The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF‐α production and downregulation of the MAP kinases p38 and JNK
Abstract
Exposure of macrophages to lipopolysaccharide (LPS) leads to production of the pro‐inflammatory cytokine, tumour necrosis factor alpha (TNF‐α). Previous studies have suggested that pathogenic Yersinia spp. inhibit LPS‐mediated production of TNF‐α in macrophages, and that one of the Yop proteins secreted by the plasmid‐encoded type III pathway is required for this activity. We found that TNF‐α production was inhibited when J774A.1 murine macrophages were infected with wild‐type Y. pseudotuberculosis but not with an isogenic ysc mutant defective for Yop secretion. We inactivated multiple yop genes to identify which of these factors are required for the inhibition of TNF‐α production. A mutant unable to express yopJ was defective for the inhibition of TNF‐α production. Production of TNF‐α is regulated at the transcriptional and translational levels by several mitogen‐activated protein (MAP) kinases. The MAP kinases p38 and JNK underwent sustained activation in macrophages infected with the yopJ mutant. Conversely, p38 and JNK were downregulated in macrophages infected with the wild‐type strain. The ability of the yopJ mutant to downregulate p38 and JNK and to inhibit production of TNF‐α was restored by the expression of yopJ+in trans. Therefore, YopJ is required for Y. pseudotuberculosis to downregulate MAP kinases and inhibit the production of TNF‐α in macrophages.
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Cites
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Cited by
Disruption of Signaling by Yersinia Effector YopJ, a Ubiquitin-Like Protein Protease
Orth, K., Xu, Z., Mudgett, M. B., Bao, Z. Q., Palmer, L. E., Bliska, J. B., Mangel, W. F., Staskawicz, B., & Dixon, J. E. (2000) · Science · doi:10.1126/science.290.5496.1594 · Cited by 542
Self-citationThe Yersinia Ysc–Yop 'Type III' weaponry
Cornelis, G. R. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm932 · Cited by 422
The Induction of Apoptosis by Bacterial Pathogens
Weinrauch, Y., & Zychlinsky, A. (1999) · Annual Review of Microbiology · doi:10.1146/annurev.micro.53.1.155 · Cited by 414
Casson, C. N., Yu, J., Reyes, V. M., Taschuk, F. O., Yadav, A., Copenhaver, A. M., Nguyen, H. T., Collman, R. G., & Shin, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421699112 · Cited by 276
Bergsbaken, T., & Bevan, M. J. (2015) · Nature Immunology · doi:10.1038/ni.3108 · Cited by 274
Metadata
- Authors
- Palmer, L. E., Hobbie, S., Galán, J. E., & Bliska, J. B.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1998-03
- Volume
- 27
- Issue
- 5
- Pages
- 953-965
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2129319176
- Cited by
- 300
- References
- 49
- FWCI
- 13.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Palmer, L. E., Hobbie, S., Galán, J. E., & Bliska, J. B. (1998). YopJ of Yersinia pseudotuberculosis is required for the inhibition of macrophage TNF‐α production and downregulation of the MAP kinases p38 and JNK. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.1998.00740.x
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