Ultradian Corticosterone Rhythm and the Propensity to Behave Aggressively in Male Rats
Abstract
Ultradian fluctuations in plasma glucocorticoids have been demonstrated in a variety of species including humans. The significance of such rhythms is poorly known, although disorganized ultradian glucocorticoid rhythms have been associated with behavioural disorders. Here we report that ultradian glucocorticoid rhythms may establish the propensity to behave aggressively in male rats. Male rats were significantly more aggressive in the increasing phase of their corticosterone fluctuation when confronting a male intruder than counterparts in the decreasing phase of their corticosterone fluctuations facing such opponents. Corticosterone fluctuations were mimicked by a combination of treatments with the corticosterone synthesis inhibitor metyrapone and corticosterone. Again, males with increased plasma corticosterone levels were more aggressive than counterparts with a decreased plasma corticosterone concentration. These data suggest that the behavioural response to an aggressive challenge may vary in the same animal across the day due to the pulsating nature of corticosterone secretion. Aggressive behaviour is also episodic in humans; moreover, intermittent explosive behaviour is recognized as a psychological disorder. It can be hypothesized that a temporal coincidence between the occurrence of a challenge and a surge in plasma corticosterone concentration may be one of the factors that promote episodic aggressive outbursts.
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The time-dependent Jacobian results are consistent with rat experiments [16, 17] showing more aggressive behavior when rats are perturbed on the upward slope of corticosterone.
“The time-dependent Jacobian provided insight into experimental phenomena, explaining why rats respond differently to perturbations during corticosterone secretion's upward versus downward slopes.”
From A Novel Use of Pseudospectra in Mathematical Biology: Understanding HPA Axis Sensitivity (2024) · cites this paper as [17]
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Stress hormones and aggression Animal models of human pathologies
Haller, J., & Kruk, M. R. (2001)
Self-citationHamon, M., Bourgoin, S., & Martin, P. A. (2008)
A Novel Use of Pseudospectra in Mathematical Biology: Understanding HPA Axis Sensitivity
Drysdale, C., & Colbrook, M. (2026) · Trends in mathematics · doi:10.1007/978-3-032-02326-1_10
- Authors
- Haller, J., Halasz, J., Mikics, É., Kruk, M. R., & Makara, G. B.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- Leiden University (NL)
- Corresponding author
- Haller, J.
- ORCID
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2000-10
- Volume
- 12
- Issue
- 10
- Pages
- 937-940
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2098550241
- Cited by
- 73
- References
- 36
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 4 · 2014: 10 · 2013: 3 · 2012: 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- ultradian rhythms, corticosterone, glucocorticoids, aggression, male rats, metyrapone, plasma corticosterone, intermittent explosive disorder, diurnal variation
- MeSH terms
- Activity Cycles, Aggression, Animals, Behavior, Animal, Corticosterone, Drug Synergism, Male, Oscillometry, Osmolar Concentration, Pyridines, Rats
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