The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Restricted feeding entrains liver clock without participation of the suprachiasmatic nucleus
Abstract
BACKGROUND: There are two main stimuli that entrain the circadian rhythm, the light-dark cycle (LD) and restricted feeding (RF). Light-induced entrainment requires induction of the Per1 and Per2 genes in the suprachiasmatic nucleus (SCN), the locus of a main oscillator. In this experiment, we determined whether RF resets the expression of circadian clock genes in the mouse liver with or without participation of the SCN. RESULTS: Mice were allowed access to food for 4 h during the daytime (7 h advance of feeding time) under LD or constant darkness (DD). The peaks of mPer1, mPer2, D-site-binding protein (Dbp) and cholesterol 7alpha-hydroxylase (Cyp7A) mRNA in the liver were advanced 6-12 h after 6 days of RF, whereas those in SCN were unaffected. The advance of mPer expression in the liver by RF was still observed in SCN-lesioned mice. A 7 h advance in the LD cycle advanced the peaks of clock gene expression in both the liver and SCN, whereas, a shift in the LD did not move the phase of the liver clock when the shift was carried out under a fixed RF schedule during the night-time. CONCLUSIONS: These results suggest that restricted feeding strongly entrained the expression of circadian clock genes in the liver without the participation of an SCN clock function.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In nocturnal rodents, feeding during the daytime hours for a week completely altered the phase of the circadian expression of clock and clock-controlled genes in the peripheral tissues [261,262].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [261]
In the citing paper
“Indeed, it was shown that rhythmic feeding is both necessary and sufficient to drive the circadian expression of liver genes [7,8]”
From Circadian control of glucose metabolism (2014) · cites this paper as [7]
Citations
Cites
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Resetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907
Zylka, M. J., Shearman, L. P., Weaver, D. R., & Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80492-4 · Cited by 865
Circadian food-anticipatory activity: Formal models and physiological mechanisms
Mistlberger, R. E. (1994) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)90023-x · Cited by 857
Mueller, C. R., Maire, P., & Schibler, U. (1990) · Cell · doi:10.1016/0092-8674(90)90808-r · Cited by 384
Lopez‐Molina, L., Conquet, F., Dubois‐Dauphin, M., & Schibler, U. (1997) · The EMBO Journal · doi:10.1093/emboj/16.22.6762 · Cited by 310
Sakamoto, K., Nagase, T., Fukui, H., Horikawa, K., Okada, T., Tanaka, H., Sato, K. Z., Miyake, Y., Ohara, O., Kako, K., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27039 · Cited by 300
Lavery, D. J., & Schibler, U. (1993) · Genes & Development · doi:10.1101/gad.7.10.1871 · Cited by 300
Role of DBP in the Circadian Oscillatory Mechanism
Yamaguchi, S., Mitsui, S., Yan, L., Yagita, K., Miyake, S., & Okamura, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4773-4781.2000 · Cited by 252
Cited by
Sorted by citations
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265
“In SCN-lesioned mice, food entrainment organizes rhythms throughout the periphery, and stable phase relationships are observed among tissues (Hara et al. 2001, Pezuk et al. 2010).”
BackgroundRegulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms
Chiang, J. Y. L. (2003) · Journal of Hepatology · doi:10.1016/j.jhep.2003.11.006 · Cited by 559
The “other” circadian system: food as a Zeitgeber
Stephan, F. K. (2002) · Journal of Biological Rhythms · doi:10.1177/074873002129002591 · Cited by 672
“corticosterone and core temperature persist after SCN lesions, it is not surprising that gene expression in the liver becomes entrained to mealtime in mice with SCN lesions (Hara et al., 2001).”
BackgroundPeripheral Circadian Oscillators in Mammals: Time and Food
Schibler, U., Ripperger, J. A., & Brown, S. A. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403018003007 · Cited by 537
“As already mentioned, long-term circadian gene expression in peripheral tissues depends on a functional SCN pacemaker because no robustly cycling transcripts could be detected in SCN-lesioned mice (Hara et al., 2001).”
