Cited by 218Sexual Differentiation and DisordersBirth, Development, and HealthAdrenal Hormones and Disorders

Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: results of a pilot study

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Trautman, Paul D., Meyer-Bahlburg, Heino F.L., Postelnek, Jill, New, Maria I.·1995·Psychoneuroendocrinology

Abstract

The effect of early prenatal dexamethasone (DEX) exposure on cognitive and behavioral development, behavior problems, and temperament were examined in 26 consecutively identified children aged 6 mo to 5 1/2 years, whose mothers had been DEX-treated during pregnancy because their offspring was at risk for congenital adrenal hyperplasia (CAH), and compared with 14 children from untreated CAH-risk pregnancies. Three children in each group were CAH-affected. Assessments were performed by way of mother-completed standard questionnaires. No significant differences in cognitive abilities or behavior problems were identified. On temperament questionnaires, DEX-exposed children showed more Shyness (p < .004), greater Emotionality (p < .03), less Sociability (p < .04), and a trend for greater Avoiddance (p < .07) than unexposed children. DEX-exposed children also had significantly higher Internalizing (p < .002) and Total Problem scores (p < .05) on the behavior problem measure for 2-3 year olds. The results should be considered preliminary until they have been replicated by the study of a larger sample and direct examination of the children.

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Crossref · 10.1016/0306-4530(94)00070-0

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  • Other adverse events including failure to thrive, stroke-like events and midline defects have been observed in both short-term and full-term treated cases at risk for CAH.

    “Other adverse events including failure to thrive, stroke-like events and midline defects have been observed in both shortterm and full-term treated cases at risk for CAH (472-474).”

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Authors
Trautman, P. D., Meyer-Bahlburg, H. F. L., Postelnek, J., & New, M. I.
Affiliations
Cornell University (US)
Corresponding author
Trautman, Paul D.
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
1995
Volume
20
Issue
4
Pages
439-449
ISSN
0306-4530 (ISSN-L)
OpenAlex
W2021131551
Cited by
217
References
45
Citations by year
2024: 9 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 15
FWCI
1.60
Type
journal article
Language
en
Open access
Locations
  • Psychoneuroendocrinology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
prenatal dexamethasone, congenital adrenal hyperplasia, prenatal glucocorticoid exposure, child cognitive development, child behavior problems, temperament, internalizing problems, shyness, sociability, emotionality, avoidance behavior, young children
MeSH terms
Adrenal Hyperplasia, Congenital, Child, Child Behavior, Child Development, Child, Preschool, Cognition, Dexamethasone, Female, Humans, Infant, Maternal-Fetal Exchange, Pilot Projects, Pregnancy, Prenatal Exposure Delayed Effects, Surveys and Questionnaires, Risk Factors

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