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Ovarian atypical endometriosis: its close association with malignant epithelial tumours
Abstract
The incidence of ovarian atypical endometriosis and its association with malignant epithelial tumours in a consecutive series of cases during the period 1987 to 1995 were studied. Atypical glandular changes were observed in four (1.7%) of 255 ovarian endometriosis cases and one patient with ovarian atypical endometriosis developed subsequent endometrioid carcinoma in the abdominal wall. Fifty-four (24.1%) of the 224 ovarian cancers were associated with ovarian endometriosis; 21 with typical and 33 with atypical endometriosis. Clear cell carcinomas and endometrioid carcinomas were most frequently associated with endometriosis, with 54% (27 of 50 cases) and 41.9% (13 of 31), respectively. Atypical endometriosis was found in 18 clear cell carcinomas, in seven endometrioid carcinomas, in four serous carcinomas, in three mucinous borderline tumours, and in one serous borderline tumour. In 13 cases, the atypical endometriosis was in contiguity with malignant epithelial tumours. We consider that atypical endometriosis possesses a precancerous potential or is most frequently associated with clear cell and endometrioid carcinomas. Close screening of cellular atypia or hyperplasia in ovarian endometriosis and careful long-term follow-up of patients with atypical endometriosis is required.
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“One of the reasons is that 14.7 to 22.8% of ovarian carcinomas coexist with atypical endometriosis [13,14].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [13]
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Items 301–336 of 336
Endometrioid Ovarian Carcinomas
Hirschowitz, L. (2014) · Springer eBooks · doi:10.1007/978-1-4471-2942-4_11
“9 % of cases [ 19 – 23 ], and an association with atypical endometriosis is recognized [ 20 ].”
BackgroundPathology of Clear Cell Tumors
Soslow, R. A., & DeLair, D. F. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9751-7_8
Clinical Management of Selected Precancerous Lesions of the Uterus, Fallopian Tube, and Ovary
Stickles, X. B. (2015) · Springer eBooks · doi:10.1007/978-3-319-22509-8_4
Precancerous Lesions of Ovarian Clear Cell and Endometrioid Carcinomas
Roma, A. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-22509-8_3
Zaloudek, C. Z., & Garg, K. (2015) · Cambridge University Press eBooks · doi:10.1017/9781139137201.040
Endometrioid Carcinoma of the Ovary
Cock, L. D., Avérous, G., Barthélémy, P., & Kurtz, J. (2016) · Springer eBooks · doi:10.1007/978-3-319-32110-3_15
Soslow, R. A. (2009) · Elsevier eBooks · doi:10.1016/b978-044306920-8.50019-5
Ovarian Endometrioid and Clear-Cell Tumors
Katzenberg, J., & Roma, A. A. (2019) · Springer eBooks · doi:10.1007/978-981-13-3019-3_6
Endometriosis and Endometriosis-Associated Tumors
Simmen, R. C. M., Quick, C. M., Kelley, A. S., & Zheng, W. (2019) · Springer eBooks · doi:10.1007/978-981-13-3019-3_12
Russell, D. H. (2020) · AJSP Review and Reports · doi:10.1097/pcr.0000000000000409
Ovarian Endometriosis and Malignant Transformation in Clear Cell Carcinoma
Maria, M. I., & Cornel, M. A. (2020) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.2478/amma-2020-0023
“Usually the atypia can be mild, but sometimes can be severe with unifocal, multifocal or diffuse foci [8].”
