A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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TOR, a Central Controller of Cell Growth

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

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Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

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Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

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THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?

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Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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Mammalian TOR: a homeostatic ATP sensor

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Suppression of Lung Tumorigenesis by Leucine Zipper/EF Hand–Containing Transmembrane-1

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Exploiting the mammalian target of rapamycin pathway in hematologic malignancies

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The ketone body β-hydroxybutyric acid influences agouti-related peptide expression via AMP-activated protein kinase in hypothalamic GT1-7 cells

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AMPK allostery: A therapeutic target for the management/treatment of diabetic nephropathy

Ayinde, K. S., Olaoba, O. T., Boyenle, I. D., Du, L., Lü, Q., Yin, X., & Adelusi, T. I. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118455 · Cited by 34

Dynamics of Elongation Factor 2 Kinase Regulation in Cortical Neurons in Response to Synaptic Activity

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Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy- d -glucose under hypoxia in lung cancer cell lines

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The Mammalian Target of Rapamycin Kinase and Tumor Growth Inhibition

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Neohesperidin Dihydrochalcone and Neohesperidin Dihydrochalcone-O-Glycoside Attenuate Subcutaneous Fat and Lipid Accumulation by Regulating PI3K/AKT/mTOR Pathway In Vivo and In Vitro

Kwon, M., Kim, Y., Lee, J., Manthey, J. A., Kim, Y., & Kim, Y. (2022) · Nutrients · doi:10.3390/nu14051087 · Cited by 35

Activation of AMP‐activated Protein Kinase and Phosphorylation of Glycogen Synthase Kinase3 β Mediate Ursolic Acid Induced Apoptosis in HepG2 Liver Cancer Cells

Son, H., Kwon, H. Y., Sohn, E. J., Lee, J., Woo, H.-J., Yun, M., Kim, S., & Kim, Y. (2013) · Phytotherapy Research · doi:10.1002/ptr.4925 · Cited by 34

Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): A double-edged sword?

Zeng, L., McDaniel, S. S., Rensing, N. R., & Wong, M. (2010) · Cell Cycle · doi:10.4161/cc.9.12.11866 · Cited by 34

Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.

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Glucocorticoids retard skeletal muscle development and myoblast protein synthesis through a mechanistic target of rapamycin (mTOR)-signaling pathway in broilers (Gallus gallus domesticus)

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Leucine alleviates dexamethasone-induced suppression of muscle protein synthesis via synergy involvement of mTOR and AMPK pathways

Wang, X. J., Yang, X. P., Wang, R. X., Jiao, H., Zhao, J. P., Song, Z., & Lin, H. (2016) · Bioscience Reports · doi:10.1042/bsr20160096 · Cited by 34

Chronic Hypoxia-Induced Autophagy Aggravates the Neuropathology of Alzheimer’s Disease through AMPK-mTOR Signaling in the APP Swe /PS1 dE9 Mouse Model

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Lack of Sprouty 1 and 2 enhances survival of effector CD8 + T cells and yields more protective memory cells

Shehata, H. M., Khan, S., Chen, E., Fields, P. E., Flavell, R. A., & Sanjabi, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808320115 · Cited by 31

Glucose-induced binding of the polypyrimidine tract-binding protein (PTB) to the 3′-untranslated region of the insulin mRNA (ins-PRS) is inhibited by rapamycin

Tillmar, L., & Welsh, N. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000026059.56089.e4 · Cited by 32

Is it time to test biguanide metformin in the treatment of melanoma?

