Cited by 204Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

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Modified LDL – trigger of atherosclerosis and inflammation in the arterial intima

Pentikäinen, M. O., Öörni, K., Ala‐Korpela, M., Kovanen, P. T.·2000·Journal of Internal Medicine

DOI 10.1046/j.1365-2796.2000.00655.x

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Abstract

Abstract. Pentikäinen MO, Öörni K, Ala‐Korpela M, Kovanen PT (Wihuri Research Institute, Helsinki, Finland). Modified LDL – trigger of atherosclerosis and inflammation in the arterial intima (Minisymposium). J Intern Med 2000; 247: 359–370. Atherosclerosis is characterized by chronic inflammation of an injured intima. The pathological processes are initiated by accumulation of morphologically distinct, modified forms of LDL, and followed by cellular infiltration and foam cell formation. Activated intimal cells secrete enzymes and agents capable of modifying LDL, and the modified lipids of LDL, in turn, are able to activate intimal cells and to trigger various inflammatory signals. These processes can initiate and maintain a vicious circle in the intima and lead to lesion progression. In this review, we focus on the LDL modifications relevant to the initial lipid accumulation and discuss their pro‐inflammatory effects.

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Authors: Pentikäinen, M. O., Öörni, K., Ala‐Korpela, M., & Kovanen, P. T.
Affiliations: Wihuri Research Institute (FI)
Corresponding author: Kovanen, P. T.
ORCID: Pentikäinen, M. O.
Öörni, K.
Ala‐Korpela, M.
Kovanen, P. T.
Venue: Journal of Internal Medicine
Publisher: Wiley
Published: 2000-03
Volume: 247
Issue: 3
Pages: 359-370
ISSN: 0954-6820 (ISSN-L)
1365-2796
DOI: 10.1046/j.1365-2796.2000.00655.x
OpenAlex: W2021937355
Cited by: 204
References: 103
Citations by year: 2026: 1 · 2025: 9 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 9 · 2020: 11 · 2019: 17 · 2018: 7 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 10
FWCI: 1.01
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 664 d)
Locations: Journal of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: modified LDL, atherosclerosis, arterial intima, inflammation, foam cell formation, lipid accumulation, pro-inflammatory effects, lesion progression
MeSH terms: Arteriosclerosis, Humans, Inflammation, Cholesterol, LDL, Tunica Intima

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Modified LDL – trigger of atherosclerosis and inflammation in the arterial intima

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