BackgroundInfluentialMetabolism and Circadian Rhythms—Implications for Obesity
Froy, O. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0014 · Cited by 505
“These findings suggest that synchronization of peripheral oscillators during CR could be achieved directly due to the temporal eating, as has been reported for RF (189, 192, 193), or by synchronizing the SCN (218–220), which in turn sends humoral or neuronal signals to entrain the peripheral tissues (38, 222).”
BackgroundGlucocorticoids and the circadian clock
Dickmeis, T. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0415 · Cited by 494
“Clock gene expression in the SCN remains linked with the light phase, while the phase of peripheral pacemakers adapts to the feeding regime, leading to phase shifts of up to 12 h (Damiola et al. 2000, Hara et al. 2001, Stokkan et al. 2001).”
BackgroundGooley, J. J., Schomer, A., & Saper, C. B. (2006) · Nature Neuroscience · doi:10.1038/nn1651 · Cited by 453
Biological Clocks and Shift Work: Circadian Dysregulation and Potential Long-term Effects
Haus, E. L., & Smolensky, M. H. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9015-4 · Cited by 399
Timing of food intake and obesity: a novel association
Garaulet, M., & Gómez-Abellán, P. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.01.001 · Cited by 362
Sleep and circadian rhythms: key components in the regulation of energy metabolism
Laposky, A. D., Bass, J., Kohsaka, A., & Turek, F. W. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.06.079 · Cited by 351
“Neurons in the SCN also contain hormones and neurotransmitters that are synthesized and released in a circadian manner, including transforming growth factor-a (TGF-a), prokineticin-2 (PK2), gamma-aminobutyric acid (GABA), and vasopressin [7].”
BackgroundInfluentialNeurobiology of food anticipatory circadian rhythms
Mistlberger, R. E. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.015 · Cited by 357
Interplay of Circadian Clocks and Metabolic Rhythms
Wijnen, H., & Young, M. W. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090603 · Cited by 341
Circadian control of glucose metabolism
Kalsbeek, A., la Fleur, S., & Fliers, E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.03.002 · Cited by 338
Hirota, T., Okano, T., Kokame, K., Shirotani-Ikejima, H., Miyata, T., & Fukada, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206233200 · Cited by 317
Regulation of Feeding and Metabolism by Neuronal and Peripheral Clocks in Drosophila
Xu, K., Zheng, X., & Sehgal, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.006 · Cited by 306
“In mammals, the central pacemaker is in the suprachiasmatic nuclei (SCN) of the hypothalamus (Aton and Herzog, 2005; Liu et al., 2007) and peripheral clocks are located in multiple organs including the liver (Shibata, 2004), heart (Young, 2006), pineal gland (Fukada and Okano, 2002), and adipose tissue (Zvonic et al.,…”
BackgroundInfluentialAdrenergic regulation of clock gene expression in mouse liver
Terazono, H., Mutoh, T., Yamaguchi, S., Kobayashi, M., Akiyama, M., Udo, R., Ohdo, S., Okamura, H., & Shibata, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0936797100 · Cited by 293
The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker
Mieda, M., Williams, S. C., Richardson, J. A., Tanaka, K., & Yanagisawa, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604189103 · Cited by 290
The relationship between nutrition and circadian rhythms in mammals
Froy, O. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.03.001 · Cited by 295
“, are phaseshifted by RF to the time of food availability [12,54,57,95].”
BackgroundInfluentialRandomized controlled trial for time-restricted eating in healthy volunteers without obesity
Xie, Z., Sun, Y., Ye, Y., Hu, D., Zhang, H., He, Z., Zhao, H., Yang, H., & Mao, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-28662-5 · Cited by 276
Hoogerwerf, W. A., Hellmich, H. L., Cornélissen, G., Franz Halberg, A., Shahinian, V. B., Bostwick, J., Savidge, T., & Cassone, V. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.009 · Cited by 268
“Several studies have demonstrated that changes in feeding schedule can shift the acrophase of hepatic clock genes 19–21 but not pulmonary clock genes.”
