Cited by 30Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Nectandrin B-mediated activation of the AMPK pathway prevents cellular senescence in human diploid fibroblasts by reducing intracellular ROS levels

Open access
Jang, Hyun-Jin, Yang, Kyeong Eun, Oh, Won Keun, Lee, Song-I, Hwang, In-Hu, Ban, Kyung-Tae, Yoo, Hwa-Seung, Choi, Jong-Soon +2 more·2019·Aging

Abstract

, reduced cellular ROS levels, and increased antioxidant enzymes in old HDFs. Moreover, NecB-mediated activation of the AMPK pathway reduced intracellular ROS levels. These results suggest that NecB-induced protection against cellular senescence is mediated by ROS-scavenging through activation of AMPK. NecB might be useful in ameliorating age-related diseases and extending human lifespan.

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Authors
Jang, H.-J., Yang, K. E., Oh, W. K., Lee, S.-I., Hwang, I.-H., Ban, K.-T., Yoo, H.-S., Choi, J.-S., Yeo, E.-J., & Jang, I.-S.
Affiliations
  • Korea Basic Science Institute (KR)
  • Seoul National University (KR)
  • Gachon University (KR)
  • Korea University (KR)
  • Daejeon University (KR)
Corresponding author
  • Yeo, Eui-Ju
  • Jang, Ik-Soon
Venue
Aging
Published
2019-06-14
Volume
11
Issue
11
Pages
3731-3749
ISSN
1945-4589 (ISSN-L)
OpenAlex
W2950622326
Cited by
30
References
66
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 9 · 2022: 9 · 2021: 3 · 2020: 3
FWCI
2.57
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Aging (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords
AMPK signaling, cellular senescence, reactive oxygen species, antioxidant enzymes, human diploid fibroblasts, age-related diseases, lifespan extension, natural products
MeSH terms
Adenylate Kinase, Cell Cycle, Cell Survival, Diploidy, Fibroblasts, Humans, Phosphorylation, Signal Transduction, Cellular Senescence, Reactive Oxygen Species, Lignans, Cyclin D1, Sirtuins

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