.
Affiliations: Centre National de la Recherche Scientifique (FR)
Hôpital Cardiologique du Haut-Lévêque (FR)
Laboratoire Immunotech, Marseille
Hôpital Pellegrin (FR)
Service de Médecine Interne, Hôpital Saint-André
Corresponding author: VIALLARD, J F
ORCID: VIALLARD, J F
PELLEGRIN, J L
SCHAEVERBEKE, T
MOREAU, J F
Venue: Clinical and Experimental Immunology
Publisher: Oxford University Press (OUP)
Published: 1999-01
Volume: 115
Issue: 1
Pages: 189-195
ISSN: 0009-9104 (ISSN-L)
1365-2249
DOI: 10.1046/j.1365-2249.1999.00766.x
PMC: PMC1905189
OpenAlex: W2030175762
Cited by: 247
References: 48
Citations by year: 2026: 8 · 2025: 9 · 2024: 8 · 2023: 13 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 12 · 2015: 11 · 2014: 16 · 2013: 4 · 2012: 13
FWCI: 6.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Clinical & Experimental Immunology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: systemic lupus erythematosus, Th1/Th2 balance, interleukin-2, interferon-gamma, IL-10, IL-4, peripheral blood mononuclear cells, disease activity, cytokine ratios, immune activation, tissue damage
MeSH terms: Adolescent, Adult, Female, Humans, Interferon-gamma, Interleukin-2, Leukocytes, Mononuclear, Lupus Erythematosus, Systemic, Male, Middle Aged, Interleukin-4, Cytokines, Interleukin-10, Th1 Cells, Th2 Cells

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Th1 (IL-2, interferon-gamma (IFN-γ)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)

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