Resetting Mechanism of Central and Peripheral Circadian Clocks in Mammals
Hirota, T., & Fukada, Y. (2004) · ZOOLOGICAL SCIENCE · doi:10.2108/zsj.21.359 · Cited by 264
“However, an abrupt change in the feeding time schedule (from night to day) for several days gradually uncouples the periphery from the SCN by shifting the phase of the peripheral clocks but not the central clock in mice (Damiola et al., 2000; Hara et al., 2001; Stokkan et al., 2001).”
BackgroundCircadian clocks: setting time by food
Mendoza, J. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01510.x · Cited by 257
Feeding Rhythms and the Circadian Regulation of Metabolism
Pickel, L., & Sung, H. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00039 · Cited by 282
“Furthermore, phase advancing the light–dark cycle does not alter the phase of the liver clock if accompanied by a fixed restricted feeding schedule, and restricted feeding entrains the liver even in SCNlesioned mice (37).”
BackgroundLamont, E. W., Robinson, B., Stewart, J., & Amir, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500901102 · Cited by 256
The Circadian Clock in Arabidopsis Roots Is a Simplified Slave Version of the Clock in Shoots
James, A. B., Monreal, J. A., Nimmo, G. A., Kelly, C. L., Herzyk, P., Jenkins, G. I., & Nimmo, H. G. (2008) · Science · doi:10.1126/science.1161403 · Cited by 261
Mammalian circadian clock and metabolism – the epigenetic link
Bellet, M. M., & Sassone‐Corsi, P. (2010) · Journal of Cell Science · doi:10.1242/jcs.051649 · Cited by 240
“mice that have specific lesions of the SCN when they are exposed to either light-dark cycles or to constant darkness (Hara et al., 2001; Stephan, 2002; Stokkan et al., 2001).”
BackgroundCircadian rhythms of liver physiology and disease: experimental and clinical evidence
Tahara, Y., & Shibata, S. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.8 · Cited by 238
Clock is important for food and circadian regulation of macronutrient absorption in mice
Pan, X., & Hussain, M. M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900085-jlr200 · Cited by 226
New Insights Into the Circadian Rhythm and Its Related Diseases
Xie, Y., Tang, Q., Chen, G., Xie, M., Yu, S., Zhao, J., & Chen, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00682 · Cited by 250
Circadian eating and sleeping patterns in the night eating syndrome
O'Reardon, J. P., Ringel, B. L., Dinges, D. F., Allison, K. C., Rogers, N. L., Martino, N. S., & Stunkard, A. J. (2004) · Obesity Research · doi:10.1038/oby.2004.222 · Cited by 223
Genetic analysis of the circadian system in Drosophila melanogaster and mammals
Stanewsky, R. (2002) · Journal of Neurobiology · doi:10.1002/neu.10164 · Cited by 220
“Contrary to flies, Clk is expressed constitutively in mice (at least in the SCN and fibroblasts), while Bmal1 shows rhythmic expression, both on the RNA and protein level in all tissues examined, including the SCN (Shearman et al., 2000b; Tamaru et al., 2000; Lee et al., 2001; Yagita et al., 2001).”
BackgroundInfluentialAlmoosawi, S., Vingeliene, S., Karagounis, L. G., & Pot, G. K. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000306 · Cited by 218
Circadian Rhythms, the Molecular Clock, and Skeletal Muscle
Harfmann, B. D., Schroder, E. A., & Esser, K. A. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730414561638 · Cited by 211
“In liver, this was shown to be independent of SCN input, since timerestricted feeding prevented the shift of the clock genes when the mice were exposed to a 7-h light:dark cycle advance (Hara et al., 2001).”
Mendoza, J., Graff, C., Dardente, H., Pévet, P., & Challet, É. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4397-04.2005 · Cited by 215
“Although the ratio of daytime/nighttime intake is then less drastic than that in daytime restricted feeding (that is, a food access strictly restricted to daytime) as used by others (Damiola et al., 2000; Hara et al., 2001; Stokkan et al., 2001; Wakamatsu et al., 2001), neither normocaloric feeding nor daytime restric…”
BackgroundLack of Food Anticipation in Per2 Mutant Mice
Feillet, C. A., Ripperger, J. A., Magnone, M. C., Dulloo, A. G., Albrecht, U., & Challet, É. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.053 · Cited by 208
“In WT mice, such advances are usually absent under temporal food restriction [8, 9], although they can be observed under hypocaloric conditions [13, 14] (but see also [15]).”
