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Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus
Abstract
BACKGROUND: There are two main stimuli that entrain the circadian rhythm, the light-dark cycle (LD) and restricted feeding (RF). Light-induced entrainment requires induction of the Per1 and Per2 genes in the suprachiasmatic nucleus (SCN), the locus of a main oscillator. In this experiment, we determined whether RF resets the expression of circadian clock genes in the mouse liver with or without participation of the SCN. RESULTS: Mice were allowed access to food for 4 h during the daytime (7 h advance of feeding time) under LD or constant darkness (DD). The peaks of mPer1, mPer2, D-site-binding protein (Dbp) and cholesterol 7alpha-hydroxylase (Cyp7A) mRNA in the liver were advanced 6-12 h after 6 days of RF, whereas those in SCN were unaffected. The advance of mPer expression in the liver by RF was still observed in SCN-lesioned mice. A 7 h advance in the LD cycle advanced the peaks of clock gene expression in both the liver and SCN, whereas, a shift in the LD did not move the phase of the liver clock when the shift was carried out under a fixed RF schedule during the night-time. CONCLUSIONS: These results suggest that restricted feeding strongly entrained the expression of circadian clock genes in the liver without the participation of an SCN clock function.
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“In nocturnal rodents, feeding during the daytime hours for a week completely altered the phase of the circadian expression of clock and clock-controlled genes in the peripheral tissues [261,262].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [261]
In the citing paper
“Indeed, it was shown that rhythmic feeding is both necessary and sufficient to drive the circadian expression of liver genes [7,8]”
From Circadian control of glucose metabolism (2014) · cites this paper as [7]
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“…advances of the circadian rhythms of gene expression in the peripheral tissues and some brain structures, uncoupling them from the SCN whose entrainment to the light remains intact (Damiola et al., 2000; Stokkan et al., 2001; Hara et al., 2001; Wakamatsu et al., 2001; Cassone and Stephan, 2002).”
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Metadata
- Authors
- Hara, R., Wan, K., Wakamatsu, H., Aida, R., Moriya, T., Akiyama, M., & Shibata, S.
- Affiliations
- Waseda University (JP)
- Corresponding author
- Shibata, Shigenobu
- ORCID
- Shibata, Shigenobu
- Venue
- Genes to Cells
- Publisher
- Wiley
- Published
- 2001-03
- Volume
- 6
- Issue
- 3
- Pages
- 269-278
- ISSN
- 1356-9597 (ISSN-L)
- 1365-2443
- OpenAlex
- W1965036088
- Cited by
- 569
- References
- 28
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 17 · 2023: 20 · 2022: 27 · 2021: 24 · 2020: 24 · 2019: 18 · 2018: 23 · 2017: 36 · 2016: 20 · 2015: 29 · 2014: 26 · 2013: 21 · 2012: 29
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genes to Cells (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerul Cercetării, Inovării şi Digitalizării
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- feed restriction, circadian entrainment, liver clock, suprachiasmatic nucleus, clock genes, Per1, Per2, DBP, SCN lesions, light-dark cycle, constant darkness
- MeSH terms
- Animals, Biological Clocks, Feeding Methods, Gene Expression Regulation, Liver, Male, Nuclear Proteins, Suprachiasmatic Nucleus, Transcription Factors, Cell Cycle Proteins, Mice, Period Circadian Proteins
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