Heart failure in the general population of men - morbidity, risk factors and prognosis
Open accessAbstract
AIMS: To analyse the prevalence, aetiology and prognosis of heart failure. METHODS AND RESULTS: A random population sample of men (n=7495) was examined at baseline in 1970-73 and followed until 1996. During up to 27 years, 937 men were hospitalized for heart failure. For the statistical analysis, odds ratios and 95% confidence intervals, multivariate logistic regression and time-dependent Cox analysis were used. The incidence rate was 2.1, 9.1 and 11.5 per 1000 person-years in the age groups 55-64, 65-74 and 75-79, and the prevalences were 0.6, 2.8 and 6.2%, respectively. Valvular heart disease was the aetiology in 5.8%, coronary heart disease only or in combination with hypertension in 58.8%, and hypertension only in 20.3%, and various combinations with diabetes in 4.5%. Of the remaining 12.1%, 96% were smokers and 64% were registered for alcohol abuse. Risk factors were increasing age, myocardial infarction in the family, diabetes mellitus, chest pain, tobacco smoking, high coffee consumption, alcohol abuse, high body mass index, high blood pressure as well as treatment for hypertension, but not high total cholesterol or psychological stress. Mortality after the diagnosis was increased eight times. CONCLUSIONS: Coronary heart disease and hypertension were the most common concomitant diseases. Risk factors were similar to those in coronary heart disease, and also alcohol abuse, but not high total cholesterol, low physical activity or psychological stress. Mortality was high.
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In human studies, conclusions are not firm regarding the direct role of obesity in the development of heart failure.
“However, in human studies, we mainly have to rely on cross-sectional data at this time, and the conclusions are not firm regarding the direct role of obesity in the development of heart failure (14, 46, 132, 376).”
From Cardiac remodeling in obesity (2008) · cites this paper as [376]
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Self-citation
- Authors
- Wilhelmsen, L., Rosengren, A., Eriksson, H., & Lappas, G.
- Affiliations
- University of Gothenburg (SE)
- ORCID
- Rosengren, A.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2001-03-06
- Volume
- 249
- Issue
- 3
- Pages
- 253-261
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2013147647
- Cited by
- 315
- References
- 35
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 9 · 2022: 12 · 2021: 19 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 16 · 2016: 15 · 2015: 15 · 2014: 9 · 2013: 15 · 2012: 14
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hjärt-Lungfonden
- Vetenskapsrådet
- Medical Research Council
- Socialstyrelsen
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- heart failure, men, heart failure incidence, heart failure prevalence, risk factors, prognosis, mortality, coronary artery disease, hypertension, valvular heart disease, diabetes mellitus, alcohol abuse, smoking, body mass index, family history of myocardial infarction, etiology
- MeSH terms
- Alcohol Drinking, Coronary Disease, Heart Failure, Hospitalization, Humans, Hypertension, Male, Middle Aged, Morbidity, Prognosis, Risk Factors, Prevalence, Logistic Models
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