Vasopressin/serotonin interactions in the anterior hypothalamus control aggressive behavior in golden hamsters
Open accessAbstract
Studies in several species of rodents show that arginine vasopressin (AVP) acting through a V1A receptor facilitates offensive aggression, i.e., the initiation of attacks and bites, whereas serotonin (5-HT) acting through a 5-HT1B receptor inhibits aggressive responding. One area of the CNS that seems critical for the organization of aggressive behavior is the basolateral hypothalamus, particularly the anterior hypothalamic region. The present studies examine the neuroanatomical and neurochemical interaction between AVP and 5-HT at the level of the anterior hypothalamus (AH) in the control of offensive aggression in Syrian golden hamsters. First, specific V1A and 5-HT1B binding sites in the AH are shown by in vitro receptor autoradiography. The binding for each neurotransmitter colocalizes with a dense field of immunoreactive AVP and 5-HT fibers and putative terminals. Putative 5-HT synapses on AVP neurons in the area of the AH are identified by double-staining immunocytochemistry and laser scanning confocal microscopy. These morphological data predispose a functional interaction between AVP and 5-HT at the level of the AH. When tested for offensive aggression in a resident/intruder paradigm, resident hamsters treated with fluoxetine, a selective 5-HT reuptake inhibitor, have significantly longer latencies to bite and bite fewer times than vehicle-treated controls. Conversely, AVP microinjections into the AH significantly shorten the latency to bite and increase biting attacks. The action of microinjected AVP to increase offensive aggression is blocked by the pretreatment of hamsters with fluoxetine. These data suggest that 5-HT inhibits fighting, in part, by antagonizing the aggression-promoting action of the AVP system.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In rodents, the VP system regulates aggression in hamsters in sex-specific ways.
“In rodents, sex-specific regulation of partner preference in prairie voles, social recognition in rats, social play in rats, and aggression in hamsters has been found”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Ferris et al., 1997
Vasopressin also plays a role in aggression in prairie voles and Syrian hamsters, sometimes in a sex-specific manner.
“AVP also plays a role in aggression in prairie voles and Syrian hamsters, sometimes in a sex-specific manner.”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [116]
Pharmacological studies revealed that vasopressin in the anterior hypothalamus facilitates intermale aggression both in prairie voles and hamsters, while the opposite effect was found in female hamsters.
“For example, pharmacological studies revealed that AVP in the anterior hypothalamus facilitates intermale aggression both in prairie voles and hamsters (16,43,116), while the opposite effect was found in female hamsters (117).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [116]
Cites
Linnoila, M., Virkkunen, M., Scheinin, M., Nuutila, A., Rimon, R., & Goodwin, F. K. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90344-2 · Cited by 1,308 · see citing works
Aggression in humans correlates with cerebrospinal fluid amine metabolites
Brown, G. L., Goodwin, F. K., Ballenger, J. C., Goyer, P. F., & Major, L. F. (1979) · Psychiatry Research · doi:10.1016/0165-1781(79)90053-2 · Cited by 1,133 · see citing works
Serotonergic Studies in Patients With Affective and Personality Disorders
Coccaro, E. F. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810070013002 · Cited by 1,087 · see citing works
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 2× · see citing works
“…numerous brain functions (DeWied, 1971; Cooper et al., 1979; Pittman et al., 1982; Fehm-Wolfsdorf et al., 1988; Dantzer and Bluthe, 1992), including aggression (Ferris and Potegal, 1988, Koolhaas et al., 1990, 1991; Potegal and Ferris, 1990; Winslow et al., 1993; Delville et al., 1996a,b).”
