Social model of depression in mice of C57BL/6J strain
Abstract
Long experience of defeat in daily social intermale confrontations and permanent living with aggressive males under sensory contact conditions [Kudryavtseva (8)] has been shown to produce changes in the patterns of submissive behavior of male mice of C57BL/6J strain. The submissive males after 20 defeats demonstrated passive defense postures instead of active defense and withdrawal which they had displayed in first encounters. Moreover, new immobile postures appeared, which were very rare in the first confrontations. Submissive animals displayed a decrease of ambulation in the open-field test and increase the immobility time in the Porsolt's test. Chronic treatment with imipramine prevented the increase of "depressiveness" estimated by means of the Porsolt's test. There was a loss of weight and some disturbances in gastrointestinal functions. The data are discussed in terms of the development of depression in submissive male C57BL/6J mice as a result of chronic unavoidable social stress.
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Social defeat stress in mice has excellent etiological, predictive, discriminative and face validity.
“When considering experimental approaches for studying depression, social defeat stress, in particular, has been shown to have excellent etiological, predictive, discriminative and face validity.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [10]
A modified and abbreviated version of the sensory contact model of social defeat stress in mice, initially described by Kudryavtseva and co-workers, was introduced in 2006 by Berton et al.
“A modified and abbreviated version of the sensory contact model of social defeat stress in mice, initially described by Kudryavtseva and co-workers10,22, was introduced in 2006 by Berton et al.17.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [10]
Individual responses to social stressors within experimental preparations have become increasingly useful in modeling aspects of depression-like behavior with high construct, face, discriminative and predictive validity.
“Individual responses to social stressors within experimental preparations have thus become increasingly useful in modeling aspects of depression-like behavior with high construct, face, discriminative and predictive validity3,7–11.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [10]
Repeated exposures to social defeat stress in rodents cause a robust depression-like phenotype marked by anhedonia, anxiety and social-avoidance behaviors.
“Repeated exposures to social defeat stress in rodents, for example, cause a robust depression-like phenotype marked by anhedonia, anxiety and social-avoidance behaviors10,14–17.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [10]
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- Authors
- Kudryavtseva, N. N., Bakshtanovskaya, I. V., & Koryakina, L. A.
- Affiliations
- Institute of Cytology and Genetics (RU)
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1991-02
- Volume
- 38
- Issue
- 2
- Pages
- 315-320
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W1991201649
- Cited by
- 404
- References
- 1
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 27 · 2023: 15 · 2022: 17 · 2021: 22 · 2020: 16 · 2019: 18 · 2018: 26 · 2017: 21 · 2016: 21 · 2015: 20 · 2014: 22 · 2013: 8 · 2012: 14
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- social defeat, chronic social stress, depression, submissiveness, C57BL/6J mice, imipramine, passive defense, immobility, open field behavior, gastrointestinal diseases, weight loss
- MeSH terms
- Aggression, Animals, Depression, Disease Models, Animal, Exploratory Behavior, Gastric Mucosa, Gastrointestinal Hemorrhage, Imipramine, Mice, Inbred C57BL, Reaction Time, Social Behavior, Social Dominance, Mice
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