Cited by 336Endometriosis Research and TreatmentOvarian cancer diagnosis and treatmentEndometrial and Cervical Cancer Treatments

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Ovarian atypical endometriosis: its close association with malignant epithelial tumours

FUKUNAGA, M., NOMURA, K., ISHIKAWA, E., USHIGOME, S.·1997·Histopathology

DOI 10.1046/j.1365-2559.1997.d01-592.x

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Abstract

The incidence of ovarian atypical endometriosis and its association with malignant epithelial tumours in a consecutive series of cases during the period 1987 to 1995 were studied. Atypical glandular changes were observed in four (1.7%) of 255 ovarian endometriosis cases and one patient with ovarian atypical endometriosis developed subsequent endometrioid carcinoma in the abdominal wall. Fifty-four (24.1%) of the 224 ovarian cancers were associated with ovarian endometriosis; 21 with typical and 33 with atypical endometriosis. Clear cell carcinomas and endometrioid carcinomas were most frequently associated with endometriosis, with 54% (27 of 50 cases) and 41.9% (13 of 31), respectively. Atypical endometriosis was found in 18 clear cell carcinomas, in seven endometrioid carcinomas, in four serous carcinomas, in three mucinous borderline tumours, and in one serous borderline tumour. In 13 cases, the atypical endometriosis was in contiguity with malignant epithelial tumours. We consider that atypical endometriosis possesses a precancerous potential or is most frequently associated with clear cell and endometrioid carcinomas. Close screening of cellular atypia or hyperplasia in ovarian endometriosis and careful long-term follow-up of patients with atypical endometriosis is required.