BackgroundAggression, suicide, and serotonin: relationships to CSF amine metabolites
Brown, G. L., Ebert, M. H., Goyer, P. F., Jimerson, D. C., Klein, W. J., Bunney, W. E., & Goodwin, F. K. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.6.741 · Cited by 907 · see citing works
Enhanced Aggressive Behavior in Mice Lacking 5-HT 1B Receptor
Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Ségu, L., Buhot, M.-C., & Hen, R. (1994) · Science · doi:10.1126/science.8091214 · Cited by 839 · see citing works
Long Term Effect of Vasopressin on the Maintenance of a Conditioned Avoidance Response in Rats
de Wied, D. (1971) · Nature · doi:10.1038/232058a0 · Cited by 468 · see citing works
Kruesi, M. J. P. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810170019003 · Cited by 413 · see citing works
Sawchenko, P. E., Swanson, L. W., Steinbusch, H. W. M., & Verhofstad, A. A. J. (1983) · Brain Research · doi:10.1016/0006-8993(83)90945-9 · Cited by 380 · see citing works
Mehlman, P. T., Higley, J. D., Faucher, I., Lilly, A. A., Taub, D. M., Vickers, J. H., Suomi, S. J., & Linnoila, M. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.10.1485 · Cited by 375 · see citing works
Cerebrospinal Fluid Monoamine and Adrenal Correlates of Aggression in Free-Ranging Rhesus Monkeys
Higley, J. D. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820060016002 · Cited by 329 · see citing works
Serotonin Receptors and Animal Models of Aggressive Behavior
Olivier, B., Mos, J., van Oorschot, R., & Hen, R. (1995) · Pharmacopsychiatry · doi:10.1055/s-2007-979624 · Cited by 285 · see citing works
Hoyer, D., Engel, G., & Kalkman, H. O. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90657-0 · Cited by 281 · see citing works
Vasopressin receptor blockade in the anterior hypothalamus suppresses aggression in hamsters
Ferris, C. F., & Potegal, M. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90144-8 · Cited by 259 · see citing works
Self-citationVasopressin injected into the hypothalamus triggers a stereotypic behavior in golden hamsters
Ferris, C. F., Albers, H. E., Wesolowski, S. M., Goldman, B. D., & Luman, S. E. (1984) · Science · doi:10.1126/science.6538700 · Cited by 255 · see citing works
Self-citationEvidence supporting a role for endogenous vasopressin in natural suppression of fever in the sheep.
Cooper, K., Kasting, N. W., Lederis, K. P., & Veale, W. L. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012953 · Cited by 251 · see citing works
Agranulocytosis: incidence and risk factors.
Kavoussi, R. J., LIU, J. I., & Coccaro, E. F. (1994) · PubMed · Cited by 238 · see citing works
Perry, K. W., & Fuller, R. W. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90423-m · Cited by 219 · see citing works
Self-citationTestosterone facilitates aggression by modulating vasopressin receptors in the hypothalamus
Delville, Y., Mansour, K. M., & Ferris, C. F. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02246-5 · Cited by 218 · see citing works
Self-citationLow brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence.
Virkkunen, M., Goldman, D. A., Nielsen, D. A., & Linnoila, M. (1995) · PubMed Central · Cited by 211 · see citing works
Noradrenaline and acetylcholine responses of supraoptic neurosecretory cells
Barker, J. L., Crayton, J. W., & Nicoll, R. A. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009602 · Cited by 188 · see citing works
Auerbach, S. B., Minzenberg, M., & Wilkinson, L. O. (1989) · Brain Research · doi:10.1016/0006-8993(89)90776-2 · Cited by 182 · see citing works
Microelectrophoresis of cholinergic and aminergic drugs on paraventricular neurons
Moss, R., Urban, I. J. A., & Cross, B. A. (1972) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1972.223.2.310 · Cited by 177 · see citing works
Vasopressin and serotonin interactions in the control of agonistic behavior
Ferris, C. F., & Delville, Y. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90043-4 · Cited by 172 · see citing works
Self-citationBlunted Prolactin Responses to d-Fenfluramine in Sociopathy
O’Keane, V., Moloney, E., O’Neill, H., O'connor, A., SMITH, C. E., & Dinan, T. G. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.160.5.643 · Cited by 171 · see citing works
Vasopressin excites hippocampal neurones
Mühlethaler, M., Dreifuss, J. J., & Gähwiler, B. H. (1982) · Nature · doi:10.1038/296749a0 · Cited by 162 · see citing works
5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra
Bouhelal, R., Smounya, L., & Bockaert, J. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90799-6 · Cited by 162 · see citing works
Scent Marking by Male Golden Hamsters (Mesocricetus auratus)
Johnston, R. E. (2010) · Zeitschrift für Tierpsychologie · doi:10.1111/j.1439-0310.1975.tb01128.x · Cited by 153 · see citing works
Function of a light response rhythm in hamsters
DeCoursey, P. J. (1964) · Journal of Cellular and Comparative Physiology · doi:10.1002/jcp.1030630208 · Cited by 152 · see citing works
Delville, Y. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02166-3 · Cited by 149 · see citing works
