The DOI matches its Crossref record; 31 of the 33 references it cites were found in a registry or an index.
Localization of Vasopressin (V1a) Receptor Binding and mRNA in the Rhesus Monkey Brain
Abstract
Centrally released arginine vasopressin (AVP) has been associated with various behavioural and cognitive effects, such as scent marking, aggression, and memory, which are believed to be mediated by the V 1a subtype of the vasopressin receptor. Although the distribution of V 1a receptors is conserved in a few brain regions, the pattern of expression of this receptor is, in general, highly species‐specific. We have used receptor autoradiography with the linear V 1a receptor ligand (125 I‐Phenylacetyl‐D‐Tyr(Me)‐Phe‐Gln‐Asn‐Arg‐Pro‐Arg‐Tyr‐NH 2) to characterize the pattern of receptor binding in the rhesus monkey brain. Brain sites of V 1a receptor synthesis were defined using in‐situ hybridization. The regions of highest V 1a receptor density included the prefrontal, cingulate, pyriform, and entorhinal cortex, as well as the presubiculum and mamillary bodies. In addition, V 1a receptor binding and mRNA were detected in several regions reported to have V 1a receptor in most rodents, including the amygdala, bed nucleus of the stria terminalis, lateral septum, hypothalamus and the brainstem. The distribution is consistent with a role for vasopressin in higher cognitive functions, especially memory, in primates.
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“Nevertheless, before these pharmacological limitations were fully understood, these radioligands (as well as the older tritiated versions of the endogenous neuropeptides themselves) were used for receptor autoradiography in three primate species: in the common marmoset for OXTR and AVPR1a (29,30), in the rhesus macaque for AVPR1a (31), and in human for OXTR and AVPR1a (32,33).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [31]
In the citing paper
“The rhesus macaque brain in general exhibits extremely sparse OXTR expression relative to AVPR1a (27,31), with the most dense OXTR binding seen in the NBM and superficial grey layer of the SC (Fig. 2c,f).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [31]
In the citing paper
“Similar to Callithrix and Callicebus, V1aR is widely distributed throughout the brain of Macaca, with notable expression in the social-decision making network as well in regions conventionally identified within social/cognitive circuits, including the CeA, PFC, CC, and IC (confirmed by in situ hybridization; Young et al., 1999).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Young et al., 1999
In the citing paper
“The limited information on sex differences in V1aR shows that male and female Macaca (Young et al., 1999) and Homo (Loup et al., 1991) display similar density and distribution of V1aR.”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Young et al., 1999
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Items 101–140 of 140
Development of a radioligand for imaging V 1a vasopressin receptors with PET
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Exposure to single prolonged stress fails to induce anxiety-like behavior in mice
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Intranasal vasopressin expedites dishonesty in women
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Vasopressin as a Possible Link between Sleep-Disturbances and Memory Problems
Török, B., Varga, J. M., & Zelena, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415467 · Cited by 6
“However, V1aR is also the dominant form in the central nervous system and is associated with various behavioral and cognitive effects [27].”
BackgroundEpigenetic Modulation of Vasopressin Expression in Health and Disease
Török, B., Fazekas, C. L., Szabó, A., & Zelena, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179415 · Cited by 7
“V1b receptors can be found primarily on the anterior lobe of the pituitary; thus, it is involved in the regulation of the stress axis [19].”
BackgroundDifede, J., McAleavey, A. A., Emrich, M., Jick, A. R., Ovalles, A., Wyka, K., Spielman, L. A., Olden, M., Peskin, M., Becket-Davenport, C., et al. (2023) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2023.101116 · Cited by 6
Efficacy and safety of V1a receptor antagonists in autism spectrum disorder: A meta‐analysis
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“Additionally, it is possible that the manipulation of these circuits contributes to the development of certain diseases like depression, anxiety and violent behaviour (Benarroch, 2013; Young et al., 1999).”
BackgroundHuang, C., Jia, Z., Tang, C., Hou, W., Li, L., Guo, X., Zhang, L., Qu, Y., Li, Y., Li, Y., et al. (2024) · Neuroendocrinology · doi:10.1159/000540938 · Cited by 6
“V1aRs are found to be distributed in the ACC of montane and prairie voles [33], Taiwan voles [34], rhesus monkeys [35] and display different levels in different species, sexes, and even individuals.”
