The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Epigenetic marks by DNA methylation specific to stem, germ and somatic cells in mice
Abstract
Background: DNA methylation is involved in many gene functions such as gene‐silencing, X‐inactivation, imprinting and stability of the gene. We recently found that some CpG islands had a tissue‐dependent and differentially methylated region (T‐DMR) in normal tissues, raising the possibility that there may be more CpG islands capable of differential methylation. Results: We investigated the genome‐wide DNA methylation pattern of CpG islands by restriction landmark genomic scanning (RLGS) in mouse stem cells (ES, EG and trophoblast stem) before and after differentiation, and sperm as well as somatic tissues. A total of 247 spots out of 1500 (16%) showed differences in the appearance of their RLGS profiles, indicating that CpG islands having T‐DMR were numerous and widespread. The methylation pattern was specific, and varied in a precise manner according to cell lineage, tissue type and during cell differentiation. Conclusions: Genomic loci with altered methylation status seem to be more common than has hitherto been realized. The formation of DNA methylation patterns at CpG islands is one of the epigenetic events which underlies the production of various cell types in the body. These findings should have implications for the use of embryonic stem cells and cells derived from them therapeutically, and also for the cloning of animals by the transfer of somatic cell nuclei.
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Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Epigenetic Reprogramming in Mammalian Development
Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078
Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells
Lanza, R. P., Cibelli, J. B., Blackwell, C., Cristofalo, V. J., Francis, M. K., Baerlocher, G. M., Mak, J., Schertzer, M., Chavez, E. A., Sawyer, N., et al. (2000) · Science · doi:10.1126/science.288.5466.665 · Cited by 466
Strain difference in establishment of mouse embryonic stem (ES) cell lines
Kawase, E., Suemori, H., Takahashi, N., Okazaki, K., Hashimoto, K., & Nakatsuji, N. (1994) · The International Journal of Developmental Biology · doi:10.1387/ijdb.7981049 · Cited by 203
Cited by
Illingworth, R. S., & Bird, A. P. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.04.012 · Cited by 887
Trefoil factors: initiators of mucosal healing
Taupin, D., & Podolsky, D. K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1203 · Cited by 629
Comparative isoschizomer profiling of cytosine methylation: The HELP assay
Khulan, B., Thompson, R. F., Ye, K., Fazzari, M. J., Suzuki, M., Stasiek, E., Figueroa, M. E., Glass, J. L., Chen, Q., Montagna, C., et al. (2006) · Genome Research · doi:10.1101/gr.5273806 · Cited by 396
Expression of various genes is controlled by DNA methylation during mammalian development
Ehrlich, M. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10464 · Cited by 290
Ohgane, J., Yagi, S., & Shiota, K. (2008) · Placenta · doi:10.1016/j.placenta.2007.09.011 · Cited by 111
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Metadata
- Authors
- Shiota, K., Kogo, Y., Ohgane, J., Imamura, T., Urano, A., Nishino, K., Tanaka, S., & Hattori, N.
- Venue
- Genes to Cells
- Publisher
- Wiley
- Published
- 2002-09
- Volume
- 7
- Issue
- 9
- Pages
- 961-969
- ISSN
- 1356-9597 (ISSN-L)
- 1365-2443
- OpenAlex
- W2090357268
- Cited by
- 195
- References
- 5
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shiota, K., Kogo, Y., Ohgane, J., Imamura, T., Urano, A., Nishino, K., Tanaka, S., & Hattori, N. (2002). Epigenetic marks by DNA methylation specific to stem, germ and somatic cells in mice. Genes to Cells. https://doi.org/10.1046/j.1365-2443.2002.00574.x
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