Dietary Inulin Improves Distal Colitis Induced by Dextran Sodium Sulfate in the Rat
Abstract
Objectives Inulin stimulates intracolonic generation of butyrate and growth of lactic acid bacteria. This study investigated whether inulin protects against colitis. Methods Rats with dextran sodium sulfate colitis received inulin either orally (1% in drinking water, or 400 mg/day) or by enema. Matched groups received vehicle. In addition, fecal water obtained from inulin-fed rats was administered by enema to rats with colitis and compared with fecal water from control rats. Finally, rats with colitis received daily enemas of either butyrate (at 40 or 80 mmol/L) or vehicle. Inflammation was assessed by eicosanoid asssay in rectal dialysates and MPO activity in colonic tissue. Mucosal lesions were blindly scored by microscopic examination. Luminal pH was measured from cecum to rectum by a surface microelectrode. Results Oral inulin prevented inflammation, as evidenced by lower lesion scores (p Conclusions Oral inulin reduces the severity of dextran sodium sulfate colitis. The effect seems to be mediated by modification of the intracolonic milieu.
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Administration of inulin to a dextran sulfate sodium-induced colitis mouse model attenuated colitis symptoms and increased Lactobacillus composition.
“Furthermore, administration of inulin to a dextran sulfate sodium-induced colitis mouse model resulted in an attenuation of the colitis symptoms in addition to an increase in Lactobacillus composition (Videla et al., 2001).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Videla et al., 2001
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- Authors
- Videla, S., Vilaseca, J., Antolín, M., García-Lafuente, A., Guarner, F., Crespo, E., Casalots, J., Salas, A., & Malagelada, J. R.
- Affiliations
- Vall d'Hebron Hospital Universitari (ES)
- University Hospital Mútua de Terrassa (ES)
- Corresponding author
- Guarner, Francisco
- Venue
- American Journal of Gastroenterology
- Published
- 2001-05
- Volume
- 96
- Issue
- 5
- Pages
- 1486-1493
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2036059068
- Cited by
- 209
- References
- 1
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 12 · 2022: 7 · 2021: 10 · 2020: 5 · 2019: 11 · 2018: 9 · 2017: 6 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 6 · 2012: 16
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Comisión Interministerial de Ciencia y Tecnología
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- inulin, DSS-induced colitis, distal colitis, butyrate, lactic acid bacteria, lactobacilli, fecal water, mucosal inflammation, myeloperoxidase, eicosanoids, dietary fiber, intestinal mucosal protection
- MeSH terms
- Animals, Butyrates, Colitis, Colon, Diet, Enema, Hydrogen-Ion Concentration, Inulin, Male, Dextran Sulfate, Rats, Sprague-Dawley, Rats
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