Cited by 113Stress Responses and CortisolNeuroendocrine regulation and behaviorMemory and Neural Mechanisms

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Differential Expression of c‐fos mRNA Within Neurocircuits of Male Hamsters Exposed to Acute or Chronic Defeat

Kollack‐Walker, Don, Watson, Akil·1999·Journal of Neuroendocrinology

DOI 10.1046/j.1365-2826.1999.00354.x

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Abstract

Chronic exposure to stress has been implicated in physical and mental illness, and such experiences can produce alterations in the connectivity and number of neurones within the brain to variations in the expression of specific genes. The purpose of this study was to determine how repeated exposure to social defeat affects neuronal activation patterns within the male Syrian hamster brain. Toward this end, the levels c-fos mRNA were compared among three groups: (1) handled controls (HC); (2) acutely defeated males (AD); and (3) chronically defeated males (15 min aggression daily, 7 days) exposed to an acute challenge (CD). Plasma glucocorticoids were also measured and compared among groups as an index of neuroendocrine activity. The results show a selective pattern of habituation of immediate early gene expression within the brains of chronically defeated males. In particular, c-fos mRNA levels were significantly decreased within the paraventricular nucleus of the hypothalamus (PVN), supraoptic nucleus of the hypothalamus, septohypothalamic nucleus, intermediate subdivision of the lateral septum, central amygdaloid nucleus, and the amygdalohippocampal area in the CD group exposed to an acute challenge when compared to males defeated only once. In contrast, c-fos expression within the anterior and ventromedial nuclei of the hypothalamus, dorsal periaqueductal grey, dorsal raphe, cuneiform nucleus, and locus coeruleus did not differ between AD and CD groups. Similarly, plasma le…

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Authors: Kollack‐Walker, Don, Watson, & Akil
Affiliations: University of Michigan (US)
Corresponding author: Kollack‐Walker
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 1999-07
Volume: 11
Issue: 7
Pages: 547-559
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1046/j.1365-2826.1999.00354.x
OpenAlex: W1567486735
Cited by: 113
References: 59
Citations by year: 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 5 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 7
FWCI: 2.00
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 907 d)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: National Institutes of Health (5p30hd018258-15)
National Institute of Mental Health (P01 MH 42251, P01MH042251)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P-30 HD18258)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: c-fos mRNA, social defeat, chronic stress, immediate early gene expression, hypothalamic paraventricular nucleus, supraoptic nucleus, central amygdala, plasma glucocorticoids, cortisol, corticosterone, hypothalamic-pituitary-adrenal axis, defensive behavior, neuroplasticity, golden hamster
MeSH terms: Aggression, Animals, Behavior, Animal, Brain, Corticosterone, Cricetinae, Hydrocortisone, Male, Mesocricetus, RNA, Messenger, Genes, fos, Genes, Immediate-Early

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Differential Expression of c‐fos mRNA Within Neurocircuits of Male Hamsters Exposed to Acute or Chronic Defeat

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