The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Itraconazole oral solution and intravenous formulations: a review of pharmacokinetics and pharmacodynamics
Abstract
Itraconazole is a triazole antifungal agent with a broad spectrum of activity. It is well tolerated and highly efficacious, particularly because its main metabolite, hydroxy-itraconazole, also has considerable antifungal activity. Two new formulations of itraconazole, an oral solution and an intravenous formulation, have recently been developed, which combine lipophilic itraconazole with cyclodextrin. These formulations have improved the solubility of itraconazole, leading to enhanced absorption and bioavailability compared with the original capsule formulation, without having an impact on the tolerability profile of itraconazole. The oral solution and intravenous formulations of itraconazole produce consistent plasma concentrations and are ideal for the treatment of systemic fungal infections in a wide range of patient populations. The additional flexibility offered by the different routes of administration means that itraconazole treatment can be specifically tailored for use in all patients, including children and those requiring intensive care.
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Cites
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“Gastrointestinal side-effects may also be related to the underlying disease, concomitant medication or chemotherapy (46).”
BackgroundResultInfluentialRepeated-Dose Pharmacokinetics of an Oral Solution of Itraconazole in Infants and Children
de Repentigny, L., Ratelle, J., Leclerc, J.-M., Cornu, G., Sokal, E. M., Jacqmin, P., & de Beule, K. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.2.404 · Cited by 142 · cited 3×
“Furthermore, adjusting the dosages of capsules for children can prove troublesome (53).”
BackgroundInfluentialSafety and pharmacokinetics of fluconazole in children with neoplastic diseases
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Cited by
Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw326 · Cited by 2,926
Walsh, T. J., Anaissie, E. J., Denning, D. W., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Segal, B. H., Steinbach, W. J., Stevens, D. A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/525258 · Cited by 2,706
Nanosuspensions in drug delivery
Rabinow, B. E. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1494 · Cited by 1,524
Guidelines for Treatment of Candidiasis
Pappas, P. G., Rex, J. H., Sobel, J. D., Filler, S. G., Dismukes, W. E., Walsh, T. J., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/380796 · Cited by 1,440
Cyclodextrins in drug delivery: An updated review
Challa, R., Ahuja, A., Ali, J., & Khar, R. K. (2005) · AAPS PharmSciTech · doi:10.1208/pt060243 · Cited by 1,215
Metadata
- Authors
- Willems, L., van der Geest, R., & de Beule, K.
- Venue
- Journal of Clinical Pharmacy and Therapeutics
- Publisher
- Hindawi Limited
- Published
- 2001-06-15
- Volume
- 26
- Issue
- 3
- Pages
- 159-169
- ISSN
- 0269-4727 (ISSN-L)
- 1365-2710
- OpenAlex
- W2021321721
- Cited by
- 227
- References
- 9
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Willems, L., van der Geest, R., & de Beule, K. (2001). Itraconazole oral solution and intravenous formulations: a review of pharmacokinetics and pharmacodynamics. Journal of Clinical Pharmacy and Therapeutics. https://doi.org/10.1046/j.1365-2710.2001.00338.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
