Cited by 73Thyroid Disorders and TreatmentsBlood properties and coagulationHormonal and reproductive studies

Low serum thyrotropin is associated with high plasma fibrinogen

Dörr, Marcus, Robinson, Daniel M., Wallaschofski, Henri, Schwahn, Christian, John, Ulrich, Felix, Stephan B., Völzke, Henry·2006·The Journal of Clinical Endocrinology & Metabolism

Abstract

BACKGROUND: Elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular events. Decreased serum TSH predicts vascular mortality, which hypothetically could be explained in part by alterations in the blood coagulation system. OBJECTIVE: The objective of this study was to investigate the association between thyroid function and plasma fibrinogen levels in a general population. DESIGN: The population-based Study of Health in Pomerania was performed in a previously iodine-deficient area in Germany, including 4310 subjects, aged 20-79 yr. Data for 3804 individuals without thyroid disease were analyzed. Analysis revealed an association between thyroid function status and plasma fibrinogen concentration. RESULTS: Elevated fibrinogen levels (>3.25 g/liter) were observed in 14 subjects with increased serum TSH levels (32.6%), 973 euthyroid subjects (28.9%), 158 subjects with decreased serum TSH levels (40.7%), and six individuals with overt hyperthyroidism (54.4%). Logistic regression analysis revealed decreased serum TSH as an independent risk factor for elevated fibrinogen levels (odds ratio, 1.42; 95% confidence interval, 1.12-1.80). CONCLUSIONS: Thyroid function is associated with plasma fibrinogen. Decreased serum TSH is an independent risk factor for elevated plasma fibrinogen levels as a possible explanation for the high cardiovascular mortality among affected subjects.

Integrity signals

Registry

Crossref · 10.1210/jc.2005-1786

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Overt and subclinical hyperthyroidism are associated with increased markers of thrombogenesis, including fibrinogen and factor X levels.

    “Overt and SHyper have been associated with increased markers of thrombogenesis (fibrinogen and factor X levels) (58,59).”

    From Thyroid Hormones and Cardiovascular Function and Diseases (2018) · cites this paper as [58]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Dörr, M., Robinson, D. M., Wallaschofski, H., Schwahn, C., John, U., Felix, S. B., & Völzke, H.
Affiliations
  • Departments of Internal Medicine B (M.D., D.M.R., S.B.F.), D-17487 Greifswald, Germany.
  • Universitätsmedizin Greifswald (DE)
  • Universität Greifswald (DE)
  • Institute of Epidemiology and Social Medicine (U.J., H.V.), Ernst Moritz Arndt University, D-17487 Greifswald, Germany.
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2006-02-01
Volume
91
Issue
2
Pages
530-534
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W2105216713
Cited by
73
References
25
Citations by year
2025: 1 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 6
FWCI
3.40
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
thyroid-stimulating hormone, fibrinogen, thyroid function, hyperthyroidism, cardiovascular risk, coagulation, iodine deficiency, cardiovascular mortality, Study of Health in Pomerania
MeSH terms
Adult, Aged, Female, Fibrinogen, Humans, Male, Middle Aged, Thyroid Gland, Thyrotropin, Thyroxine, Triiodothyronine, Multivariate Analysis, Logistic Models

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review