Cerezo, M., Tomić, T., Ballotti, R., & Rocchi, S. (2014) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12267 · Cited by 32

Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell

Kakazu, E., Kondo, Y., Kogure, T., Ninomiya, M., Kimura, O. S., Ueno, Y., & Shimosegawa, T. (2013) · Scientific Reports · doi:10.1038/srep03459 · Cited by 30

Modulation of the activities of AMP‐activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2‐deoxyglucose

Jiang, W., Zhu, Z., & Thompson, H. J. (2008) · Molecular Carcinogenesis · doi:10.1002/mc.20425 · Cited by 32

Nectandrin B-mediated activation of the AMPK pathway prevents cellular senescence in human diploid fibroblasts by reducing intracellular ROS levels

Jang, H.-J., Yang, K. E., Oh, W. K., Lee, S.-I., Hwang, I.-H., Ban, K.-T., Yoo, H.-S., Choi, J.-S., Yeo, E.-J., & Jang, I.-S. (2019) · Aging · doi:10.18632/aging.102013 · Cited by 30

A novel protoapigenone analog RY10-4 induces breast cancer MCF-7 cell death through autophagy via the Akt/mTOR pathway

Zhang, X., Han, W., Liu, Z., Yuan, Q., Wei, A., Du, S., Yang, X. Z., & Ruan, J. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.04.011 · Cited by 30

Regulation of innate immune responses by rabies virus

Zhang, H., Huang, J., Song, Y., Liu, X., Qian, M., Huang, P., Li, Y., Zhao, L., & Wang, H. (2022) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12273 · Cited by 29

Therapeutic potential of mTOR inhibitors for targeting cancer stem cells

Francipane, M. G., & Lagasse, E. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12844 · Cited by 31

AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance-trained rats

Hurst, D., Taylor, E. B., Cline, T. D., Greenwood, L. J., Compton, C. L., Lamb, J. D., & Winder, W. W. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00155.2005 · Cited by 29

Targeted Metabolomics Reveals Abnormal Hepatic Energy Metabolism by Depletion of β-Carotene Oxygenase 2 in Mice

Wu, L., Guo, X., Lyu, Y., Clarke, S. L., Lucas, E. A., Smith, B. J., Hildebrand, D. A., Wang, W., Medeiros, D. M., Shen, X., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15222-x · Cited by 29

Role of SIRT-3, p-mTOR and HIF-1α in Hepatocellular Carcinoma Patients Affected by Metabolic Dysfunctions and in Chronic Treatment with Metformin

Matteis, S. D., Scarpi, E., Granato, A. M., Gentilucci, U. V., Barba, G. L., Foschi, F. G., Bandini, E., Ghetti, M., Marisi, G., Cravero, P., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061503 · Cited by 30

Molecular mechanisms of anticancer activities of polyphyllin VII

Ahmad, B., Rehman, S. U., Azizullah, A., Khan, M. F., Din, S. R. U., Ahmad, M., Ali, A., Tahir, N., Azam, N., Gamallat, Y., et al. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13818 · Cited by 29

Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis

Ahmad, B., Gamallat, Y., Khan, M. F., Din, S. R. U., Israr, M., Ahmad, M., Tahir, N., Azam, N., Rahman, K. U., Wang, X., et al. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s287354 · Cited by 30

mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol

González‐García, I., de Morentin, P. B. M., Estévez‐Salguero, Á., Contreras, C., Romero, A., Fernø, J., Nogueiras, R., Diéguez, C., Tena‐Sempere, M., Tovar, S. A., et al. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0190 · Cited by 26

AMP ‐activated protein kinase ( AMPK )–induced preconditioning in primary cortical neurons involves activation of MCL ‐1

Anilkumar, U., Weisová, P., Düßmann, H., Concannon, C. G., König, H., & Prehn, J. H. M. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12108 · Cited by 28

Regulatory effects of ghrelin on endoplasmic reticulum stress, oxidative stress, and autophagy: Therapeutic potential

Wang, H., Dou, S., Zhu, J., Shao, Z., Wang, C., & Cheng, B. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102112 · Cited by 27

The importance of RNA binding proteins in preproinsulin mRNA stability

Fred, R. G., & Welsh, N. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.06.007 · Cited by 27

