Cited by 569Circadian rhythm and melatoninDietary Effects on HealthSleep and Work-Related Fatigue

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Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus

Hara, Reiko, Wan, Keiko, Wakamatsu, Hisanori, Aida, Reiko, Moriya, Takahiro, Akiyama, Masashi, Shibata, Shigenobu·2001·Genes to Cells

DOI 10.1046/j.1365-2443.2001.00419.x

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Abstract

BACKGROUND: There are two main stimuli that entrain the circadian rhythm, the light-dark cycle (LD) and restricted feeding (RF). Light-induced entrainment requires induction of the Per1 and Per2 genes in the suprachiasmatic nucleus (SCN), the locus of a main oscillator. In this experiment, we determined whether RF resets the expression of circadian clock genes in the mouse liver with or without participation of the SCN. RESULTS: Mice were allowed access to food for 4 h during the daytime (7 h advance of feeding time) under LD or constant darkness (DD). The peaks of mPer1, mPer2, D-site-binding protein (Dbp) and cholesterol 7alpha-hydroxylase (Cyp7A) mRNA in the liver were advanced 6-12 h after 6 days of RF, whereas those in SCN were unaffected. The advance of mPer expression in the liver by RF was still observed in SCN-lesioned mice. A 7 h advance in the LD cycle advanced the peaks of clock gene expression in both the liver and SCN, whereas, a shift in the LD did not move the phase of the liver clock when the shift was carried out under a fixed RF schedule during the night-time. CONCLUSIONS: These results suggest that restricted feeding strongly entrained the expression of circadian clock genes in the liver without the participation of an SCN clock function.

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Time memory for heat exposure limited to a fixed daily time in heat-acclimated rats and humans
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Light phase feeding and estradiol reverse ovariectomy-induced alterations in metabolism and liver clock gene expression in rat
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“Indeed, the timing of food intake can cause a complete phase shift in the circadian clocks, an event well-described in the liver of male rodens (Damiola et al. 2000; Stokkan et al. 2001; Hara et al. 2001; Vollmers et al. 2009; Salgado-Del-gado et al. 2013; Manella et al. 2021).”
Glucocorticoid-dependence and independence of the circadian liver transcriptome
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“Here the preserved rhythmicity of the Per genes in the absence of GR, despite being glucocorticoid-responsive genes, likely re ﬂ ects the sensitivity of Per1/2 to other systemic cues (e.g. feeding time, insulin action 47,48 ).”
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“Tahara et al. showed that 12 h of RF at night could synchronize the peripheral clocks of SCN-lesioned mice, including kidney function [20].”
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“[27] When fed with a high-fat diet (HFD), the activity pattern, clock-related genes, nuclear receptor, and clock-related genes were all changed in mice.”
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“Under this feeding protocol, the 24-h rhythmicity is entrained mainly by the time of food accessibility, the molecular clock in the liver being one of the first to respond to this condition (Hara et al. 2001).”
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“, food restriction) (Stokkan et al., 2001; Hara et al., 2001), as well as changes in food composition (i.”
Background
Chrono-nutrition and n-3 polyunsaturated fatty acid
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“Some earlier studies reported that SCN lesioning completely abolished the rhythm of Per2 in the liver of rats (Sakamoto et al. 1998) and mice (Hara et al. 2001), but these studies only compared two time points, which is insufficient to assess rhythmicity accurately.”
Background
Neurobioloy of sleep and circadian disorders
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“…established that time-restricted feeding/intermittent fasting cycles impact and can reset secondary tissue-specific peripheral clocks independent of the master circadian clock that is generally phase-locked to light-dark cycles ( Damiola et al., 2000 ; Hara et al., 2001 ; Stokkan et al., 2001 ).”
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“Similarly, restricted feeding to the light phase changes circadian oscillations in the mouse liver but not the SCN 48-50 .”
Background
Searching for Order in Body Clocks: Circadian Rhythms and Redox Balance
del Olmo, M. (2021) · Logos Verlag Berlin eBooks · doi:10.30819/5406 · Cited by 1
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Circadian patterns of antioxidant and lipid peroxidation status in daytime food restricted rats
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“Moreover, phase advances of molecular oscillations within the liver in response to daytime restricted feeding still occur in SCN-lesioned mice (Hara et al. 2001).”
Background
Modification of Energy Metabolism and Higher Brain Function by Feeding Rhythm
Otsuka, A., & Shiuchi, T. (2018) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.18-00091-7 · Cited by 1
4’-demethylnobiletin-rich fermented Citrus reticulata (ponkan) attenuated the disturbance in clock gene expression and locomotor activity rhythms caused by high-fat diet feeding
Haraguchi, A., Sato, S., Kusano, S., Ito, K., Yamazaki, T., Ryan, C., Sekiguchi, M., & Shibata, S. (2021) · Biological Rhythm Research · doi:10.1080/09291016.2021.1968609 · Cited by 1
“Peripheral clocks can be organized not only by the central clock, but also by environmental stimuli, such as feeding, temperature, and stress (Hara et al. 2001; Ohnishi et al. 2014; Tahara et al. 2015).”
Background

Authors: Hara, R., Wan, K., Wakamatsu, H., Aida, R., Moriya, T., Akiyama, M., & Shibata, S.
Affiliations: Waseda University (JP)
Corresponding author: Shibata, Shigenobu
ORCID: Shibata, Shigenobu
Venue: Genes to Cells
Publisher: Wiley
Published: 2001-03
Volume: 6
Issue: 3
Pages: 269-278
ISSN: 1356-9597 (ISSN-L)
1365-2443
DOI: 10.1046/j.1365-2443.2001.00419.x
OpenAlex: W1965036088
Cited by: 569
References: 28
Citations by year: 2026: 12 · 2025: 12 · 2024: 17 · 2023: 20 · 2022: 27 · 2021: 24 · 2020: 24 · 2019: 18 · 2018: 23 · 2017: 36 · 2016: 20 · 2015: 29 · 2014: 26 · 2013: 21 · 2012: 29
FWCI: 5.94
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2685 d)
Locations: Genes to Cells (publishedVersion)
PubMed (publishedVersion)
Funders: Ministerul Cercetării, Inovării şi Digitalizării
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: feed restriction, circadian entrainment, liver clock, suprachiasmatic nucleus, clock genes, Per1, Per2, DBP, SCN lesions, light-dark cycle, constant darkness
MeSH terms: Animals, Biological Clocks, Feeding Methods, Gene Expression Regulation, Liver, Male, Nuclear Proteins, Suprachiasmatic Nucleus, Transcription Factors, Cell Cycle Proteins, Mice, Period Circadian Proteins

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Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus

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