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BackgroundMethod
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Background
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Background
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Background
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Influential
Predictive factors of endometriosis progression into ovarian cancer
Varga, J., Reviczká, A., Háková, H., Švajdler, P., Rabajdová, M., & Ostro, A. (2022) · Journal of Ovarian Research · doi:10.1186/s13048-021-00940-8 · Cited by 24
Atypical Endometriosis: Comprehensive Characterization of Clinicopathologic, Immunohistochemical, and Molecular Features
Wepy, C., Nucci, M. R., & Parra‐Herran, C. (2023) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0000000000000952 · Cited by 22
“…(A-EMS) is de ﬁ ned by the World Health Organization as EMS with a localized proliferation of crowded glands lined by atypical epithelium resembling endometrial intraepithelial neoplasia, or alteration in endometriotic cyst lining with strati ﬁ cation, disorganization and cytologic atypia (4).”
Background
Rsf-1 (HBXAP) Expression is Associated With Advanced Stage and Lymph Node Metastasis in Ovarian Clear Cell Carcinoma
Maeda, D., Xu, C., Guan, B., et al. (2010) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e3181e9a319 · Cited by 21
Clinical manifestations in patients with ovarian clear cell carcinoma with or without co-existing endometriosis
Lim, M. C., Lee, D. O., Kang, S., et al. (2009) · Gynecological Endocrinology · doi:10.1080/09513590902770131 · Cited by 21
Ovarian cancer: new developments in clear cell carcinoma and hopes for targeted therapy
Yamashita, Y. (2015) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyu221 · Cited by 21
The “Road” to Malignant Transformation from Endometriosis to Endometriosis-Associated Ovarian Cancers (EAOCs): An mTOR-Centred Review
Hablase, R., Kyrou, I., Randeva, H. S., Karteris, E., & Chatterjee, J. (2024) · Cancers · doi:10.3390/cancers16112160 · Cited by 24
“The concept of “atypical endometriosis” evolved over time, describing a non-invasive intermediate stage characterized by cytological atypia and architectural disorganization [99].”
Background
Developments in the pathology of ovarian tumours
Chapman, W. B. (2001) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-200102000-00008 · Cited by 20
Genetic Links between Endometriosis and Endometriosis-Associated Ovarian Cancer—A Narrative Review (Endometriosis-Associated Cancer)
Pejovic, T. B., Cathcart, A. M., Alwaqfi, R., Brooks, M. N., Kelsall, R., & Nezhat, F. R. (2024) · Life · doi:10.3390/life14060704 · Cited by 22
“Histologic EAOC specimens have been identified to demonstrate a continuum of transition from benign to atypical endometriosis to EAOC [42,43,45–47].”
Background
Factors in malignant transformation of ovarian endometriosis: A narrative review
Giannini, A., Massimello, F., Caretto, M., Cosimi, G., Mannella, P., Luisi, S. V., Gadducci, A., & Simoncini, T. (2024) · Gynecological Endocrinology · doi:10.1080/09513590.2024.2409911 · Cited by 23
“They seem to be involved in the capacity of endometrial cells to survive, implant and invade peritoneal and ovarian tissues [23,45,46].”
Influential
Nanotechnology-Based Nucleic Acid Vaccines for Treatment of Ovarian Cancer
Gildiz, S., & Minko, T. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03434-4 · Cited by 19
Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review)
Zhang, W., Li, K., Jian, A., Zhang, G., & Zhang, X. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13422 · Cited by 25
“Although EM is recognized as benign cell proliferation, it has characteristics similar to malignant tumors, such as progressive and invasive growth, genetic instability, excessive proliferation, estrogen‑dependent growth and a tendency to metastasize (6).”
Aberrant Expression of the Mammalian Target of Rapamycin, Hypoxia-inducible Factor-1α, and Glucose Transporter 1 in the Development of Ovarian Clear-cell Adenocarcinoma
Kato, M., Yamamoto, S., Takano, M., Matsubara, O., & Furuya, K. (2012) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e318237d66c · Cited by 19
“According to the previously described criteria for atypical endometriosis (29,31), lesions of (A) and (B) were defined as nonatypical and atypical endometriosis, respectively.”
BackgroundMethod
Endometrioid adenocarcinoma of the ovary arising in atypical endometriosis.
Terada, T. (2012) · PubMed · Cited by 19
Evidence for ethnic and environmental contributions to frequency of ovarian clear cell carcinoma
Tay, S. K., & Cheong, M. A. (2014) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.12188 · Cited by 19
Fine-needle aspiration in the management of peripheral lymphadenopathy in a developing country
(1999) · doi:10.1002/(sici)1097-0339(199909)21:3
Immunochemical analysis of iron transporters and M2 macrophages in ovarian endometrioma and clear cell adenocarcinoma
Akashi, K., Nagashima, Y., Tabata, T., & Oda, H. (2021) · Molecular and Clinical Oncology · doi:10.3892/mco.2021.2321 · Cited by 18
“The prevalence of EAOC will likely increase along with that of endometriosis; however, the underlying mechanisms associated with carcinogen‑ esis are controversial.”
BackgroundInfluential
Primary ovarian adenocarcinoma developing in ovarian remnant tissue ten years after laparoscopic hysterectomy and bilateral salpingo-oophorectomy for endometriosis
