Cyclodextrins in drug delivery: An updated review
Open accessAbstract
The purpose of this review is to discuss and summarize some of the interesting findings and applications of cyclodextrins (CDs) and their derivatives in different areas of drug delivery, particularly in protein and peptide drug delivery and gene delivery. The article highlights important CD applications in the design of various novel delivery systems like liposomes, microspheres, microcapsules, and nanoparticles. In addition to their well-known effects on drug solubility and dissolution, bioavailability, safety, and stability, their use as excipients in drug formulation are also discussed in this article. The article also focuses on various factors influencing inclusion complex formation because an understanding of the same is necessary for proper handling of these versatile materials. Some important considerations in selecting CDs in drug formulation such as their commercial availability, regulatory status, and patent status are also summarized. CDs, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems associated with the delivery of different novel drugs through different delivery routes.
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CD has been previously reported to deplete cholesterol from cell membranes.
“as CD has been previously reported to deplete cholesterol from cell membranes [71, 72].”
From The Effect of Lycopene Preexposure on UV‐B‐Irradiated Human Keratinocytes (2016) · cites this paper as [71]
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Approaches for enhancing oral bioavailability of peptides and proteins
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Cyclodextrin based novel drug delivery systems
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Courtois, J. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.04.007 · Cited by 176 · see citing works
The Effect of Lycopene Preexposure on UV‐B‐Irradiated Human Keratinocytes
Ascenso, A., Pedrosa, T., Pinho, S., Pinho, F., Oliveira, J. M. P. F. D., Cabral Marques, H., Oliveira, H., Simões, S., & Santos, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8214631 · Cited by 57 · see citing works
- Authors
- Challa, R., Ahuja, A., Ali, J., & Khar, R. K.
- Affiliations
- Jamia Hamdard (IN)
- Corresponding author
- Ahuja, Alka
- Venue
- AAPS PharmSciTech
- Published
- 2005-06
- Volume
- 6
- Issue
- 2
- Pages
- E329-E357
- ISSN
- 1530-9932 (ISSN-L)
- PMC
- PMC2750546
- OpenAlex
- W2073394985
- Cited by
- 1,215
- References
- 227
- Citations by year
- 2026: 22 · 2025: 36 · 2024: 53 · 2023: 62 · 2022: 61 · 2021: 68 · 2020: 74 · 2019: 77 · 2018: 78 · 2017: 70 · 2016: 74 · 2015: 74 · 2014: 68 · 2013: 61 · 2012: 63
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- cyclodextrins, cyclodextrin derivatives, drug delivery, protein drug delivery, peptide delivery, gene delivery, liposomes, microspheres, microcapsules, nanoparticles, drug solubility, bioavailability, drug stability, pharmaceutical excipients, inclusion complexation, drug formulation
- MeSH terms
- Animals, Cyclodextrins, Humans, Permeability, Skin, Drug Delivery Systems
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