The role of the prefrontal cortex in modulating aggression in humans and rodents
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“In addition, the modulation of these circuits may be related to the genesis of some disorders, such as depression, anxiety, and aggressive behavior [4-6].”
BackgroundThe Role of the Preoptic Area in Social Interaction in Zebrafish
Kelly, J. R. (2019) · Liverpool John Moores University · doi:10.24377/ljmu.t.00010853 · Cited by 1
“Centrally administered AVP was shown to increase affiliation in male Prairie voles but not in male Montane voles (Young et al., 1999a).”
BackgroundInfluentialA Comparative Analysis of the Neural Basis for Dorsal-Ventral Swimming in the Nudipleura
Lillvis, J. L. (2022) · Digital Archive @ GSU · doi:10.57709/3074014
Brain and Cardiovascular Diseases: Molecular Aspects
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Oxytocin, Vasopressin, and Development of Social Behavior in Primates
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Translational Medicine Strategies for Drug Development for Impulsive Aggression
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Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2026) · eLife · doi:10.1101/2024.12.09.627541 · Cited by 1
Schrock, A. E., Grossman, M. R., Grebe, N. M., Sharma, A., Freeman, S. M., Palumbo, M. C., Bales, K. L., Patisaul, H. B., & Drea, C. M. (2025) · Biology Letters · doi:10.1098/rsbl.2024.0647
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2025) · eLife · doi:10.7554/elife.105355.1
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2025) · eLife · doi:10.7554/elife.105355 · Cited by 1
“It has been reported that AVP fibers are apparent in the hindbrain, such as the parabrachial nucleus, locus coeruleus, and near inferior olive nuclei ( Young et al., 1999 ).”
Fudge, J. L., & Myers, D. C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00010-5
Yu, J., Shen, M., & He, T. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07801-2
“V1aR and V1bR are predominantly distributed within the central nervous system (e.g., cortex, hypothalamus, pons, medulla oblongata, cerebellum) [205–208], while V1 receptors (V1aR/V1bR) are widely expressed in peripheral tissues, including the vascular system, heart, lungs, kidneys, adrenal glands,…”
Gumerova, A. A., Pevnev, G., Korkmaz, F., Cheliadinova, U., Burganova, G., Vasilyeva, D., Cullen, L., Barak, O., Sultana, F., Zhou, W., et al. (2026) · eLife · doi:10.7554/elife.105355.2
New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
Martucci, L. L. (2021) · theses.fr (ABES) · doi:10.70675/027d1ae2zd2ebz4677za019ze6ccd94cafe9
Simon, N. G., Brownstein, M., Anderson, K. E., Lu, S., & Maibach, H. T. (2026) · Biomedicines · doi:10.3390/biomedicines14040889
“These effects are primarily mediated through V1aR, which is extensively expressed in the brain in non-human primates and humans [32,38,39].”
Weisenseel, Z., & Glasper, E. R. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101328
“V1aR-specific radioligand binding reveals receptor expression across a wide array of cortical and subcortical regions and several brainstem nuclei (Young et al., 1999).”
Metadata
- Authors
- Young, Toloczko, & Insel
- Affiliations
- Emory University (US)
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 1999-04
- Volume
- 11
- Issue
- 4
- Pages
- 291-297
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2085176718
- Cited by
- 139
- References
- 33
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 9 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 6
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (56897)
- National Center for Research Resources (P51RR000165)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- vasopressin, vasopressin V1a receptor, receptor mRNA expression, rhesus monkey brain, prefrontal cortex, cingulate cortex, amygdala, bed nucleus of the stria terminalis, lateral septum, hypothalamus, brainstem, memory, higher mental functions
- MeSH terms
- Amino Acid Sequence, Animals, Arginine Vasopressin, Base Sequence, Binding Sites, Brain, Female, Humans, Iodine Radioisotopes, Macaca mulatta, Male, Molecular Sequence Data, Radioligand Assay, RNA, Messenger, Sequence Homology, Nucleic Acid, Sequence Homology, Amino Acid, Receptors, Vasopressin, DNA, Complementary
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