Donnez, O., Squifflet, J. P., Marbaix, É., Jadoul, P., & Donnez, J. (2007) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2007.05.005 · Cited by 17
Imaging in gynaecology: How good are we in identifying endometriomas?
Holsbeke, C. S. V., CALSTER, B. V., Guerriero, S., Savelli, L., Leone, F. P. G., Fischerová, D., Czekierdowski, A., Fruscio, R., Veldman, J., G, V. D. P., et al. (2009) · PubMed Central · Cited by 17
Treatment of early epithelial ovarian cancer with chemotherapy and abdominopelvic radiotherapy: results of a prospective treatment protocol
Wong, R. K. W., Milosevic, M., Sturgeon, J. F. G., et al. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)00227-8 · Cited by 17
Ovarian endometrioid adenocarcinoma arising from endometriosis in a young woman
Tagashira, Y., Shimada, M., Kigawa, J., Iba, T., & Terakawa, N. (2003) · Gynecologic Oncology · doi:10.1016/j.ygyno.2003.08.005 · Cited by 17
Long-Term Follow-Up after Surgical Management for Atypical Endometriosis: A Series of Nine Cases
Tanase, Y., Kawaguchi, R., Uchiyama, T., & Kobayashi, H. (2019) · Case Reports in Oncology · doi:10.1159/000496178 · Cited by 16
Surgical challenges in the treatment of perimenopausal and postmenopausal endometriosis
Özyürek, E. Ş., Yoldemir, T., & Kalkan, Ü. (2018) · Climacteric · doi:10.1080/13697137.2018.1439913 · Cited by 16
IL6, IL8, and IL10 in the distinction of malignant ovarian neoplasms and endometriomas
Crispim, P. C. A., Jammal, M. P., Antão, P. K. A., Micheli, D. C., Tavares‐Murta, B. M., Murta, E. F. C., & Nomelini, R. S. (2020) · American Journal of Reproductive Immunology · doi:10.1111/aji.13309 · Cited by 16
Endometriosis-related ovarian neoplasms: pathogenesis and histopathologic features
Mikami, Y. (2014) · Diagnostic histopathology · doi:10.1016/j.mpdhp.2014.07.002 · Cited by 16
Laparoscopic Treatment of Endometrioma-Associated Infertility and Pregnancy Outcome
Takuma, N., Sengoku, K., Pan, B., Wada, K., Yamauchi, T., Miyamoto, T., Ohsumi, D., & Ishikawa, M. (2002) · Gynecologic and Obstetric Investigation · doi:10.1159/000066292 · Cited by 15
Analysis of common variations in tumor-suppressor genes on chr1p36 among Caucasian women with endometriosis
Falconer, H., Sundqvist, J., Xu, H., Vodolazkaia, A., Fassbender, A., Kyama, C. M., Bokor, A., & D’Hooghe, T. M. (2012) · Gynecologic Oncology · doi:10.1016/j.ygyno.2012.08.013 · Cited by 14
“Although several authors have described a transition from benign into atypical endometriosis, reports on the early events required for invasive transformation have been limited [7,10].”
Background
Infiltrating T lymphocytes and programmed cell death protein-1/programmed death-ligand 1 expression in endometriosis-associated ovarian cancer
Nero, C., Romito, I., Spadola, S., Romito, A., Turco, L. C., Cosentino, F., Ninno, M. D., Catena, U., Nardone, A. D. C., Moroni, R., et al. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.08.032 · Cited by 14
Discovery of Prognostic Factors for Diagnosis and Treatment of Epithelial-Derived Ovarian Cancer from Laying Hens
Lim, W., & Song, G. (2013) · Journal of Cancer Prevention · doi:10.15430/jcp.2013.18.3.209 · Cited by 14
“associated with endometriosis due to genetic alterations and hyperplasia of the endometrium.(23,24) In addition, endometrioid carcinomas have glands, solid masses or a”
Background
Demographic, Clinical, and Prognostic Factors of Ovarian Clear Cell Adenocarcinomas According to Endometriosis Status
Schnack, T. H., Høgdall, E. V. S., Thomsen, L. N., et al. (2017) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000001102 · Cited by 14
Alpha‐fetoprotein producing ovarian clear cell carcinoma with a neometaplasia to hepatoid carcinoma arising from endometriosis: A case report
Takahashi, Y., Mogami, H., Hamada, S., et al. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2011.01622.x · Cited by 13
Increased steroid receptor RNA activator protein (SRAP) accompanied by decreased estrogen receptor-beta (ER-β) levels during the malignant transformation of endometriosis associated ovarian clear cell carcinoma
Lin, K., Zhan, H., Ma, J., Xu, K., Wu, R., Zhou, C., & Lin, J. (2014) · Acta Histochemica · doi:10.1016/j.acthis.2014.02.007 · Cited by 13

Authors: FUKUNAGA, M., NOMURA, K., ISHIKAWA, E., & USHIGOME, S.
Affiliations: Jikei University School of Medicine (JP)
Corresponding author: FUKUNAGA, M.
ORCID: FUKUNAGA, M.
Venue: Histopathology
Publisher: Wiley
Published: 1997-03
Volume: 30
Issue: 3
Pages: 249-255
ISSN: 0309-0167 (ISSN-L)
1365-2559
DOI: 10.1046/j.1365-2559.1997.d01-592.x
OpenAlex: W2084264037
Cited by: 333
References: 0
Citations by year: 2026: 5 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 19 · 2017: 8 · 2016: 10 · 2015: 17 · 2014: 17 · 2013: 14 · 2012: 22
FWCI: 4.72
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2434 d)
Locations: Histopathology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords: endometrioma, endometrioid carcinoma, clear cell carcinoma, ovarian cancer, serous carcinoma, serous borderline tumor, long-term follow-up
MeSH terms: Adult, Carcinoma, Endometriosis, Female, Humans, Middle Aged, Ovarian Diseases, Ovarian Neoplasms

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Ovarian atypical endometriosis: its close association with malignant epithelial tumours

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