CoChat
Sign Up
Cited by 195Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryThyroid Cancer Diagnosis and Treatment

Epidemiology of subtypes of hypothyroidism in Denmark.

Carlé, Allan, Laurberg, Peter, Pedersen, Inge Bülow, Knudsen, Nils, Perrild, Hans, Ovesen, Lars, Rasmussen, Lone Banke, Jorgensen, Torben·2006·European Journal of Endocrinology
DOI 10.1530/eje.1.02068
Open this paper in CoChat — free account

Abstract

OBJECTIVE: Studies of hypothyroidism are often based on referred patients, and limited information is available on the incidence rates of subtypes of hypothyroidism in the general population. We therefore studied incidences of subtypes of primary, overt hypothyroidism in a Danish population cohort and compared incidences in two subcohorts with different levels of iodine intake. DESIGN: A prospective population-based study, monitoring a well-defined cohort representative of the Danish population. METHODS: The Danish Investigation of Iodine Intake and Thyroid Diseases registry of hyper- and hypothyroidism was established as part of the monitoring of the iodine fortification of salt in Denmark. A computer-based system linked to laboratory databases identified all patients diagnosed with new, biochemically overt hypothyroidism in populations living in Aalborg (moderate iodine deficiency, n = 311,102) and Copenhagen (mild iodine deficiency, n = 227,632). We subsequently evaluated all identified patients to verify incident thyroid disease, and subclassified hypothyroidism into nosological types. RESULTS: During a 4-year period (2,027,208 person-years) 685 new cases of overt hypothyroidism were diagnosed in the cohort; the incidence rate was 32.8 per 100,000 person-years (standardised to the Danish population). Nosological types of hypothyroidism were: spontaneous (presumably autoimmune) 84.4%, post-partum 4.7%, amiodarone-associated 4.0%, subacute thyroiditis 1.8%, previous radiation or surgery 1.8%, congenital 1.6% and lithium-associated 1.6%. Crude incidence rates were 29.0 around Aalborg and 40.6 in an area of Copenhagen. The higher incidence rate of hypothyroidism in the area with higher iodine intake was caused solely by more cases of spontaneous (presumably autoimmune) hypothyroidism, whereas the incidence of non-spontaneous hypothyroidism (all types combined) was significantly lower in the area with higher iodine intake. CONCLUSION: In a population-based study we observed a higher incidence of hypothyroidism with higher iodine intake. This was due solely to the entity of spontaneous hypothyroidism. The occurrence of overt hypothyroidism was relatively low in Denmark.

Integrity signals

Registry

Crossref · 10.1530/eje.1.02068

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Hashimoto thyroiditis is the cause of primary hypothyroidism in up to 85% of patients with hypothyroidism living in areas with adequate nutritional iodine levels.

    “Hashimoto thyroiditis (an autoimmune disease) is the cause of primary hypothyroidism in up to 85% of patients with hypothyroidism living in areas with adequate nutritional iodine levels. 9”

    From Hypothyroidism: A Review (2025) · cites this paper as [9]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Carlé, A., Laurberg, P., Pedersen, I. B., Knudsen, N., Perrild, H., Ovesen, L., Rasmussen, L. B., & Jorgensen, T.
Affiliations
  • Aalborg University Hospital (DK)
  • Bispebjerg Hospital (DK)
  • Hjerteforeningen (DK)
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2006-01
Volume
154
Issue
1
Pages
21-28
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje.1.02068
OpenAlex
W2121837488
Cited by
195
References
34
Citations by year
2026: 8 · 2025: 9 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 10 · 2020: 3 · 2019: 13 · 2018: 11 · 2017: 12 · 2016: 13 · 2015: 14 · 2014: 11 · 2013: 12 · 2012: 14
FWCI
3.31
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
Funders
Bispebjerg Hospital
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
hypothyroidism, overt hypothyroidism, incidence, iodine intake, iodine deficiency, autoimmune hypothyroidism, nosological classification, postpartum hypothyroidism, amiodarone-induced hypothyroidism, subacute thyroiditis, population-based cohort
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Autoantibodies, Child, Child, Preschool, Denmark, Female, Humans, Hypothyroidism, Infant, Infant, Newborn, Iodide Peroxidase, Iodine, Male, Middle Aged, Prospective Studies, Puerperal Disorders, Registries, Sex Factors, Cohort Studies, Incidence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review