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Cited by 221Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid Surgery

Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency.

Pedersen, Inge Bülow, Knudsen, Nils, Jørgensen, Torben, Perrild, Hans, Ovesen, Lars, Laurberg, Peter·2003·Clinical Endocrinology
DOI 10.1046/j.1365-2265.2003.01633.x
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Abstract

BACKGROUND AND AIMS: Autoimmune thyroiditis is one of the most common autoimmune disorders. Autoantibodies against the thyroid gland, with thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (Tg-Ab) as the most common autoantibodies, can often be demonstrated in serum in population surveys. In the present study we evaluated if TPO-Ab and Tg-Ab tend to develop in parallel or whether one or the other may be more prevalent in subsets of the population. METHODS: In a cross-sectional comparative study, performed in two areas of Denmark with mild and moderate iodine deficiency, 4649 randomly selected subjects in age groups between 18 and 65 years were examined. Blood tests were analysed for TPO-Ab and Tg-Ab using assays based on the radioimmunoassay (RIA) technique. The participants answered questionnaires, were clinically examined and had urine samples collected. RESULTS: The overall prevalence rate of thyroid autoantibodies (TPO-Ab and/or Tg-Ab) was 18.8%. The prevalence rates of TPO-Ab and Tg-Ab were similar (13.1 vs. 13.0%). Both antibodies were more frequent in females than in males, and in females the prevalence rates increased with age. In the age group 60-65 years thyroid antibodies were more frequently measured in sera from moderate than from mild iodine-deficient area (P = 0.02), whereas no differences were seen in younger subjects. In 38.8% of participants with thyroid autoantibodies in serum, both antibodies were present. In sera with both TPO-Ab and Tg-Ab present the concentrations of the antibodies were generally higher than in sera with only one type of antibody present. CONCLUSION: The prevalence rates of TPO-Ab and Tg-Ab were similar in this large population survey. The results suggest that TPO-Ab and Tg-Ab predominantly develop due to a general alteration in the immune system, whereas specific antigenic mechanisms are probably of less importance. However, further studies are needed to clarify the mechanisms involved in the development of thyroid autoantibodies.

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  • Measuring thyroid peroxidase or antithyroglobulin antibodies is not recommended for the diagnosis of primary hypothyroidism because the prevalence of thyroid antibody test positivity ranges from 5% to 20% in individuals without hypothyroidism.

    “Measuring thyroid peroxidase or antithyroglobulin antibodies is not recommended for the diagnosis of primary hypothyroidism because the prevalence of thyroid antibody test positivity ranges from5%to20%inindividualswithouthypothyroidism. 55,56”

    From Hypothyroidism: A Review (2025) · cites this paper as [55]

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Authors
Pedersen, I. B., Knudsen, N., Jørgensen, T., Perrild, H., Ovesen, L., & Laurberg, P.
Affiliations
  • Aalborg University Hospital (DK)
  • Bispebjerg Hospital (DK)
  • Glostrup Hospital (DK)
Corresponding author
Pedersen, Inge Bülow
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2003-01
Volume
58
Issue
1
Pages
36-42
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1046/j.1365-2265.2003.01633.x
OpenAlex
W2125320223
Cited by
221
References
36
Citations by year
2026: 6 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 13 · 2021: 16 · 2020: 12 · 2019: 12 · 2018: 11 · 2017: 7 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 12
FWCI
6.71
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
thyroid peroxidase antibodies, thyroglobulin antibodies, thyroid autoantibodies, autoimmune thyroiditis, iodine deficiency, prevalence, sex differences, age differences
MeSH terms
Adolescent, Adult, Aged, Autoantibodies, Cross-Sectional Studies, Denmark, Female, Health Surveys, Humans, Iodide Peroxidase, Iodine, Male, Middle Aged, Thyroglobulin, Thyroiditis, Autoimmune, Prevalence, Age Distribution

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