Effects of low‐dose l‐arginine on insulin‐mediated vasodilatation and insulin sensitivity

WASCHER, T. C.; GRAIER, W. F.; DITTRICH, P.; HUSSAIN, M. A.; BAHADORI, B.; WALLNER, S.; TOPLAK, H.

doi:10.1046/j.1365-2362.1997.1730718.x

Cited by 87Nitric Oxide and Endothelin EffectsDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Health and Disease Prevention

Effects of low‐dose l‐arginine on insulin‐mediated vasodilatation and insulin sensitivity

WASCHER, T. C., GRAIER, W. F., DITTRICH, P., HUSSAIN, M. A., BAHADORI, B., WALLNER, S., TOPLAK, H.·1997·European Journal of Clinical Investigation

DOI 10.1046/j.1365-2362.1997.1730718.x

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Abstract

The present study was carried out to evaluate the effect of a low-dose intravenous supplementation of L-arginine on insulin-mediated vasodilatation and insulin sensitivity. The study was performed in healthy subjects (n = 7) and patients with obesity (n = 9) and non-insulin-dependent diabetes mellitus (NIDDM) (n = 9). Insulin-mediated vasodilatation was measured by venous occlusion plethysmography during the insulin suppression test, evaluating insulin sensitivity. Experiments were performed twice in each subject in the presence or absence of a concomitant infusion of L-arginine (0.52 mg kg-1 min-1). L-Arginine restored the imparied insulin-mediated vasodilatation observed in obesity (22.4 +/- 4.1%, P < 0.01 vs. without L-arginine) and NIDDM (20.3 +/- 3.2%, P < 0.01 vs. without L-arginine). In healthy subjects, no effect on insulin mediated-vasodilatation was observed (24.8 +/- 3.1% vs. 21.4 +/- 3.1%). Insulin sensitivity was improved significantly (P < 0.001) in all three groups by infusion of L-arginine. No effect of L-arginine was observed on insulin, insulin-like growth factor I (IGF-I), free fatty acids (FFAs) or C-peptide levels during the insulin suppression test. Our data indicate that defective insulin-mediated vasodilatation in obesity and NIDDM can be normalized by intravenous L-arginine. Furthermore, L-arginine improves insulin sensitivity in obese patients and NIDDM patients as well as in healthy subjects, indicating a possible mechanism that is different from the restoration of insulin-mediated vasodilatation.

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Human studies have repeatedly shown that L-arginine supplementation has favorable effects on body composition and insulin sensitivity.
“However, human studies have repeatedly shown that L-arginine supplementation has favorable effects on body composition and insulin sensitivity [271-277].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [271]