BackgroundEffects of light and food schedules on liver and tumor molecular clocks in mice
Filipski, E., Innominato, P. F., Wu, M., Li, X.-M., Iacobelli, S., Xian, L.-J., & Levi, F. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji083 · Cited by 200
Tahara, Y., & Shibata, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.049 · Cited by 198
“…17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 6 hydroxylase (Cyp7A) mRNA expression rhythms in the liver underwent phase shifting and entrainment with daytime feedings in mice (Hara et al., 2001).”
Nutrients, Clock Genes, and Chrononutrition
Oike, H., Oishi, K., & Kobori, M. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0082-6 · Cited by 198
The mammalian circadian clock and its entrainment by stress and exercise
Tahara, Y., Aoyama, S., & Shibata, S. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-016-0450-7 · Cited by 198
“Food also has the potential to entrain peripheral clocks but only has small effects on the master clock, since the light signal is the most important stimulus in the SCN [12, 13].”
BackgroundSelf-citationPapakonstantinou, E., Oikonomou, C., Nychas, G., & Dimitriadis, G. D. (2022) · Nutrients · doi:10.3390/nu14040823 · Cited by 199
Cailotto, C., La Fleur, S. E., Van Heijningen, C., Wortel, J., Kalsbeek, A., Feenstra, M., Pévet, P., & Buijs, R. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04439.x · Cited by 191
“001) in accordance with data previously described in mouse and rat (Zylka et al., 1998; Damiola et al., 2000; Hara et al., 2001; Miki et al., 2003; Yamamoto et al., 2004).”
ResultInfluentialIn Vivo Monitoring of Peripheral Circadian Clocks in the Mouse
Tahara, Y., Kuroda, H., Saito, K., Nakajima, Y., Kubo, Y., Ohnishi, N., Seo, Y., Otsuka, M., Fuse, Y., Ohura, Y., et al. (2012) · Current Biology · doi:10.1016/j.cub.2012.04.009 · Cited by 191
When Clocks Go Bad: Neurobehavioural Consequences of Disrupted Circadian Timing
Barnard, A. R., & Nolan, P. M. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000040 · Cited by 191
Landry, G. J., Simon, M. M., Webb, I. C., & Mistlberger, R. E. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00874.2005 · Cited by 179
“For peripheral organs, feeding time may be the dominant entraining stimulus, and the SCN may regulate the phase of these peripheral oscillators indirectly, by driving the daily rhythm of food intake when food is available ad libitum (20, 31, 57, 63).”
BackgroundCircadian metabolism in the light of evolution
Gerhart-Hines, Z., & Lazar, M. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1007 · Cited by 178
Yasumoto, Y., Hashimoto, C., Nakao, R., Yamazaki, H., Hiroyama, H., Nemoto, T., Yamamoto, S., Sakurai, M., Oike, H., Wada, N., et al. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.003 · Cited by 168
“The central clock in the SCN is dispensable for entraining peripheral clocks to feeding cycles [5] and core components of the molecular clock such as Clock [6] or Per genes [7] are not essential for entraining peripheral clocks to feeding cycles.”
BackgroundHepatic Nervous System and Neurobiology of the Liver
Jensen, K. J., Alpini, G. D., & Glaser, S. S. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120018 · Cited by 168
Clock Genes and Clock-Controlled Genes in the Regulation of Metabolic Rhythms
Mazzoccoli, G., Pazienza, V., & Vinciguerra, M. (2012) · Chronobiology International · doi:10.3109/07420528.2012.658127 · Cited by 173
“Restricted feeding resets the phase of clock gene expression in peripheral tissues, but not in the SCN (Damiola et al., 2000; Hara et al., 2001), and in peripheral tissues clock gene entrainment by feeding shows different degree and rapidity of response to nutritional cues among the different…”
BackgroundNakamura, T. J., Moriya, T., Inoue, S., Shimazoe, T., Watanabe, S., Ebihara, S., & Shinohara, K. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20677 · Cited by 165
“…nucleus (SCN) of the anterior hypothalamus, which is the locus of the central clock regulating daily behavioral rhythm (Inouye and Shibata, 1994), brain regions outside the SCN, and various peripheral tissues such as liver, kidney, and uterus (Damiola et al., 2000; Hara et al., 2001).”
