The DOI matches its Crossref record, with a small difference in title or year; 49 of the 49 references it cites were found in a registry or an index.
Th1 (IL-2, interferon-gamma (IFN-γ)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)
Open accessAbstract
SUMMARY: We investigated the production of IL-2, IFN-γ, IL-10 and IL-4 by PBMC from 24 patients with SLE and 10 healthy individuals. Basal and mitogen-stimulated (lipopolysaccharide and phytohaemagglutinin (LPS + PHA)) cytokine production was determined in a whole blood assay (WBA). Supernatants were collected and assayed with specific ELISAs. Although the IL-2 and IFN-γ contents did not differ significantly between patients and controls under both conditions, statistically significant correlations were found between each cytokine and disease activity (SLAM index) after stimulation (respectively, r= 0.501, P = 0.01 and r = 0.631, P = 0.001). PBMC IL-10 production was significantly higher for patients than controls (P = 0.05), but no correlation between IL-10 levels and the SLAM index was obtained. IL-4 production was not statistically different between SLE patients and controls. For stimulated WBAs, the IL-10/IL-2 and IL-10/IFN-γ ratios were significantly correlated with disease severity (P = 0.02; P = 0.001, respectively). Overall, our data suggest that SLE is characterized by an elevated production of IL-10, reflecting the basal state of activation of the immune system. During exacerbation of SLE, IL-2 and IFN-γ are synthesized in larger amounts and may cause the tissue damage observed.
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“In adaptative immune regulation, •NO inhibits the lymphocytes T helper 1 (Th1 is a population characterized by the release of IL-2 and IFN-γ) and promotes Th2 lymphocytes, which leads to humoral immunity and allergic responses [113].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [113]
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IL-10 inhibits cytokine production by activated macrophages
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Wong, C. K., Lit, L. C. W., Tam, L., Li, E. K. M., Wong, P. T. Y., & Lam, C. W. K. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.01.019 · Cited by 535
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Cytokine IL-6 and IL-10 as Biomarkers in Systemic Lupus Erythematosus
Chun, H.-Y., Chung, J.-W., Kim, H., Yun, J., Jeon, J., Ye, Y., Kim, S., Park, H., & Suh, C. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9104-0 · Cited by 390
“Concentrations of IFN-γ are increased in SLE patients, and the production of IFN-γ by PBMCs from SLE patients is significantly correlated with global disease activity [13, 29].”
Background
Metadata
- Authors
- VIALLARD, J. F., PELLEGRIN, J. L., RANCHIN, V, SCHAEVERBEKE, T., DEHAIS, J., LONGY-BOURSIER, M., RAGNAUD, J. M., LENG, B., & MOREAU, J. F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Hôpital Cardiologique du Haut-Lévêque (FR)
- Laboratoire Immunotech, Marseille
- Hôpital Pellegrin (FR)
- Service de Médecine Interne, Hôpital Saint-André
- Corresponding author
- VIALLARD, J F
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01
- Volume
- 115
- Issue
- 1
- Pages
- 189-195
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- PMC
- PMC1905189
- OpenAlex
- W2030175762
- Cited by
- 247
- References
- 48
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 8 · 2023: 13 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 12 · 2015: 11 · 2014: 16 · 2013: 4 · 2012: 13
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical & Experimental Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- systemic lupus erythematosus, Th1/Th2 balance, interleukin-2, interferon-gamma, IL-10, IL-4, peripheral blood mononuclear cells, disease activity, cytokine ratios, immune activation, tissue damage
- MeSH terms
- Adolescent, Adult, Female, Humans, Interferon-gamma, Interleukin-2, Leukocytes, Mononuclear, Lupus Erythematosus, Systemic, Male, Middle Aged, Interleukin-4, Cytokines, Interleukin-10, Th1 Cells, Th2 Cells
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