Deviant Forms of Aggression in Glucocorticoid Hyporeactive Rats: A Model for 'Pathological' Aggression?
Abstract
Deviant forms of aggressiveness have been associated with low plasma glucocorticoid concentrations in humans. Here, we report data on the development of aggressive behaviour in rats in which glucocorticoid secretion was inhibited by adrenalectomy. Such rats were compared with both sham operated rats and adrenalectomized rats in which the fight-induced elevation of plasma glucocorticoids was mimicked by acute injections. Low and stable corticosterone plasma concentrations were maintained by subcutaneous glucocorticoid pellets in adrenalectomized rats. The development of aggressive behaviour was followed over three trials performed at 2-day intervals. Adrenalectomy lead to high aggressiveness already at the first encounter, a decreased threatening (attack signalling) behaviour and a change in attack targeting. While control rats targeted biting attacks towards less vulnerable dorsal parts of the opponent's body, adrenalectomized rats attacked the head frequently. Corticosterone injections that mimicked the fight induced adrenocortical reaction abolished this behavioural pattern. Thus, a reduced responsiveness of the adrenocortical system may be causally linked to deviant forms of aggression in rats.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chronic glucocorticoid deficiency induces abnormal aggression in rats.
“In addition, these findings resonate with earlier work by Haller and collaborators in rats showing that chronic glucocorticoid deficiency induces abnormal aggression46–48.”
Cites
Ultradian Corticosterone Rhythm and the Propensity to Behave Aggressively in Male Rats
Haller, J., Halasz, J., Mikics, É., Kruk, M. R., & Makara, G. B. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00568.x · Cited by 73 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Korte, S. M., Koolhaas, J. M., Wingfield, J. C., & McEwen, B. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.009 · Cited by 1,097 · see citing works
The evidence for a neurobiological model of childhood antisocial behavior
van Goozen, S. H. M., Fairchild, G., Snoek, H., & Harold, G. T. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.149 · Cited by 475 · see citing works
Popma, A., Vermeiren, R., Geluk, C. A. M. L., Rinne, T., van den Brink, W., Knol, D. L., Jansen, L. M. C., van Engeland, H., & Doreleijers, T. A. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.006 · Cited by 290 · see citing works
de Boer, S. F., van der Vegt, B. J., & Koolhaas, J. M. (2003) · Behavior Genetics · doi:10.1023/a:1025766415159 · Cited by 219 · see citing works
Murray-Close, D., Han, G., Cicchetti, D., Crick, N. R., & Rogosch, F. A. (2008) · Developmental Psychology · doi:10.1037/a0012564 · Cited by 97 · see citing works
Recent advances in the study of aggression
Flanigan, M. E., & Russo, S. J. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0226-2 · Cited by 75 · see citing works
Walker, S. E., Papilloud, A., Huzard, D., & Sandi, C. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.008 · Cited by 49 · see citing works
Haller, J. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_284 · Cited by 47 · see citing works
Papilloud, A., Guillot de Suduiraut, I., Zanoletti, O., Grosse, J., & Sandi, C. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0215-6 · Cited by 38 · see citing works
- Authors
- Haller, J., van de Schraaf, J., & Kruk, M. R.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- ORCID
- Haller, J.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2001-01
- Volume
- 13
- Issue
- 1
- Pages
- 102-107
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2090348866
- Cited by
- 106
- References
- 1
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 3 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Hungarian Scientific Research Fund
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
- Keywords
- pathological aggression, adrenalectomy, corticosterone, adrenocortical responsiveness, aggression
- MeSH terms
- Adrenalectomy, Aggression, Animals, Anti-Inflammatory Agents, Behavior, Animal, Mental Disorders, Corticosterone, Disease Models, Animal, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