BackgroundInfluentialCircadian adaptations to meal timing: neuroendocrine mechanisms
Patton, D. F., & Mistlberger, R. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00185 · Cited by 175
“If a daily LD cycle is present, the SCN itself is not shifted by daytime feeding schedules (Damiola et al., 2000; Hara et al., 2001a; Stokkan et al., 2001).”
BackgroundCastellanos, A., Mendoza, J., & Escobar, C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.064 · Cited by 170
Synchronization of the Molecular Clockwork by Light- and Food-Related Cues in Mammals
Challet, É., Caldelas, I., Graff, C., & Pévet, P. (2003) · Biological Chemistry · doi:10.1515/bc.2003.079 · Cited by 161
“, daily food access limited to daytime) does not modify the temporal organization of the molecular loops within the SCN (Damiola et al., 2000; Hara et al., 2001; Stokkan et al., 2001; Wakamatsu et al., 2001).”
InfluentialInternal desynchronization in a model of night-work by forced activity in rats
Salgado-Delgado, R., Ángeles-Castellanos, M., Buijs, M. R., & Escobar, C. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.066 · Cited by 157
A role of the circadian system and circadian proteins in aging
KONDRATOV, R. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.02.003 · Cited by 149
Insight Into the Circadian Clock Within Rat Colonic Epithelial Cells
Sládek, M., Rybová, M., Jindráková, Z., Zemanová, Z., Polidarová, L., Mrnka, L., O'Neill, J. S., Pácha, J., & Sumová, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.053 · Cited by 159
Clock Genes in Cell Clocks: Roles, Actions, and Mysteries
Okamura, H. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730404269169 · Cited by 157
“This feeding-related entrainment is strong and is observed in SCN-lesioned animals, which indicates that it is independent of the central clock (Hara et al., 2001).”
BackgroundCircadian Rhythms, Aging, and Life Span in Mammals
Froy, O. (2011) · Physiology · doi:10.1152/physiol.00012.2011 · Cited by 156
The role of the circadian clock system in physiology
Pilorz, V., Helfrich‐Förster, C., & Oster, H. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2103-y · Cited by 164
“The locus of FEO in the body as well as the underlying mechanism, however, is still poorly understood and subject of ongoing investigations.”
InfluentialCircadian control of root elongation and C partitioning in Arabidopsis thaliana
Yazdanbakhsh, N., Ronan Sulpice, A., Graf, A., Stitt, M., & Fisahn, J. (2011) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2011.02286.x · Cited by 154
Gradients in the circadian expression of Per1 and Per2 genes in the rat suprachiasmatic nucleus
Yan, L., & Okamura, H. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01955.x · Cited by 146
“…has been accumulating that suggests the peripheral tissues also have the SCN-independent circadian oscillating under some special conditions, such as glucocorticoid administration (Balsalobre et al., 1998) or restricted feeding (Damiola et al., 2000; Yamazaki et al., 2000; Hara et al., 2001).”
BackgroundJakubowicz, D., Wainstein, J., Ahrén, B., Bar-Dayan, Y., Landau, Z., Rabinovitz, H. R., & Froy, O. (2015) · Diabetologia · doi:10.1007/s00125-015-3524-9 · Cited by 139
Circadian Dysregulation Disrupts Bile Acid Homeostasis
Ma, K., Xiao, R., Tseng, H.-T., Shan, L., Fu, L., & Moore, D. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006843 · Cited by 146
“As shown in Figure 3A, the expression patterns of Bmal1, Per2, Rev-erba and DBP were all effectively reversed by RF, as expected [2,32].”