Self-citationSijbesma, H., Schipper, J., de Kloet, E. R., Mos, J., van Aken, H. H. M., & Olivier, B. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90305-l · Cited by 135 · see citing works
Medial amygdala and aggressive behavior: Interaction between testosterone and vasopressin
Koolhaas, J. M., Brink, T. H. C. V. D., Roozendaal, B., & Boorsma, F. (1990) · Aggressive Behavior · doi:10.1002/1098-2337(1990)16:3/4 · Cited by 134 · see citing works
Light-dark rhythms in hamster eating, drinking and locomotor behaviors☆
ZUCKER, I., & Stephan, F. K. (1973) · Physiology & Behavior · doi:10.1016/0031-9384(73)90356-9 · Cited by 128 · see citing works
Serotonergic modulation of social interactions in isolated male mice
Olivier, B., Mos, J., van der Heyden, J., & Hartog, J. (1989) · Psychopharmacology · doi:10.1007/bf00442239 · Cited by 126 · see citing works
Yodyingyuad, U., de la Riva, C., Abbott, D. H., Herbert, J., & Keverne, E. B. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90099-5 · Cited by 119 · see citing works
Ferris, C. F., Axelson, J. F., Martin, A., & Roberge, L. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90140-1 · Cited by 116 · see citing works
Self-citationA V1-like receptor mediates vasopressin-induced flank marking behavior in hamster hypothalamus
Albers, H., Pollock, J., Simmons, W., & Ferris, C. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-07-02085.1986 · Cited by 112 · see citing works
Self-citation5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity
Schoeffter, P., & Hoyer, D. (1989) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00168512 · Cited by 98 · see citing works
Fluoxetine Treatment of Impulsive Aggression in DSM-III-R
Coccaro, E. F., Astill, J. L., Herbert, J. L., & SCHUT, A. G. (1990) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199010000-00021 · Cited by 97 · see citing works
Sánchez, C., & Hyttel, J. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)00470-6 · Cited by 97 · see citing works
A vasopressin antagonist can reverse dominant/subordinate behavior in hamsters
Ferris, C. F., Meenan, D. M., Axelson, J. F., & Albers, H. E. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90143-5 · Cited by 94 · see citing works
Self-citationMcMillen, B. A., Scott, S. M., Williams, H. L., et al. (1987) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00165563 · Cited by 86 · see citing works
Ferris, C. F., Pollock, J. S., Albers, H. E., & Leeman, S. E. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90027-8 · Cited by 86 · see citing works
Self-citationVergnes, M., Depaulis, A., Boehrer, A., & Kempf, E. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90055-1 · Cited by 81 · see citing works
GREEN, D. J., & Gillette, R. (1983) · Nature · doi:10.1038/306784a0 · Cited by 81 · see citing works
Vasopressin generates a persistent voltage-dependent sodium current in a mammalian motoneuron
Raggenbass, M., Goumaz, M., Sermasi, E., Tribollet, E., & Dreifuss, J. J. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-06-01609.1991 · Cited by 76 · see citing works
Role of Vasopressin in Aggressive and Dominant/Subordinate Behaviors
Ferris, C. F. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34357.x · Cited by 75 · see citing works
Self-citationInhibition of vasopressin-stimulated flank marking behavior by V1-receptor antagonists
Ferris, C. F., Singer, E. A., Meenan, D. M., & Elliott Albers, H. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90092-1 · Cited by 74 · see citing works
Self-citationPotegal, M., & Ferris, C. F. (1989) · Aggressive Behavior · doi:10.1002/ab.2480150406 · Cited by 69 · see citing works
Self-citationFehm-Wolfsdorf, G., Bachholz, G., Born, J., Voigt, K., & Fehm, H. L. (1988) · Psychopharmacology · doi:10.1007/bf00212844 · Cited by 67 · see citing works
Giles, H., Lansdell, S. J., Bolofo, M. L., et al. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb16705.x · Cited by 65 · see citing works
Fluoxetine increases the extracellular levels of serotonin in the nucleus accumbens
Guan, X., & McBride, W. J. H. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90118-9 · Cited by 65 · see citing works
Ferris, C. F., Delville, Y., Grzonka, Z., Luber‐Narod, J., & Insel, T. R. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90085-t · Cited by 61 · see citing works
Self-citationRaggenbass, M., Tribollet, E., Dubois‐Dauphin, M., & Dreifuss, J. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-11-03929.1989 · Cited by 61 · see citing works
Serotonin Diminishes Aggression by Suppressing the Activity of the Vasopressin System
Ferris, C. F. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32513.x · Cited by 60 · see citing works
Self-citationNeurotransmitter Correlates of Impulsive Aggression in Humans
Coccaro, E. F. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb32511.x · Cited by 58 · see citing works
Direct excitatory action of vasopressin in the lateral septum of the rat brain
Raggenbass, M., Dubois‐Dauphin, M., Tribollet, E., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)90286-7 · Cited by 57 · see citing works
Vasopressin involvement in antipyresis, social communication, and social recognition: a synthesis.
