The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Modified LDL – trigger of atherosclerosis and inflammation in the arterial intima
Abstract
Abstract. Pentikäinen MO, Öörni K, Ala‐Korpela M, Kovanen PT (Wihuri Research Institute, Helsinki, Finland). Modified LDL – trigger of atherosclerosis and inflammation in the arterial intima (Minisymposium). J Intern Med 2000; 247: 359–370. Atherosclerosis is characterized by chronic inflammation of an injured intima. The pathological processes are initiated by accumulation of morphologically distinct, modified forms of LDL, and followed by cellular infiltration and foam cell formation. Activated intimal cells secrete enzymes and agents capable of modifying LDL, and the modified lipids of LDL, in turn, are able to activate intimal cells and to trigger various inflammatory signals. These processes can initiate and maintain a vicious circle in the intima and lead to lesion progression. In this review, we focus on the LDL modifications relevant to the initial lipid accumulation and discuss their pro‐inflammatory effects.
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“Extracellular modifications of the infiltrated plasma lipoproteins initiate the local innate and adaptive immune responses in the intima16.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [16]
Citations
Cites
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Research works printed but not linked: 1
- Virchow R., 1856, Gesammelte Abhandlungen Zur Wissenschaftlichen Medizin, 458
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Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341
Self-citationThe immunology of atherosclerosis
Gisterå, A., & Hansson, G. K. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.51 · Cited by 982
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Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics
Li, Z.-M., Xu, S., & Liu, P. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.193 · Cited by 567
Inflammation in atherosclerosis: pathophysiology and mechanisms
Ajoolabady, A., Praticò, D., Lin, L., Mantzoros, C. S., Bahijri, S., Tuomilehto, J. O., & Ren, J. T. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07166-8 · Cited by 532
Metadata
- Authors
- Pentikäinen, M. O., Öörni, K., Ala‐Korpela, M., & Kovanen, P. T.
- Affiliations
- Wihuri Research Institute (FI)
- Corresponding author
- Kovanen, P. T.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2000-03
- Volume
- 247
- Issue
- 3
- Pages
- 359-370
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2021937355
- Cited by
- 204
- References
- 103
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 9 · 2020: 11 · 2019: 17 · 2018: 7 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 10
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- modified LDL, atherosclerosis, arterial intima, inflammation, foam cell formation, lipid accumulation, pro-inflammatory effects, lesion progression
- MeSH terms
- Arteriosclerosis, Humans, Inflammation, Cholesterol, LDL, Tunica Intima
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