InfluentialAKT and TOR Signaling Set the Pace of the Circadian Pacemaker
Zheng, X., & Sehgal, A. (2010) · Current Biology · doi:10.1016/j.cub.2010.05.027 · Cited by 147
Circadian disruption accelerates liver carcinogenesis in mice
Filipski, E., Subramanian, P., Carrière, J., Guettier, C., Barbason, H., & Lévi, F. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2009.10.002 · Cited by 146
Circadian Rhythms in Diet-Induced Obesity
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_2 · Cited by 149
“While the SCN directly entrains feeding behavior to the light-dark cycle, daytime feeding shifts the timing of PER expression in the liver (Damiola et al. 2000; Hara et al. 2001).”
BackgroundDisruption of Circadian Coordination and Malignant Growth
Filipski, E., Li, X. M., & Lévi, F. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9007-4 · Cited by 141
Mühlbauer, E., Gross, E. C., Labucay, K., Wolgast, S., & Peschke, E. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.01.029 · Cited by 148
“A connection between restricted feeding and organ-internal functions was established by Damiola et al. (2000), Hara et al. (2001) and Stokkan et al. (2001) to be governed by internal clocks in liver, lung and pancreas, as well as by the clocks' interactions with the major oscillator of the nucleus…”
BackgroundDisruption of Circadian Rhythms: A Crucial Factor in the Etiology of Depression
Salgado‐Delgado, R., Osorio, A. T., Saderi, N., & Escobar, C. (2011) · Depression Research and Treatment · doi:10.1155/2011/839743 · Cited by 148
“Although they do not override the light/dark cycle for the adjustment of the SCN, nonphotic stimuli, especially food, contribute as potent synchronizers of cells and organs in the periphery, driving them out of phase from the signals transmitted by the SCN, thus resulting in internal desynchrony [50–52] (Figure 4).”
BackgroundCellular oscillators: rhythmic gene expression and metabolism
Schibler, U., & Naef, F. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.01.007 · Cited by 139
Effect of feeding regimens on circadian rhythms: Implications for agingand longevity
Froy, O., & Miskin, R. (2010) · Aging · doi:10.18632/aging.100116 · Cited by 143
“In turn, some of these functions can feedback to the biological clock in the periphery [143, 153] and the SCN [191, 192] and help sustain the rhythms.”
BackgroundInfluentialJames, F. O., Cermakian, N., & Boivin, D. B. (2007) · Sleep · doi:10.1093/sleep/30.11.1427 · Cited by 135
Husse, J., Leliavski, A., Tsang, A. H., Oster, H., & Eichele, G. (2014) · The FASEB Journal · doi:10.1096/fj.14-256594 · Cited by 133
Verwey, M., Khoja, Z., Stewart, J., & Amir, S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.044 · Cited by 132
“, 2005; Mendoza, 2007), suggesting that expression of clock genes in the brain and periphery is not only sensitive to signals from the SCN but also responds to changes in nutritional and/or motivational state independently of the SCN (Hara et al., 2001).”
BackgroundResultInfluentialThe regulation of central and peripheral circadian clocks in humans
Cermakian, N., & Boivin, D. B. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00660.x · Cited by 129
Sakai, R., Hashimoto, Y., Ushigome, E., Miki, A., Okamura, T., Matsugasumi, M., Fukuda, T., Majima, S., Matsumoto, S., Senmaru, T., et al. (2018) · Endocrine Journal · doi:10.1507/endocrj.ej17-0414 · Cited by 132
“Food intake modulates the circadian rhythms, especially in liver and intestine [37, 38] and misalignment of circadian rhythm leads to insulin resistance and diabetes [39, 40].”
BackgroundThe Biological Clock: The Bodyguard of Temporal Homeostasis
Perreau‐Lenz, S., Pévet, P., Buijs, R. M., & Kalsbeek, A. (2004) · Chronobiology International · doi:10.1081/cbi-120027984 · Cited by 139
“Subsequently, the same clock genes were also found to be expressed rhythmically in other structures, both in the central nervous system (Abe et al., 2002; Yamazaki et al., 2000) and in the periphery (Damiola et al., 2000; Hara et al., 2001; Yamazaki et al., 2000).”