Bovine ephemeral fever virus triggers autophagy enhancing virus replication via upregulation of the Src/JNK/AP1 and PI3K/Akt/NF-κB pathways and suppression of the PI3K/Akt/mTOR pathway

Cheng, C.-Y., Tseng, H.-H., Chiu, H., Chang, C., Nielsen, B. L., & Liu, H. (2019) · Veterinary Research · doi:10.1186/s13567-019-0697-0 · Cited by 25

SHP-2 Regulates Cell Growth by Controlling the mTOR/S6 Kinase 1 Pathway

Zito, C. I., Hui, Q., Blenis, J., & Bennett, A. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608338200 · Cited by 26

Activation of signaling pathways and regulatory mechanisms of mRNA translation following myocardial ischemia-reperfusion

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Nelfinavir and Ritonavir Kill Bladder Cancer Cells Synergistically by Inducing Endoplasmic Reticulum Stress

Sato, A., Asano, T., Okubo, K., Isono, M., & Asano, T. (2017) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504017x14957929842972 · Cited by 26

Rapamycin inhibits lung squamous cell carcinoma growth by downregulating glypican-3/Wnt/β-catenin signaling and autophagy

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The Inhibition of Insulin-stimulated Proliferation of Vascular Smooth Muscle Cells by Rosiglitazone Is Mediated by the Akt-mTOR-P70S6K Pathway

Park, S., Lim, S., Chang, W., Song, H., Lee, S., Song, B., Kim, H., Cha, M., Choi, E.-J., Jang, Y., et al. (2008) · Yonsei Medical Journal · doi:10.3349/ymj.2008.49.4.592 · Cited by 22

TIF-IA: An oncogenic target of pre-ribosomal RNA synthesis

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Mechanisms of Dietary Restriction in Aging and Disease

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Hierarchical inhibition of mTORC1 by glucose starvation-triggered AXIN lysosomal translocation and by AMPK

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Glutamate improves flesh quality and muscle growth of triploid crucian carp

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The Protein and Energy Metabolic Response of Skeletal Muscle to the Low-Protein Diets in Growing Pigs

Li, Y., Li, F., Duan, Y., Guo, Q., Wang, W., Wen, C., Huang, X., & Yin, Y. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02461 · Cited by 22

Inhibition of mTOR/S6K1/4E-BP1 Signaling by Nutraceutical SIRT1 Modulators

Bianchi, S. E., & Giovannini, L. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1446093 · Cited by 20

Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells

Liu, H., Kurtoğlu, M., Cao, Y., Xi, H., Kumar, R., Axten, J. M., & Lampidis, T. J. (2013) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-013-2193-y · Cited by 21

A two-dimensional screen for AMPK substrates identifies tumor suppressor fumarate hydratase as a preferential AMPKα2 substrate

Klaus, A., Polge, C., Zorman, S., Auchli, Y., Brunisholz, R., & Schlattner, U. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.03.040 · Cited by 19

Loss of thioredoxin 2 alters mitochondrial respiratory function and induces cardiomyocyte hypertrophy

Hu, C., Zhang, H., Qiao, Z., Wang, Y., Zhang, P., & Yang, D. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.09.010 · Cited by 20

The interplay of microRNAs and transcription factors in autophagy regulation in nonalcoholic fatty liver disease

Kim, Y., Lee, D.-H., Park, S., Jeon, T., & Jung, C. H. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00611-0 · Cited by 19

hepaCAM and p-mTOR Closely Correlate in Bladder Transitional Cell Carcinoma and hepaCAM Expression Inhibits Proliferation via an AMPK/mTOR Dependent Pathway in Human Bladder Cancer Cells

Wang, Q., Luo, C., Wu, X., Du, H., Song, X., & Fan, Y. (2013) · The Journal of Urology · doi:10.1016/j.juro.2013.05.013 · Cited by 19

