Cited by 495Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Vasopressin/serotonin interactions in the anterior hypothalamus control aggressive behavior in golden hamsters

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Ferris, Craig F., Melloni Jr, Richard H., Koppel, Gary, Perry, Kenneth W., Fuller, Ray W., Delville, Yvon·1997·The Journal of Neuroscience

Abstract

Studies in several species of rodents show that arginine vasopressin (AVP) acting through a V1A receptor facilitates offensive aggression, i.e., the initiation of attacks and bites, whereas serotonin (5-HT) acting through a 5-HT1B receptor inhibits aggressive responding. One area of the CNS that seems critical for the organization of aggressive behavior is the basolateral hypothalamus, particularly the anterior hypothalamic region. The present studies examine the neuroanatomical and neurochemical interaction between AVP and 5-HT at the level of the anterior hypothalamus (AH) in the control of offensive aggression in Syrian golden hamsters. First, specific V1A and 5-HT1B binding sites in the AH are shown by in vitro receptor autoradiography. The binding for each neurotransmitter colocalizes with a dense field of immunoreactive AVP and 5-HT fibers and putative terminals. Putative 5-HT synapses on AVP neurons in the area of the AH are identified by double-staining immunocytochemistry and laser scanning confocal microscopy. These morphological data predispose a functional interaction between AVP and 5-HT at the level of the AH. When tested for offensive aggression in a resident/intruder paradigm, resident hamsters treated with fluoxetine, a selective 5-HT reuptake inhibitor, have significantly longer latencies to bite and bite fewer times than vehicle-treated controls. Conversely, AVP microinjections into the AH significantly shorten the latency to bite and increase biting attacks. The action of microinjected AVP to increase offensive aggression is blocked by the pretreatment of hamsters with fluoxetine. These data suggest that 5-HT inhibits fighting, in part, by antagonizing the aggression-promoting action of the AVP system.

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Crossref · 10.1523/jneurosci.17-11-04331.1997

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Authors
Ferris, C. F., Melloni Jr, R. H., Koppel, G., Perry, K. W., Fuller, R. W., & Delville, Y.
Affiliations
  • University of Massachusetts Chan Medical School (US)
  • Eli Lilly (United States) (US)
Venue
The Journal of Neuroscience
Published
1997-06-01
Volume
17
Issue
11
Pages
4331-4340
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2157677118
Cited by
495
References
77
Citations by year
2026: 5 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 15 · 2021: 7 · 2020: 18 · 2019: 19 · 2018: 10 · 2017: 18 · 2016: 14 · 2015: 28 · 2014: 23 · 2013: 21 · 2012: 26
FWCI
22.73
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders
National Institute of Mental Health (R01MH052280, MH52280)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
vasopressin, serotonin, anterior hypothalamus, offensive aggression, V1a receptor, 5-HT1B receptor, receptor binding sites, resident-intruder paradigm, fluoxetine, golden hamster, serotonin reuptake inhibition
MeSH terms
Aggression, Animals, Arginine Vasopressin, Behavior, Animal, Fluoxetine, Cricetinae, Hypothalamus, Anterior, Male, Mesocricetus, Microinjections, Receptors, Serotonin, Serotonin, Vasoconstrictor Agents, Selective Serotonin Reuptake Inhibitors, Receptors, Vasopressin, Receptor, Serotonin, 5-HT1B

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