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Cited by 97Cardiovascular and exercise physiologyNitric Oxide and Endothelin EffectsExercise and Physiological Responses

Contribution of nitric oxide to exercise‐induced changes in healthy volunteers: effects of acute exercise and long‐term physical training

POVEDA, J. J., RIESTRA, A., SALAS, E., CAGIGAS, M. L., LÓPEZ‐SOMOZA, C., AMADO, J. A., BERRAZUETA, J. R.·1997·European Journal of Clinical Investigation
DOI 10.1046/j.1365-2362.1997.2220763.x
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Abstract

Endothelium plays a central role in the regulation of regional blood flow through the release of certain vasoactive substances. We conducted this study to test whether an increase in the production of nitric oxide (NO) metabolites, atrial natriuretic peptide (ANP) and plasma and intraplatelet cyclic guanosine 3′:5′ monophosphate (cGMP) is involved in the adaptation to chronic exercise in physically trained people and in the vasodilatation induced by acute physical exercise. We studied one group of 10 trained athletes and another group of 10 untrained people. We measured plasma levels of nitrites, nitrates and cGMP and intraplatelet levels of cGMP, as an indicator of intracellular guanylate cyclase activity, and ANP before and after a maximal treadmill test. Resting cardiac rate (CR) and systolic blood pressure (SBP) were lower in the athlete group than in the control group (73.8 ± 3.6 vs. 92 ± 5.9; P < 0.02 and 110 ± 2.58 vs. 118 ± 3.27; P < 0.02 respectively). SBP did not show differences between groups after the exercise test. Diastolic blood pressure (DBP) at rest was lower in the athlete group (71 ± 1.79 vs. 80.5 ± 3.53; P < 0.03) and the decrease after maximal exercise was more pronounced in this group (64 ± 2.67 vs. 74.5 ± 3.2; P < 0.02). Basal plasma nitrites were 4.9 ± 0.8 in the athlete group and 1.9 ± 0.3 in the control group (P < 0.05). After exercise, test differences between groups remained (P < 0.05). Nitrates were significantly higher in the group of athletes and did not show exercise‐related changes. Plasma levels of cGMP and ANP increased in both groups after the treadmill test, with no differences between groups. Among the athletes, cGMP increased from 1.11 ± 0.1 to 2.6 ± 0.4 (P < 0.001), whereas in the untrained group plasma cGMP rose from 1.14 ± 0.09 to 1.86 ± 0.2 (P < 0.01). There was a significant correlation between the increases in plasma cGMP and the atrial natriuretic peptide in both groups (r = 0.91, P < 0.0002, for athletes; and r = 0.68, P < 0.04, for control group). The intraplatelet concentration of cGMP did not show differences between groups and did not change after exercise. In conclusion, we have found increased basal levels of plasma nitrite and nitrate in trained subjects. Exercise does not produce differences in the increments of these metabolites. Therefore, we speculate the release of nitric oxide is not augmented by exercise in trained athletes.

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  • Highly trained subjects may have higher plasma nitrite values than sedentary or lesser trained subjects, such that the response to a standard dose of nitrate may be diminished.

    “Moreover, highly trained subjects may have higher plasma [nitrite] values than sedentary or lesser trained subjects [57], such that the response to a standard dose of nitrate may be diminished.”

    From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [57]

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Authors
POVEDA, J. J., RIESTRA, A., SALAS, E., CAGIGAS, M. L., LÓPEZ‐SOMOZA, C., AMADO, J. A., & BERRAZUETA, J. R.
Affiliations
Universidad de Cantabria (ES)
Corresponding author
POVEDA, J. J.
ORCID
AMADO, J. A.
Venue
European Journal of Clinical Investigation
Publisher
Wiley
Published
1997-11
Volume
27
Issue
11
Pages
967-971
ISSN
  • 0014-2972 (ISSN-L)
  • 1365-2362
DOI
10.1046/j.1365-2362.1997.2220763.x
OpenAlex
W1981601912
Cited by
97
References
0
Citations by year
2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 8
FWCI
9.13
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2215 d)
Locations
  • European Journal of Clinical Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
nitric oxide, acute exercise, athletes, atrial natriuretic peptide, cyclic GMP, endothelium, nitrite, nitrate, blood pressure, heart rate, treadmill exercise, exercise adaptation, guanylate cyclase, regional blood flow regulation, nitric oxide metabolites
MeSH terms
Cyclic AMP, Adult, Blood Pressure, Female, Heart Rate, Humans, Male, Atrial Natriuretic Factor, Nitrates, Nitric Oxide, Nitrites, Physical Education and Training, Vasodilation, Exercise

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