Dantzer, R., & Bluthé, R.-M. (1992) · PubMed · Cited by 55 · see citing works
Aggression and brain serotonergic responsivity: Response to slides in male macaques
Kyes, R. C., Botchin, M. B., Kaplan, J. R., et al. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00219-u · Cited by 51 · see citing works
Liou, S. Y., & Albers, H. E. (1989) · Brain Research · doi:10.1016/0006-8993(89)91424-8 · Cited by 51 · see citing works
Ferris, C. F., Meenan, D. M., & Albers, H. E. (2008) · Neuroendocrinology · doi:10.1159/000124631 · Cited by 48 · see citing works
Self-citationGrzonka, Z., Lammek, B., Kasprzykowski, F., Gazis, D., & Schwartz, I. L. (1983) · Journal of Medicinal Chemistry · doi:10.1021/jm00358a018 · Cited by 46 · see citing works
Monoamine neurotoxins: Selective and delayed effects on behavior in colonies of laboratory rats
Ellison, G. D. (1976) · Brain Research · doi:10.1016/0006-8993(76)90688-0 · Cited by 42 · see citing works
Vasopressin-mediated slow EPSPs in a mammalian sympathetic ganglion
Peters, S., & Kreulen, D. L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90630-4 · Cited by 41 · see citing works
Central neurohypophyseal peptide pathways: Interactions with endocrine and other autonomic functions
Pittman, Q. J., Veale, W. L., & Lederis, K. P. (1982) · Peptides · doi:10.1016/0196-9781(82)90118-8 · Cited by 40 · see citing works
Murphy, T. J., & Bylund, D. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23429-2 · Cited by 38 · see citing works
Ferris, C. F., Irvin, R. W., Potegal, M., & Axelson, J. F. (1990) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1990.tb00841.x · Cited by 36 · see citing works
Self-citationFerris, C. F., Pilapil, C., Hayden‐Hixson, D. M., Wiley, R. G., & Koh, E. T. (1992) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1992.tb00159.x · Cited by 33 · see citing works
Self-citationAnti‐aggressive Effect of Zimelidine in Isolated Mice
Ögren, S. O., Holm, A. C., Rényi, A. L., & Ross, S. B. (1980) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1980.tb02028.x · Cited by 32 · see citing works
Sijbesma, H., Schipper, J., & de Kloet, E. R. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90008-t · Cited by 31 · see citing works
Serenics, serotonin and aggression.
Olivier, B., & Mos, J. (1990) · PubMed · Cited by 30 · see citing works
Postnatal development of the vasopressinergic system in golden hamsters
Delville, Y., Mansour, K. M., Quan, E. W., Yules, B., & Ferris, C. F. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90309-3 · Cited by 23 · see citing works
Self-citationHaug, M., Wallian, L., & Brain, P. F. (1990) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(90)90443-p · Cited by 21 · see citing works
Carette, B., & Poulain, P. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90008-7 · Cited by 20 · see citing works
5-Hydroxytryptamine 5-HT1B receptors inhibiting cyclic AMP accumulation in rat renal mesangial cells
Schoeffter, P., Pfeilschifter, J. M., & Bobirnac, I. (1995) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00169061 · Cited by 15 · see citing works
Antifungal Activity of D0870 against Murine Infections and Its Mechanism of Action
Yamada, H., Tsuda, T., Watanabe, T., et al. (1998) · Chemotherapy · doi:10.1159/000007102 · Cited by 3 · see citing works
Capacitance responses and fluid exchange in the cat liver.
Cv, G., Lautt, W. W., & Rd, S. (1969) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neurobiology of Aggression and Violence
Siever, L. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07111774 · Cited by 984 · see citing works
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“Specifically, V1aR antagonist injection into the AH decreased intermale aggression, while VP increased intermale aggression (Ferris et al., 1997; Caldwell and Albers, 2004a).”
BackgroundVasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504 · see citing works
Young, L. J., Nilsen, R., Waymire, K. G., MacGregor, G. R., & Insel, T. R. (1999) · Nature · doi:10.1038/23475 · Cited by 488 · see citing works
Bos, P. A., Panksepp, J., Bluthé, R.-M., & Honk, J. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.01.002 · Cited by 429 · see citing works
Central vasopressin and oxytocin release: regulation of complex social behaviours
VEENEMA, A., & NEUMANN, I. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00422-6 · Cited by 338 · see citing works
Albers, H. E. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.007 · Cited by 288 · see citing works
Song, Z., & Albers, H. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.004 · Cited by 244 · see citing works
Sankoorikal, G. M. V., Kaercher, K. A., Boon, C. J., Lee, J. K., & Brodkin, E. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.026 · Cited by 231 · see citing works
Nonapeptides and the evolutionary patterning of sociality
GOODSON, J. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00401-9 · Cited by 228 · see citing works
Oxytocin and vasopressin: powerful regulators of social behavior
Caldwell, H. K. (2017) · The Neuroscientist · doi:10.1177/1073858417708284 · Cited by 216 · see citing works
Genetics of human aggressive behaviour
Craig, I. W., & Halton, K. E. (2009) · Human Genetics · doi:10.1007/s00439-009-0695-9 · Cited by 213 · see citing works
Oxytocin and Vasopressin Receptors and Species-Typical Social Behaviors
Young, L. J. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1548 · Cited by 211 · see citing works
Albers, H. E. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.07.001 · Cited by 200 · see citing works
Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191 · see citing works
Parker, K. J., Oztan, O., Libove, R. A., Mohsin, N., Karhson, D. S., Sumiyoshi, R. D., Summers, J. E., Hinman, K. E., Motonaga, K. S., Phillips, J. M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau7356 · Cited by 185 · see citing works
Genetic determinants of aggression and impulsivity in humans
Pavlov, K. A., Chistiakov, D. A., & Chekhonin, V. P. (2012) · Journal of Applied Genetics · doi:10.1007/s13353-011-0069-6 · Cited by 184 · see citing works
The neurobiological basis of human aggression: A review on genetic and epigenetic mechanisms
Waltes, R., Chiocchetti, A. G., & Freitag, C. M. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32388 · Cited by 182 · see citing works
Veenema, A. H., Beiderbeck, D. I., Lukas, M., & Neumann, I. D. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.006 · Cited by 180 · see citing works
Gobrogge, K. L., Liu, Y., Jia, X., & Wang, Z. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21364 · Cited by 178 · see citing works
Gobrogge, K. L., Liu, Y., Young, L. J., & Wang, Z. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908620106 · Cited by 178 · see citing works
A genome‐wide approach to children's aggressive behavior: <i>The EAGLE consortium</i>
Pappa, I., St Pourcain, B., Benke, K., Cavadino, A., Hakulinen, C., Nivard, M. G., Nolte, I. M., Tiesler, C. M. T., Bakermans‐Kranenburg, M. J., Davies, G. E., et al. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32333 · Cited by 195 · see citing works
Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors
Suri, D., Teixeira, C. M., Cagliostro, M. K. C., Mahadevia, D., & Ansorge, M. S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.231 · Cited by 167 · see citing works
Anatomy and neurochemistry of the pair bond
Young, L. J., Murphy Young, A. Z., & Hammock, E. A. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20771 · Cited by 163 · see citing works
Evolving nonapeptide mechanisms of gregariousness and social diversity in birds
Goodson, J. L., Kelly, A. M., & Kingsbury, M. A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.005 · Cited by 139 · see citing works
Beiderbeck, D. I., Neumann, I. D., & Veenema, A. H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05974.x · Cited by 142 · see citing works
Localization of Vasopressin (V<sub>1a</sub>) Receptor Binding and mRNA in the Rhesus Monkey Brain
Young, Toloczko, & Insel (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00332.x · Cited by 139 · see citing works
Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129 · see citing works
Rood, B. D., Stott, R. T., You, S., Smith, C. J. W., Woodbury, M. E., & De Vries, G. J. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23288 · Cited by 120 · see citing works
Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction
Shin, S., Pribiag, H., Lilascharoen, V., Knowland, D., Wang, X.-Y., & Lim, B. K. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.040 · Cited by 120 · see citing works
Phelps, S. M., & Young, L. J. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10902 · Cited by 116 · see citing works
Oxytocin and vasopressin: genetics and behavioral implications
Caldwell, H. K., & Young, W. S. (2006) · Handbook of Neurochemistry and Molecular Neurobiology · doi:10.1007/978-0-387-30381-9_25 · Cited by 113 · see citing works
Effect of photoperiod on vasopressin-induced aggression in Syrian hamsters
Caldwell, H. K., & Albers, H. E. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.04.006 · Cited by 97 · see citing works
Sakata, J. T., Coomber, P., Gonzalez-Lima, F., & Crews, D. (2000) · Brain Behavior and Evolution · doi:10.1159/000006648 · Cited by 96 · see citing works
Gutzler, S. J., Karom, M., Erwin, W. D., & Albers, H. E. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07190.x · Cited by 86 · see citing works
Sex differences in the regulation of offensive aggression and dominance by arginine-vasopressin
Terranova, J. I., Ferris, C. F., & Albers, H. E. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00308 · Cited by 85 · see citing works
Self-citationRole of V1a vasopressin receptors in the control of aggression in Syrian hamsters
Elliott Albers, H., Dean, A., Karom, M. C., Smith, D., & Huhman, K. L. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.081 · Cited by 78 · see citing works
Ho, J. M., Murray, J. H., Demas, G. E., & Goodson, J. L. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.021 · Cited by 76 · see citing works
DiBenedictis, B. T., Nussbaum, E. R., Cheung, H. K., & Veenema, A. H. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24216 · Cited by 74 · see citing works
“…the extensive body of work showing that AVP signaling in the AH facilitates intermale aggression in diverse adult rodent species (Albers et al., 2006; Caldwell & Albers, 2004; Cooper, Karom, Huhman, & Albers, 2005; Gobrogge, Liu, Young, & Wang, 2009; Ferris et al., 1997; Potegal & Ferris, 1989).”
BackgroundOPHIR, A., CAMPBELL, P., HANNA, K., & PHELPS, S. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.07.009 · Cited by 66 · see citing works
Goodson, J. L., Kabelik, D., & Schrock, S. E. (2009) · Biology Letters · doi:10.1098/rsbl.2009.0316 · Cited by 65 · see citing works
Caldwell, H. K. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-1704-0_12 · Cited by 58 · see citing works
Smith, C. J. W., DiBenedictis, B. T., & Veenema, A. H. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.001 · Cited by 59 · see citing works
Masugi-Tokita, M., Flor, P. J., & Kawata, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.198 · Cited by 35 · see citing works
Taylor, J. H., Walton, J. C., McCann, K. E., Norvelle, A., Liu, Q., Vander Velden, J. W., Borland, J. M., Hart, M., Jin, C., Huhman, K. L., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121037119 · Cited by 35 · see citing works
Rogers Flattery, C. N., Coppeto, D. J., Inoue, K., Rilling, J. K., Preuss, T. M., & Young, L. J. (2022) · Brain Structure and Function · doi:10.1007/s00429-021-02369-7 · Cited by 31 · see citing works
- Authors
- Ferris, C. F., Melloni Jr, R. H., Koppel, G., Perry, K. W., Fuller, R. W., & Delville, Y.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Eli Lilly (United States) (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-06-01
- Volume
- 17
- Issue
- 11
- Pages
- 4331-4340
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6573530
- OpenAlex
- W2157677118
- Cited by
- 495
- References
- 77
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 15 · 2021: 7 · 2020: 18 · 2019: 19 · 2018: 10 · 2017: 18 · 2016: 14 · 2015: 28 · 2014: 23 · 2013: 21 · 2012: 26
- FWCI
- 22.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH052280, MH52280)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, serotonin, anterior hypothalamus, offensive aggression, V1a receptor, 5-HT1B receptor, receptor binding sites, resident-intruder paradigm, fluoxetine, golden hamster, serotonin reuptake inhibition
- MeSH terms
- Aggression, Animals, Arginine Vasopressin, Behavior, Animal, Fluoxetine, Cricetinae, Hypothalamus, Anterior, Male, Mesocricetus, Microinjections, Receptors, Serotonin, Serotonin, Vasoconstrictor Agents, Selective Serotonin Reuptake Inhibitors, Receptors, Vasopressin, Receptor, Serotonin, 5-HT1B
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review