Tissue-specific regulation of protein synthesis by insulin and free fatty acids

Crozier, S. J., Anthony, J. C., Schworer, C. M., Reiter, A. K., Anthony, T. G., Kimball, S. R., & Jefferson, L. S. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00063.2003 · Cited by 18

Effects of Metformin and Vitamin D on Clinical Outcome in Cholangiocarcinoma Patients

Gardini, A. C., Filippi, R., Rimini, M., Rapposelli, I. G., Fornaro, L., Silvestris, N., Aldrighetti, L. A., Aimar, G., Rovesti, G., Bartolini, G., et al. (2021) · Oncology · doi:10.1159/000512796 · Cited by 18

Metformin and asarone inhibit HepG2 cell proliferation in a high glucose environment by regulating AMPK and Akt signaling pathway

Das, B. K., Knott, R. M., & Gadad, P. C. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-021-00193-8 · Cited by 17

Natural products targeting macroautophagy signaling in hepatocellular carcinoma therapy: Recent evidence and perspectives

Chen, Y., Tan, X., Zhang, W., Li, Y., Deng, X., Zeng, J., Huang, L., & Ma, X. (2024) · Phytotherapy Research · doi:10.1002/ptr.8103 · Cited by 17

Mammalian Target of Rapamycin Complex 1 (mTORC1) Plays a Role in Pasteurella multocida Toxin (PMT)-induced Protein Synthesis and Proliferation in Swiss 3T3 Cells

Oubrahim, H., Wong, A. W., Wilson, B. A., & Chock, P. B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.427351 · Cited by 17

Molecular mechanisms of synergistic induction of apoptosis by the combination therapy with hyperthermia and cisplatin in prostate cancer cells

Zhang, J.-F., Yan, X., Lan, B., Lei, Y., Li, X., Gao, S., Guo, Y., & Guo, F. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.060 · Cited by 17

Dietary restriction regimens for fighting kidney disease: Insights from rodent studies

Singh, G., & Krishan, P. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110738 · Cited by 16

Risk Stratification in Multiple Myeloma

Ooi, M. G. M., Mel, S. D., & Chng, W. J. (2016) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-016-0307-4 · Cited by 16

Potential upstream regulators and downstream targets of AMP-activated kinase signaling during oocyte maturation in a marine worm

Stricker, S. A. (2011) · Reproduction · doi:10.1530/rep-10-0509 · Cited by 18

Impact of diabetes on the increased risk of hepatic cancer: An updated review of biological aspects

Das, B. K., & Gadad, P. C. (2021) · Diabetes Epidemiology and Management · doi:10.1016/j.deman.2021.100025 · Cited by 15

Effect of metformin on residual cells after chemotherapy in a human lung adenocarcinoma cell line

Kitazono, S., Takiguchi, Y., Ashinuma, H., Kitazono, M., Kitamura, A., Chiba, T., Sakaida, E., Sekine, I., Tada, Y., Kurosu, K., et al. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2120 · Cited by 16

Manipulating bovine granulosa cell energy metabolism limits inflammation

Horlock, A. D., Ormsby, T. J. R., Clift, M. J. D., Santos, J. E. P., Bromfield, J. J., & Sheldon, I. M. (2021) · Reproduction · doi:10.1530/rep-20-0554 · Cited by 15

Protective Macroautophagy Is Involved in Vitamin E Succinate Effects on Human Gastric Carcinoma Cell Line SGC-7901 by Inhibiting mTOR Axis Phosphorylation

Hou, L., Li, Y., Huacui, S., Zhang, Z., Sun, Y., Zhang, X., & Wu, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132829 · Cited by 15

Effect of Dietary Nonstructural Carbohydrate Content on Activation of 5′-Adenosine Monophosphate-Activated Protein Kinase in Liver, Skeletal Muscle, and Digital Laminae of Lean and Obese Ponies

