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Cited by 135Sexual Differentiation and DisordersAdrenal Hormones and DisordersOvarian function and disorders

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Mothers with congenital adrenal hyperplasia and their children: outcome of pregnancy, birth and childhood

Krone, Nils, Wachter, Isolde, Stefanidou, Marianna, Roscher, Adelbert A., Schwarz, Hans Peter·2001·Clinical Endocrinology
DOI 10.1046/j.1365-2265.2001.01359.x
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Abstract

OBJECTIVES Fertility rates in women with congenital adrenal hyperplasia (CAH) are reported to be poor, but few data are available. We assessed rates and course of pregnancy, mode of delivery and long‐term outcome of offspring from women with CAH. DESIGN A large cohort of women with CAH due to 21‐hydroxylase deficiency had initially been diagnosed and followed at one centre. Those women who had given birth were contacted. Information was gathered from hospital records, direct patient contact, structured questionnaire and the Documentation of Pregnancy and Preventive Care Booklets. RESULTS Between 1978 and 1998, 18 women with CAH (one salt wasting, 12 simple virilizing, five nonclassical) had given birth to 31 children (18 females, 13 males). Delivery was by Caesarean section in 16 out of the 31 children. None of the female newborns was masculinized. Twenty‐nine children were born at term, five children were small for gestational age (SGA). Postnatal development was basically normal in all children; 18 are now older than 10 years, seven are between 5 and 10 years old, six are less than 5 years old. CONCLUSIONS Fertility is reduced in females with CAH, especially those with the severe or salt wasting phenotype. In those women with CAH who do conceive, course and outcome of pregnancy is mostly uneventful, although the rate of SGA offspring may be increased. Psychomotor and somatic long‐term development of the children was within normal limits.

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Crossref · 10.1046/j.1365-2265.2001.01359.x

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Research works printed but not linked: 4

  1. 10.1210/jc.82.2.479 · DOI
  2. 10.1210/jc.84.6.1844 · DOI · Paper page
  3. Murset G., 1970, Male external genitalia of a girl caused by a virilizing adrenal tumour in the mother. Case report and steroid studies, Acta Endocrinologica Supplement (Copenhagen), 65, 627
  4. 10.1210/er.21.3.245 · DOI

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Metadata

Authors
Krone, N., Wachter, I., Stefanidou, M., Roscher, A. A., & Schwarz, H. P.
Affiliations
  • Ludwig-Maximilians-Universität München (DE)
  • Technische Universität Dresden (DE)
Corresponding author
Schwarz, Hans Peter
ORCID
Krone, Nils
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2001-10
Volume
55
Issue
4
Pages
523-529
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1046/j.1365-2265.2001.01359.x
OpenAlex
W2043812370
Cited by
135
References
33
Citations by year
2025: 1 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 56 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 6 · 2012: 3
FWCI
0.46
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2471 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
congenital adrenal hyperplasia, 21-hydroxylase deficiency, maternal fertility, pregnancy outcomes, mode of delivery, cesarean section, small for gestational age, salt-wasting phenotype, non-classical congenital adrenal hyperplasia
MeSH terms
Adrenal Hyperplasia, Congenital, Cesarean Section, Child, Child Development, Child, Preschool, Female, Glucocorticoids, Humans, Infant, Newborn, Infant, Small for Gestational Age, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Retrospective Studies

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