Cited by 122T-cell and B-cell ImmunologyGut microbiota and healthGastrointestinal motility and disorders

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Microbial colonization influences composition and T‐cell receptor Vβ repertoire of intraepithelial lymphocytes in rat intestine

HELGELAND, L., VAAGE, J. T., ROLSTAD, B., MIDTVEDT, T., BRANDTZAEG, P.·1996·Immunology

DOI 10.1046/j.1365-2567.1996.d01-783.x

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Abstract

Studies in mice have shown that the composition of intestinal intraepithelial lymphocytes (IEL) may be markedly altered by gut microbial colonization. Such modulation was studied in a rat model by the use of germ-free and conventionalized animals from which IEL from the small intestine were isolated and analysed by flow cytometry. Conventionalization caused expansion as well as phenotypic alterations of T-cell receptor (TCR) alpha/beta + IEL in that the proportions of CD4+ and CD8 alpha beta + TCR alpha/beta + cells were increased, while the double negative (CD4- CD8-) fraction was reduced. microbial colonization also influenced the TCR V beta repertoire of CD8+ IEL in that the proportions of V beta 8.2+ and V beta 10+ cells were increased, whereas V beta 8.5+ and V beta 16+ cells were relatively decreased. Moreover, conventionalization influenced the levels of TCR cell surface expression in the same V beta subsets. Three-colour flow-cytometric analysis demonstrated that skewing of the V beta repertoire was most pronounced in the CD8 alpha alpha + subset, although the numerical increase of IEL mainly included the CD8 alpha beta + subset. In contrast to IEL, the TCR V beta repertoire in mesenteric lymph nodes was unchanged after intestinal colonization. These results confirm that TCR alpha/beta + IEL subpopulations respond dynamically to the microbial gut flora and suggest that their V beta repertoire can be shaped by luminal microbial antigens.

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Authors: HELGELAND, L., VAAGE, J. T., ROLSTAD, B., MIDTVEDT, T., & BRANDTZAEG, P.
Affiliations: University of Oslo (NO)
Karolinska Institutet (SE)
Pathologisches Institut (DE)
Corresponding author: HELGELAND, L.
ORCID: VAAGE, J. T.
BRANDTZAEG, P.
Venue: Immunology
Publisher: Wiley
Published: 1996-12
Volume: 89
Issue: 4
Pages: 494-501
ISSN: 0019-2805 (ISSN-L)
1365-2567
DOI: 10.1046/j.1365-2567.1996.d01-783.x
OpenAlex: W2040231886
Cited by: 122
References: 37
Citations by year: 2026: 1 · 2025: 5 · 2024: 3 · 2023: 1 · 2021: 3 · 2020: 4 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 8 · 2013: 3 · 2012: 8
FWCI: 1.51
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2524 d)
Locations: Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Norges Forskningsråd
Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: intraepithelial lymphocytes, gut microbiota, microbial colonization, T cell receptor V beta repertoire, germ-free rats, conventionalization, CD4+ T cells, double-negative T cells, mesenteric lymph nodes, small intestine
MeSH terms: Animals, Flow Cytometry, Germ-Free Life, Intestinal Mucosa, Lymphocyte Activation, Male, Mesentery, Rats, Inbred Strains, T-Lymphocytes, CD4-Positive T-Lymphocytes, Receptors, Antigen, T-Cell, alpha-beta, CD8-Positive T-Lymphocytes, Immunity, Mucosal, Rats

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Microbial colonization influences composition and T‐cell receptor Vβ repertoire of intraepithelial lymphocytes in rat intestine

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