Burns, T. A., Watts, M. R., Weber, P. S. D., McCutcheon, L. J., Geor, R. J., & Belknap, J. K. (2014) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12356 · Cited by 15

Mining of chicken muscle growth genes and the function of important candidate gene RPL3L in muscle development

Lin, S., Xian, M., Ren, T., Mo, G., Zhang, L., & Zhang, X. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1033075 · Cited by 16

microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation

Li, Z., Zhu, Y.-R., Zhou, X., Zhuo, B., & Wang, X. (2017) · Oncotarget · doi:10.18632/oncotarget.15477 · Cited by 13

Glucose deprivation promotes activation of mTOR signaling pathway and protein synthesis in rat skeletal muscle cells

Miniaci, M. C., Dattolo, M. G., Irace, C., Capuozzo, A., Santamaria, R., & Scotto, P. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1583-2 · Cited by 10

Pleiotropic Effects of Metformin in Osteoarthritis

Lambova, S. N. (2023) · Life · doi:10.3390/life13020437 · Cited by 12

Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes

Møller, M. T. N., Samari, H. R., Fengsrud, M., STRØMHAUG, P. E., Østvold, A. C., & Seglen, P. O. (2003) · Biochemical Journal · doi:10.1042/bj20030502 · Cited by 12

Far-Infrared Irradiation Decreases Proliferation in Basal and PDGF-Stimulated VSMCs Through AMPK-Mediated Inhibition of mTOR/p70S6K Signaling Axis

Hwang, Y., Park, J., & Cho, D. (2023) · Journal of Korean Medical Science · doi:10.3346/jkms.2023.38.e335 · Cited by 11

Metabolic Biomarkers in Nematode C. elegans During Aging

Yanase, S., Ishii, T., Yasuda, K., & Ishii, N. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-12668-1_9 · Cited by 10

Energy-Sensing Pathways in Ischemia: The Counterbalance Between AMPK and mTORC

Céspedes-Rubio, Á. E., Villa, M., Benito‐Cuesta, I., Pérez-Álvarez, M. J., Ordóñez‐Gutiérrez, L., & Wandosell, F. G. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191210152156 · Cited by 11

Toxin-Induced Tail Phosphorylation of Hepatocellular S6 Kinase: Evidence for a Dual Involvement of the AMP-Activated Protein Kinase in S6 Kinase Regulation

Møller, M. T. N. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh273 · Cited by 11

Cytoplasmic signaling in the control of mitochondrial uproar?

Hermann, M., Kuznetsov, A. V., Maglione, M., Smigelskaite, J., Margreiter, R., & Troppmair, J. (2008) · Cell Communication and Signaling · doi:10.1186/1478-811x-6-4 · Cited by 11

Acetyl-CoA carboxylase inhibition regulates microtubule dynamics and intracellular transport in cystic fibrosis epithelial cells

Rymut, S. M., Lu, B., Perez, A., Corey, D. A., Lamb, K., Cotton, C. U., & Kelley, T. J. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00369.2018 · Cited by 10

2-Arylthiazolidine-4-carboxylic acid amides (ATCAA) target dual pathways in cancer cells: 5'-AMP-activated protein kinase (AMPK)/mTOR and PI3K/Akt/mTOR pathways

Dalton (2010) · International Journal of Oncology · doi:10.3892/ijo_00000754 · Cited by 10

Metformin inhibits polyphosphate-induced hyper-permeability and inflammation

Asgharzadeh, F., Barneh, F., Fakhraie, M., barkhordar, S. L. A., Shabani, M., Soleimani, A., Rahmani, F., Ariakia, F., Mehraban, S., Avan, A., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107937 · Cited by 10

Mammalian Target of Rapamycin (mTOR)

Yonezawa, K. (2005) · doi:10.1007/4-431-27172-4_8 · Cited by 10

Tea ( Camellia sinensis ) Seed Saponins Act as Sebosuppression Agents via the AMPK / mTOR Pathway

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Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells

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