Cited by 569Circadian rhythm and melatoninDietary Effects on HealthSleep and Work-Related Fatigue

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Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus

Hara, Reiko, Wan, Keiko, Wakamatsu, Hisanori, Aida, Reiko, Moriya, Takahiro, Akiyama, Masashi, Shibata, Shigenobu·2001·Genes to Cells

DOI 10.1046/j.1365-2443.2001.00419.x

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Abstract

BACKGROUND: There are two main stimuli that entrain the circadian rhythm, the light-dark cycle (LD) and restricted feeding (RF). Light-induced entrainment requires induction of the Per1 and Per2 genes in the suprachiasmatic nucleus (SCN), the locus of a main oscillator. In this experiment, we determined whether RF resets the expression of circadian clock genes in the mouse liver with or without participation of the SCN. RESULTS: Mice were allowed access to food for 4 h during the daytime (7 h advance of feeding time) under LD or constant darkness (DD). The peaks of mPer1, mPer2, D-site-binding protein (Dbp) and cholesterol 7alpha-hydroxylase (Cyp7A) mRNA in the liver were advanced 6-12 h after 6 days of RF, whereas those in SCN were unaffected. The advance of mPer expression in the liver by RF was still observed in SCN-lesioned mice. A 7 h advance in the LD cycle advanced the peaks of clock gene expression in both the liver and SCN, whereas, a shift in the LD did not move the phase of the liver clock when the shift was carried out under a fixed RF schedule during the night-time. CONCLUSIONS: These results suggest that restricted feeding strongly entrained the expression of circadian clock genes in the liver without the participation of an SCN clock function.

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Background
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BackgroundInfluential
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Result
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“…oscillators (Yoo et al., 2004; Stratmann and Schibler, 2006), we have decided to focus on liver and heart, since these tissues are commonly studied in mammalian systems, where they have been shown to be regulated autonomously from SCN (Damiola et al., 2000; Hara et al., 2001; Stokkan et al., 2001).”
Background
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Background
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BackgroundInfluential
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Background
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Background
Nature's food anticipatory experiment: entrainment of locomotor behavior, suprachiasmatic and dorsomedial hypothalamic nuclei by suckling in rabbit pups
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Background
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Background
FEEDING-INDUCED RAPID RESETTING OF THE HEPATIC CIRCADIAN CLOCK IS ASSOCIATED WITH ACUTE INDUCTION OFPER2ANDDEC1TRANSCRIPTION IN RATS
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“In rodents, daytime restricted feeding (RF) can entrain the circadian clock of many peripheral tissues and some extra-SCN brain regions independent of the SCN clock (Damiola et al., 2000; Hara et al., 2001; MinanaSolis et al., 2009; Stokkan et al., 2001; Wakamatsu et al., 2000).”
Background
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Background
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Background
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“schedules, the SCN pacemaker does not invert its phase [8–10].”
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Background
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“By contrast, the profiles in the liver were completely phase-inverted as previously reported [15,16,17], which denoted that the liver clock was preferentially entrained by feeding-associated cues rather than light-related cues, whereas the response of the pituitary clock appeared more complex.”
BackgroundInfluential
Time-Restricted Feeding Alters the Innate Immune Response to Bacterial Endotoxin
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Background
The Impact of Time of Day on Energy Expenditure: Implications for Long-Term Energy Balance
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“phase of the SCN clock still matches that of the light-dark cycle [41-43].”
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“After 5 days of the shift, when rats were left in DD and with food ad libitum, we observed that in the RFS-S group, the phase of the free-running rhythm started at the phase achieved after 5 days in the new cycle, suggesting a corresponding shift of the SCN.”
BackgroundInfluential
Daily rhythms of lipid metabolic gene expression in zebra fish liver: Response to light/dark and feeding cycles
Paredes, J. F., López‐Olmeda, J. F., Martínez, F. J. S., & Sánchez‐Vázquez, F. J. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1104327 · Cited by 44
“…to the extent that the working pattern decouples from the central master clock (SCN) to obey other synchronizing cues (Damiola et al., 2000; Hara et al., 2001; Schilber, 2009; Stokkan et al., 2001), and becomes tissue-specific for particular physiological processes (Betancor et al., 2014).”
Background
Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112
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Time-restricted feeding of rapidly digested starches causes stronger entrainment of the liver clock in PER2::LUCIFERASE knock-in mice
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Background
Clocks, Rhythms, Sex, and Hearts: How Disrupted Circadian Rhythms, Time-of-Day, and Sex Influence Cardiovascular Health
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Rapid damping of food-entrained circadian rhythm of clock gene expression in clock-defective peripheral tissues under fasting conditions
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Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline
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Authors: Hara, R., Wan, K., Wakamatsu, H., Aida, R., Moriya, T., Akiyama, M., & Shibata, S.
Affiliations: Waseda University (JP)
Corresponding author: Shibata, Shigenobu
ORCID: Shibata, Shigenobu
Venue: Genes to Cells
Publisher: Wiley
Published: 2001-03
Volume: 6
Issue: 3
Pages: 269-278
ISSN: 1356-9597 (ISSN-L)
1365-2443
DOI: 10.1046/j.1365-2443.2001.00419.x
OpenAlex: W1965036088
Cited by: 569
References: 28
Citations by year: 2026: 12 · 2025: 12 · 2024: 17 · 2023: 20 · 2022: 27 · 2021: 24 · 2020: 24 · 2019: 18 · 2018: 23 · 2017: 36 · 2016: 20 · 2015: 29 · 2014: 26 · 2013: 21 · 2012: 29
FWCI: 5.94
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2685 d)
Locations: Genes to Cells (publishedVersion)
PubMed (publishedVersion)
Funders: Ministerul Cercetării, Inovării şi Digitalizării
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: feed restriction, circadian entrainment, liver clock, suprachiasmatic nucleus, clock genes, Per1, Per2, DBP, SCN lesions, light-dark cycle, constant darkness
MeSH terms: Animals, Biological Clocks, Feeding Methods, Gene Expression Regulation, Liver, Male, Nuclear Proteins, Suprachiasmatic Nucleus, Transcription Factors, Cell Cycle Proteins, Mice, Period Circadian Proteins

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Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus

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