BackgroundEntrainment of the mouse circadian clock by sub-acute physical and psychological stress
Tahara, Y., Shiraishi, T., Kikuchi, Y., Haraguchi, A., Kuriki, D., Sasaki, H., Motohashi, H., Sakai, T., & Shibata, S. (2015) · Scientific Reports · doi:10.1038/srep11417 · Cited by 134
Wible, R. S., Ramanathan, C., Sutter, T. R., Olesen, K. M., Kensler, T. W., Liu, A. C., & Sutter, T. R. (2018) · eLife · doi:10.7554/elife.31656 · Cited by 126
“A predominant entraining signal in peripheral tissues is diurnal metabolic cycles (Hara et al., 2001).”
BackgroundMendoza, J., Castellanos, A., & Escobar, C. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.064 · Cited by 130
Food-entrained circadian rhythms are sustained in arrhythmic Clk/Clk mutant mice
Pitts, S., Perone, E. A., & Silver, R. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00023.2003 · Cited by 126
“the timing of Per expression in the liver in both intact and SCN-lesioned mice (7, 12).”
BackgroundCircadian disruption in experimental cancer processes
Filipski, E., & Lévi, F. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409352085 · Cited by 125
“To check this hypothesis we used meal timing, which is a strong ZT and was reported to enhance circadian coordination in the liver and in other peripheral organs30,31 even in the absence of functional SCN.32 We inoculated GOS or P03 to mice fed ad libitum and to mice fed only during 4 hours in the light span, from ZT…”
MethodTahara, Y., Otsuka, M., Fuse, Y., Hirao, A., & Shibata, S. (2011) · Journal of Biological Rhythms · doi:10.1177/0748730411405958 · Cited by 125
“…cortex can be entrained by restricted feeding stimuli within 2 days, which is the period required before FAA can develop (Damiola et al., 2000; Hara et al., 2001; Wakamatsu et al., 2001; Wu et al., 2004), suggesting a dissociation between the mechanisms of behavioral FAA rhythms and…”
BackgroundInfluentialChronobesity: role of the circadian system in the obesity epidemic
Laermans, J., & Depoortere, I. (2015) · Obesity Reviews · doi:10.1111/obr.12351 · Cited by 129
“So far, brain lesion studies in mice have indicated that loss of several different single brain regions does not completely eliminate FAA (72,73,78,79), implying that rhythmicity is safeguarded by a multitude of FEOs in a number of anatomical locations.”
BackgroundInfluentialMoriya, T., Aida, R., Kudo, T., Akiyama, M., Doi, M., Hayasaka, N., Nakahata, N., Mistlberger, R. E., Okamura, H., & Shibata, S. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06697.x · Cited by 124
“Notably, food-anticipatory rhythms persist following complete SCN ablation (Stephan et al., 1979; Hara et al., 2001), indicating control by entrainable oscillators located elsewhere (Mistlberger, 1994; Stephan, 2002).”
BackgroundInfluentialMammalian circadian systems: Organization and modern life challenges
Finger, A., & Kramer, A. (2021) · Acta Physiologica · doi:10.1111/apha.13548 · Cited by 117
Iijima, M., Nikaido, T., Akiyama, M., Moriya, T., & Shibata, S. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02140.x · Cited by 122
“Restricted feeding rapidly entrains the Per gene expression rhythm in the liver (Damiola et al., 2000; Hara et al., 2001; Stokkan et al., 2001) as well as clocks in the cerebral cortex and hippocampus, but not the SCN (Wakamatsu et al., 2001).”
BackgroundSelf-citationGeiger, S. S., Fagundes, C. T., & Siegel, R. M. (2015) · Immunology · doi:10.1111/imm.12525 · Cited by 122
The Cerebellum Harbors a Circadian Oscillator Involved in Food Anticipation
Mendoza, J., Pévet, P., Felder‐Schmittbuhl, M., Bailly, Y. J. R., & Challet, É. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5855-09.2010 · Cited by 122
“Scheduled restricted feeding is a dominant synchronizer for circadian oscillations in peripheral organs, such as the liver (Damiola et al., 2000; Hara et al., 2001; Stokkan et al., 2001).”