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“However, in the insulin suppression test, the researchers observed no change in insulin, IGF-1, free fatty acids and C-peptide [66].”
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Background
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“Wascher [69] Intravenous infusion, 0.”
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Background
Oral arginine does not stimulate an increase in insulin concentration but delays glucose disposal,,
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Background
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“[10] Wascher TC, Graier WF, Dittrich P, et al.”
Background
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Vasdev, S., & Gill, V. D. (2008) · International Journal of Angiology · doi:10.1055/s-0031-1278274 · Cited by 53 · see citing works
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Cook, S., & Scherrer, U. (2002) · Fundamental and Clinical Pharmacology · doi:10.1046/j.1472-8206.2002.00130.x · Cited by 44 · see citing works
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Effects of chelator treatment on aorta and corpus cavernosum from diabetic rats
Keegan, A., Cotter, M. A., & Cameron, N. E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00125-2 · Cited by 37 · see citing works
L-arginine supplementation and risk factors of cardiovascular diseases in healthy men: a double-blind randomized clinical trial
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“There is evidence that long-term L-arginine intake can increase insulin sensitivity and improve the glycemic indices 28 .”
Reverse Correlation between Urine Nitric Oxide Metabolites and Insulin Resistance in Patients with Type 2 Diabetes Mellitus.
Kurioka, S., Koshimura, K., Murakami, Y., Nishiki, M., & Kato, Y. (2000) · Endocrine Journal · doi:10.1507/endocrj.47.77 · Cited by 33 · see citing works
L-arginine supplementation and risk factors of cardiovascular diseases in healthy men: a double-blind randomized clinical trial
Pahlavani, N., Jafari, M., Rezaei, M., Rasad, H., Sadeghi, O., Rahdar, H. A., & Entezari, M. H. (2014) · F1000Research · doi:10.12688/f1000research.5877.1 · Cited by 30 · see citing works
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Tay, A., Ozcelikay, A. T., & ALTAN, V. M. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02231-2 · Cited by 27 · see citing works
Antiobesogenic Role of Endothelial Nitric Oxide Synthase
Sansbury, B. E., & Hill, B. G. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800254-4.00013-1 · Cited by 25 · see citing works
Supplementation of L-arginine improves hypertension and lipid metabolism but not insulin resistance in diabetic rats
Kawano, T., Nomura, M., Nisikado, A., Nakaya, Y., & Ito, S. (2003) · Life Sciences · doi:10.1016/j.lfs.2003.06.004 · Cited by 25 · see citing works
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Halperin, F., Mezza, T., Li, P., et al. (2022) · Metabolism · doi:10.1016/j.metabol.2021.155117 · Cited by 24 · see citing works
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de Luis, D. A., Izaola, O., de la Fuente, B., & Aller, R. (2014) · PubMed · doi:10.3305/nh.2014.30.4.7864 · Cited by 14 · see citing works
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Jobgen, W. S., Lee, M., Fried, S. K., & Wu, G. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221139207 · Cited by 14 · see citing works
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Wallin, M. K. E. B., Selldén, E., Eksborg, S., & Brismar, K. (2007) · Nutrition & Metabolism · doi:10.1186/1743-7075-4-2 · Cited by 12 · see citing works
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BackgroundMethod
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Parkhitko, A. A., & Cracan, V. (2025) · Science Advances · doi:10.1126/sciadv.adu1710 · Cited by 15 · see citing works
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Vasdev, S., Gill, V. D., Randell, E. W., Han, Y., & Gadag, V. G. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0281-4 · Cited by 11 · see citing works
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Xing, M., Gao, H., Yao, L., Wang, L., Zhang, C., Zhu, L., & Cui, D. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1190954 · Cited by 9 · see citing works
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Karimi, E., Hatami, E., Ghavami, A., Hadi, A., Darand, M., & Askari, G. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1863991 · Cited by 9 · see citing works
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Feng, Y., Ji-tao, L., Yang, J., et al. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6130-2_32 · Cited by 9 · see citing works
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Panić, A., Stanimirović, J., Obradovic, M. M., Sudar-Milovanovic, E. M., Perović, M., Lačković, M., Petrović, N., & Isenović, E. R. (2018) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1680 · Cited by 9 · see citing works
