Patterns of brain vasopressin receptor distribution associated with social organization in microtine rodents
Open accessAbstract
Central vasopressin pathways have been implicated in the mediation of paternal behavior, selective aggression, and affiliation in monogamous prairie voles. Here we demonstrate markedly different patterns of brain vasopressin receptor binding in the monogamous prairie vole and the congeneric nonmonogamous (promiscuous) montane vole. Vasopressin binding was assessed with both 3H-vasopressin and 125I-sarc-AVP using receptor autoradiography. The specificity of binding was consistent with a V1a receptor, the saturation kinetics were similar in the two species, and neither species showed evidence of sexual dimorphisms. In the prairie vole, highest specific binding was observed in the accessory olfactory bulb, diagonal band, laterodorsal thalamus, and superior colliculus. In the montane vole, specific binding was observed in the accessory olfactory bulb and superior colliculus as well, but in several other regions with high levels of binding in the prairie vole, binding was low or undetectable in the montane vole. In this nonmonogamous species, specific binding was high in lateral septum. Functional studies demonstrated the induction of phosphoinositol by AVP in the septum of the montane vole but not in the prairie vole. The pattern of 125I-sarc-AVP binding to lateral septum may reflect the social organization of these two species, as similar differences in AVP receptor distribution in the lateral septum were also observed in two related species, pine voles and meadow voles, which are monogamous and nonmonogamous, respectively. These results, along with earlier studies of AVP's effects on pair bonding, suggest the importance of this neuropeptide for the mediation of behaviors related to social organization.
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Oxytocin and vasopressin buttress many areas of interpersonal interaction: managing social stress, fostering emotion recognition and memory for social information.
“These hormones buttress many areas of interpersonal interaction: managing social stress, fostering emotion recognition and memory for social information, and so on (Meyer-Lindenberg et al. 2011; Insel et al. 1994; Heinrichs et al. 2009).”
From Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships (2012) · cites this paper as Insel et al. 1994
The paper’s introductory discussion (page not supplied) reports that vasopressin facilitates social memory in rats and alters squirrel monkeys’ behavioral response to social separation; it also reports that oxytocin facilitates selective affiliation in female prairie voles. It does not establish that these hormones manage social stress or foster emotion recognition. The cited evidence is chiefly about animal social behavior, not the full range of interpersonal functions claimed. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIn male meadow voles, V1aR density in the VP is significantly lower than in prairie voles.
“In male meadow voles, V1aR density in the VP is significantly lower than in prairie voles (Insel et al 1994; Young et al 1997).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Insel et al 1994
There are striking species differences in the location and density of AVP and OT receptors.
“Although there are few species differences in the distribution of AVP and OT in the brain [10, 11], there are striking species differences in the location and density of their respective receptors [7, 8].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [8]
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- Authors
- Insel, T., Wang, Z., & Ferris, C.
- Affiliations
- National Institute of Mental Health (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1994-09-01
- Volume
- 14
- Issue
- 9
- Pages
- 5381-5392
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6577077
- OpenAlex
- W1917460858
- Cited by
- 454
- References
- 38
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 7 · 2023: 7 · 2022: 31 · 2021: 16 · 2020: 10 · 2019: 10 · 2018: 16 · 2017: 26 · 2016: 11 · 2015: 13 · 2014: 17 · 2013: 28 · 2012: 23
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- vasopressin, V1a receptor, Microtus ochrogaster, montane vole, microtine rodents, social organization, monogamy, pair bonding, lateral septum, accessory olfactory bulb, superior colliculus, diagonal band, phosphoinositide signaling, promiscuity
- MeSH terms
- Animals, Arginine Vasopressin, Brain, Arvicolinae, Female, Hydrolysis, Male, Phosphatidylinositols, Social Environment, Tissue Distribution, Receptors, Vasopressin
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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