Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: results of a pilot study
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The effect of early prenatal dexamethasone (DEX) exposure on cognitive and behavioral development, behavior problems, and temperament were examined in 26 consecutively identified children aged 6 mo to 5 1/2 years, whose mothers had been DEX-treated during pregnancy because their offspring was at risk for congenital adrenal hyperplasia (CAH), and compared with 14 children from untreated CAH-risk pregnancies. Three children in each group were CAH-affected. Assessments were performed by way of mother-completed standard questionnaires. No significant differences in cognitive abilities or behavior problems were identified. On temperament questionnaires, DEX-exposed children showed more Shyness (p < .004), greater Emotionality (p < .03), less Sociability (p < .04), and a trend for greater Avoiddance (p < .07) than unexposed children. DEX-exposed children also had significantly higher Internalizing (p < .002) and Total Problem scores (p < .05) on the behavior problem measure for 2-3 year olds. The results should be considered preliminary until they have been replicated by the study of a larger sample and direct examination of the children.
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Other adverse events including failure to thrive, stroke-like events and midline defects have been observed in both short-term and full-term treated cases at risk for CAH.
“Other adverse events including failure to thrive, stroke-like events and midline defects have been observed in both shortterm and full-term treated cases at risk for CAH (472-474).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [473]
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- Authors
- Trautman, P. D., Meyer-Bahlburg, H. F. L., Postelnek, J., & New, M. I.
- Affiliations
- Cornell University (US)
- Corresponding author
- Trautman, Paul D.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 1995
- Volume
- 20
- Issue
- 4
- Pages
- 439-449
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2021131551
- Cited by
- 217
- References
- 45
- Citations by year
- 2024: 9 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 15
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Psychoneuroendocrinology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- prenatal dexamethasone, congenital adrenal hyperplasia, prenatal glucocorticoid exposure, child cognitive development, child behavior problems, temperament, internalizing problems, shyness, sociability, emotionality, avoidance behavior, young children
- MeSH terms
- Adrenal Hyperplasia, Congenital, Child, Child Behavior, Child Development, Child, Preschool, Cognition, Dexamethasone, Female, Humans, Infant, Maternal-Fetal Exchange, Pilot Projects, Pregnancy, Prenatal Exposure Delayed Effects, Surveys and Questionnaires, Risk Factors
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