BackgroundFaruqi, A. Z. (2014) · Springer eBooks · doi:10.1007/978-1-4471-2942-4_18
Beckmann, M. W. (2022) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-1684-2623
Irving, J. A., & Clement, P. B. (2018) · Springer eBooks · doi:10.1007/978-1-4614-3165-7_13-2
Nascimento, A. F., & Nucci, M. R. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0764-9.00023-8 · Cited by 2
Paillocher, N., Paris, L., Boussion, F., Cotici, V., Croué, A., Anglade, E., Catala, L., & Descamps, P. (2006) · EMC - Gynécologie · doi:10.1016/s0246-1064(06)44375-9
Malignancy Risks Associated with Endometriosis: Clinical Aspects
Schmädecker, R., & Ulrich, U. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-97236-3_24
Du, Y., Hu, Y., Zhang, F., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2542861/v1
Tumor-Like Lesions and Endometriosis, Pathology of the Peritoneum
Djordjevic, B. (2023) · Encyclopedia of pathology · doi:10.1007/978-3-319-28845-1_5679-1
Ke, X., Liang, X.-F., & Wang, F. (2023) · International Journal of Women s Health · doi:10.2147/ijwh.s431837
Tumor-Like Lesions and Endometriosis, Pathology of the Peritoneum
Djordjevic, B. (2023) · Encyclopedia of pathology · doi:10.1007/978-3-030-97378-0_5679
Faruqi, A. Z. (2023) · Essentials of Diagnostic Gynecological Pathology. · doi:10.1007/978-3-031-39659-5_23
Wang, T., Hirschowitz, L., & Carlson, J. W. (2023) · Essentials of Diagnostic Gynecological Pathology. · doi:10.1007/978-3-031-39659-5_18
Ovarian Endometrioid and Clear-Cell Tumors
Roma, A. A. (2024) · Springer eBooks · doi:10.1007/978-981-19-7696-4_6-1
10.1016/b978-0-323-26339-9.00035-4
(2000) · Time to knit · doi:10.1016/b978-0-323-26339-9.00035-4
Deng, J. F., Li, J., Xu, L., & Yi, T. (2025) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-025-08025-3
“According to Sampson and Scott criteria, “arising from” cases exhibit malignant transformation, with A-EMS as the precancerous lesion for OCCC [31].”
Influential“Early” Clear Cell Proliferations (Clear Cell Carcinoma in Situ) in Ovarian Endometriotic Cysts
Karunadhas, N. S., Catherwood, M. A., Stringfellow, H. F., et al. (2025) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000002415
Leenen, S., Kooreman, L. F. S., Bulten, J., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5263731
Endometriosis and Endometriosis-Associated Tumors
Simmen, R. C. M., Quick, C. M., & Zheng, W. (2025) · Springer eBooks · doi:10.1007/978-981-97-4822-8_12
Ovarian Endometrioid and Clear-Cell Tumors
Roma, A. A. (2025) · Springer eBooks · doi:10.1007/978-981-97-4822-8_6
Leenen, S., Kooreman, L. F. S., Bulten, J., van Esch, E. M. G., van Steenwijk, P. J. D. V., Nieboer, T. E., Bekkers, R. L. M., & van Altena, A. M. (2025) · Human Pathology · doi:10.1016/j.humpath.2025.105875
Hamutoğlu, R., Kaloğlu, C., Bulut, H. E., & Yıldız, Ç. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1625031
Research Progress on Endometriosis-Associated Ovarian Cancer
余, 平. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1651847
Three-Dimensional Ultrasonography in Endometriosis
Guerriero, S., Pedrassani, M., Simon, L. S., Carta, G., AJOSSA, S., Pagliuca, M., Deiala, F., Pascual, M. A., Graupera, B., Saba, L., et al. (2026) · Springer eBooks · doi:10.1007/978-3-032-19697-2_9
Endometrioma: Computed Tomography and Magnetic Resonance Imaging
Saba, L., Sulcis, R., Spiga, S., Piga, M., Suri, J. S., AJOSSA, S., & Guerriero, S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8633-6_5
“There are few papers describing this condition in the literature, and in each of these cases, there was a mass with cystic component containing polypoidal areas that were hyperintense on T2-weighted image and demonstrated homogeneous enhancement after administration of contrast material [ 69 , 77 , 78 ].”
Background
Metadata
- Authors
- FUKUNAGA, M., NOMURA, K., ISHIKAWA, E., & USHIGOME, S.
- Affiliations
- Jikei University School of Medicine (JP)
- Corresponding author
- FUKUNAGA, M.
- ORCID
- FUKUNAGA, M.
- Venue
- Histopathology
- Publisher
- Wiley
- Published
- 1997-03
- Volume
- 30
- Issue
- 3
- Pages
- 249-255
- ISSN
- 0309-0167 (ISSN-L)
- 1365-2559
- OpenAlex
- W2084264037
- Cited by
- 333
- References
- 0
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 19 · 2017: 8 · 2016: 10 · 2015: 17 · 2014: 17 · 2013: 14 · 2012: 22
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Histopathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometrioma, endometrioid carcinoma, clear cell carcinoma, ovarian cancer, serous carcinoma, serous borderline tumor, long-term follow-up
- MeSH terms
- Adult, Carcinoma, Endometriosis, Female, Humans, Middle Aged, Ovarian Diseases, Ovarian Neoplasms
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