Cited by 77Muscle metabolism and nutritionCardiovascular and exercise physiologyExercise and Physiological Responses

L-Citrulline Reduces Time to Exhaustion and Insulin Response to a Graded Exercise Test

HICKNER, ROBERT C., TANNER, CHARLES J., EVANS, CHRIS A., CLARK, PAIGE D., HADDOCK, AMY, FORTUNE, CHRIS, GEDDIS, HEATHER, WAUGH, WILLIAM +1 more·2006·Medicine & Science in Sports & Exercise

Abstract

PURPOSE: Oral L-arginine supplementation has been shown to improve treadmill time to exhaustion and resting insulin sensitivity in individuals with peripheral vascular disease and type 2 diabetes, respectively. Furthermore, L-citrulline supplementation increases plasma L-arginine concentration to a level higher than that achieved by oral L-arginine supplementation. The purpose of this investigation was therefore to determine whether time to exhaustion during a graded treadmill test, as well as plasma insulin and glucose profiles, could be improved with oral L-citrulline supplementation in healthy individuals. METHODS: Seventeen young (18-34 yr), healthy male and female volunteers performed incremental treadmill tests to exhaustion following either placebo or citrulline ingestion (3 g 3 h before test, or 9 g over 24 h prior to testing). RESULTS: Steady-state submaximal respiratory exchange ratio and VO2max were not significantly different between placebo and citrulline trials. Treadmill time to exhaustion was lower following citrulline ingestion than during placebo trials (888.2 +/- 17.7 vs 895.4 +/- 17.9 s; P < 0.05; N = 17), which was accompanied by a higher rating of perceived exertion during exercise in the L-citrulline compared with the placebo condition. There was also an increase in plasma insulin in response to this high-intensity exercise in the placebo, but not in the L-citrulline, condition (P < 0.05). CONCLUSIONS: It can be concluded that, contrary to the hypothesized improvement in treadmill time following L-citrulline ingestion, there is a reduction in treadmill time following L-citrulline ingestion over the 24 h prior to testing. The normal response of increased plasma insulin following high-intensity exercise is also not present in the L-citrulline condition, indicating that L-citrulline ingestion may reduce nitric oxide-mediated pancreatic insulin secretion or increased insulin clearance.

Integrity signals

Registry

Crossref · 10.1249/01.mss.0000210197.02576.da

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
HICKNER, R. C., TANNER, C. J., EVANS, C. A., CLARK, P. D., HADDOCK, A., FORTUNE, C., GEDDIS, H., WAUGH, W., & MCCAMMON, M.
Affiliations
East Carolina University (US)
Venue
Medicine & Science in Sports & Exercise
Published
2006-04
Volume
38
Issue
4
Pages
660-666
ISSN
0195-9131 (ISSN-L)
OpenAlex
W2050457522
Cited by
77
References
30
Citations by year
2026: 2 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 8 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 4
FWCI
0.55
Type
journal article
Language
en
Open access
closed
Locations
  • Medicine & Science in Sports & Exercise (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
L-citrulline supplementation, L-arginine, time to exhaustion, graded treadmill exercise, plasma insulin response, high-intensity exercise, nitric oxide, insulin secretion, insulin clearance, rating of perceived exertion, VO2max, respiratory exchange ratio
MeSH terms
Adolescent, Adult, Analysis of Variance, Blood Glucose, Citrulline, Exercise Test, Female, Humans, Insulin, Male, Plasma Volume, Anaerobic Threshold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review