BackgroundInteractions between metabolism and circadian clocks: reciprocal disturbances
Delezie, J., & Challet, É. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06246.x · Cited by 124
Cancer Inhibition through Circadian Reprogramming of Tumor Transcriptome with Meal Timing
Li, X., Delaunay, F., Dulong, S., Claustrat, B., Zampera, S., Fujii, Y., Teboul, M., Beau, J., & Lévi, F. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4235 · Cited by 123
Charlot, A., Hutt, F., Sabatier, E., & Zoll, J. (2021) · Nutrients · doi:10.3390/nu13051405 · Cited by 125
Mindikoglu, A. L., Abdulsada, M. M., Jain, A., Choi, J. M., Jalal, P. K., Devaraj, S., Mezzari, M. P., Petrosino, J. F., Opekun, A. R., & Jung, S. Y. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103645 · Cited by 121
“The second mechanism to reset the circadian clock works in response to mealtime during rhythmic, consecutive, time-restricted feeding-fasting cycles.[5, 7, 10] Rhythmic consecutive time-restricted feeding-fasting cycles have shown to release peripheral clocks, including the hepatic clock, from the control of the maste…”
BackgroundInfluentialPeripheral Circadian Clocks in the Vasculature
Reilly, D. F., Westgate, E. J., & FitzGerald, G. A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.144923 · Cited by 117
Hypothalamic clocks and rhythms in feeding behaviour
Bechtold, D. A., & Loudon, A. S. I. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.007 · Cited by 121
Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition
Tahara, Y., & Shibata, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.026 · Cited by 120
“In contrast to the light-dependent central clock, the peripheral clocks can be entrained by food or temperature, even if it is in normal light–dark conditions [14-16].”
BackgroundSun, L., Wang, Y., Song, Y., Cheng, X., Xia, S., Rahman, M. R. T., Shi, Y., & Le, G. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.072 · Cited by 111
The hypothalamic clock and its control of glucose homeostasis
Kalsbeek, A., Yi, C., la Fleur, S. E., & Fliers, E. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.02.005 · Cited by 112
“Since it has been shown that a change in feeding pattern has pronounced effects on clock gene expression in the liver (Damiola et al., 2000; Hara et al., 2001; Stokkan et al., 2001), we first investigated whether our 6-meals-a-day feeding schedule affected the normal daily rhythm of clock gene expression in the liver.”
BackgroundOishi, K., Kasamatsu, M., & Ishida, N. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.055 · Cited by 107
Role of clock genes in gastrointestinal motility
Hoogerwerf, W. A. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00147.2010 · Cited by 107
Metadata
- Authors
- Hara, R., Wan, K., Wakamatsu, H., Aida, R., Moriya, T., Akiyama, M., & Shibata, S.
- Affiliations
- Waseda University (JP)
- Corresponding author
- Shibata, Shigenobu
- ORCID
- Shibata, Shigenobu
- Venue
- Genes to Cells
- Publisher
- Wiley
- Published
- 2001-03
- Volume
- 6
- Issue
- 3
- Pages
- 269-278
- ISSN
- 1356-9597 (ISSN-L)
- 1365-2443
- OpenAlex
- W1965036088
- Cited by
- 569
- References
- 28
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 17 · 2023: 20 · 2022: 27 · 2021: 24 · 2020: 24 · 2019: 18 · 2018: 23 · 2017: 36 · 2016: 20 · 2015: 29 · 2014: 26 · 2013: 21 · 2012: 29
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genes to Cells (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerul Cercetării, Inovării şi Digitalizării
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- feed restriction, circadian entrainment, liver clock, suprachiasmatic nucleus, clock genes, Per1, Per2, DBP, SCN lesions, light-dark cycle, constant darkness
- MeSH terms
- Animals, Biological Clocks, Feeding Methods, Gene Expression Regulation, Liver, Male, Nuclear Proteins, Suprachiasmatic Nucleus, Transcription Factors, Cell Cycle Proteins, Mice, Period Circadian Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