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Escudero, A. C., Petzold, G., Moreno, J. J., González, M., Junod, J., Aguayo, C. R., Acurio, J., & Escudero, C. (2013) · BioFactors · doi:10.1002/biof.1103 · Cited by 7 · see citing works
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Background
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Maxwell, A. J., & Cooke, J. P. (2003) · Humana Press eBooks · doi:10.1385/1-59259-002-0:547 · Cited by 7 · see citing works
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Albaugh, V. L., Stewart, M. K., & Barbul, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805376-8.00027-7 · Cited by 6 · see citing works
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Monti, L. D., Galluccio, E., Fontana, B., Bosi, E., & Piatti, P. (2016) · Springer eBooks · doi:10.1007/978-3-319-26009-9_32 · Cited by 3 · see citing works
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Chaisanguanthum, R., & Tayek, J. A. (2003) · Nutrition Research · doi:10.1016/s0271-5317(02)00481-5 · Cited by 3 · see citing works
Advances in diabetes for the millennium: nutritional therapy of type 2 diabetes.
Rendell, M. S. (2004) · PubMed Central · Cited by 3 · see citing works
Relevance and Safe Utilization of Amino Acids in Supplements for Human Nutrition: Lessons from Clinical and Preclinical Studies
Blachier, F. (2026) · Nutrients · doi:10.3390/nu18020296 · Cited by 5 · see citing works
“Lastly, intravenous infusion of arginine in obese individuals improved insulin sensitivity and restored the insulin-mediated vasodilatation [158].”
Arginine Supplementation in Cardiovascular Disorders
Fried, R. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-420046-3.00007-x · Cited by 2 · see citing works
Dysfunkcja śródbłonka i ADMA w patogenezie nadciśnienia tętniczego Endothelial dysfunction and ADMA in pathogenesis of arterial hypertension
Doroszko, A., Andrzejak, R., & Szuba, A. (2008) · Cited by 2 · see citing works
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Al‐Masoudi, W. A., Al-Diwan, M. A., & Khayoon, O. S. (2016) · European Journal of Chemistry · doi:10.5155/eurjchem.7.3.280-282.1431 · Cited by 2 · see citing works
Nitric Oxide (Prong-2)
DePace, N. L., & Colombo, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-17016-5_4 · Cited by 2 · see citing works
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Wallin, M. K. E. B. (2007) · Figshare · Cited by 2 · see citing works
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Korchowiec, M., Bialic, Ł., Mądrzak, L., Krzyżanowska, K., Chrzanowski, W., Kwiecińska, J., Hryniuk, W., Sitkiewicz, J., Toczyłowska, A., & Muras, M. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(47).2025.3442 · Cited by 1 · see citing works
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Bandt, J. P. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-810422-4.00018-x · Cited by 1 · see citing works
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Pasquale, M. D. D. (2007) · Nutrition in exercise and sport · doi:10.1201/9781420043815.ch8
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Bezrukov, V. V., Sykalo, N. V., Kuprash, L., & Panteleymonova, T. (2022) · Ageing & Longevity · doi:10.47855/jal9020-2022-4-1 · Cited by 1 · see citing works
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Artham, S. M., Patel, D. A., Lavie, C. J., Milani, R. V., & O’Keefe, J. H. (2022) · Springer eBooks · doi:10.1007/978-0-387-85960-6_14 · Cited by 1 · see citing works
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(1998) · Alternative and Complementary Therapies · doi:10.1089/act.1998.4.141
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Authors: WASCHER, T. C., GRAIER, W. F., DITTRICH, P., HUSSAIN, M. A., BAHADORI, B., WALLNER, S., & TOPLAK, H.
Affiliations: University of Graz (AT)
University Hospital Zurich (CH)
Corresponding author: WASCHER, T. C.
ORCID: GRAIER, W. F.
HUSSAIN, M. A.
WALLNER, S.
TOPLAK, H.
Venue: European Journal of Clinical Investigation
Publisher: Wiley
Published: 1997-08
Volume: 27
Issue: 8
Pages: 690-695
ISSN: 0014-2972 (ISSN-L)
1365-2362
DOI: 10.1046/j.1365-2362.1997.1730718.x
OpenAlex: W1978337405
Cited by: 87
References: 0
Citations by year: 2026: 2 · 2025: 2 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 3 · 2014: 7 · 2013: 5 · 2012: 6
FWCI: 2.24
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2280 d)
Locations: European Journal of Clinical Investigation (publishedVersion)
PubMed (publishedVersion)
Funders: Oesterreichische Nationalbank
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: L-arginine, insulin sensitivity, obesity, type 2 diabetes, insulin resistance, intravenous supplementation, insulin suppression test, insulin-like growth factor I, free fatty acids, C-peptide
MeSH terms: Adult, Arginine, C-Peptide, Diabetes Mellitus, Type 2, Fatty Acids, Female, Humans, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Male, Middle Aged, Obesity, Vasodilation

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Effects of low‐dose l‐arginine on insulin‐mediated vasodilatation and insulin sensitivity

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