Cited by 163Tuberculosis Research and EpidemiologyBacterial Genetics and BiotechnologyIron Metabolism and Disorders

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Mechanisms of iron regulation in mycobacteria: role in physiology and virulence

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Rodriguez, G. Marcela, Smith, Issar·2003·Molecular Microbiology

DOI 10.1046/j.1365-2958.2003.03384.x

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Abstract

Summary: The role of iron in mycobacteria as in other bacteria goes beyond the need for this essential cofactor. Limitation of this metal triggers an extensive response aimed at increasing iron acquisition while coping with iron deficiency. In contrast, iron‐rich environments prompt these prokaryotes to induce synthesis of iron storage molecules and to increase mechanisms of protection against iron‐mediated oxidative damage. The response to changes in iron availability is strictly regulated in order to maintain sufficient but not excessive and potentially toxic levels of iron in the cell. This response is also linked to other important processes such as protection against oxidative stress and virulence. In bacteria, iron metabolism is regulated by controlling transcription of genes involved in iron uptake, transport and storage. In mycobacteria, this role is fulfilled by the i ron‐d ependent r egulator IdeR. IdeR is an essential protein in Mycobacterium tuberculosis, the causative agent of human tuberculosis. It functions as a repressor of iron acquisition genes, but is also an activator of iron storage genes and a positive regulator of oxidative stress responses.

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Authors: Rodriguez, G. M., & Smith, I.
Affiliations: International Center for Public Health (US)
Corresponding author: Smith, Issar
Venue: Molecular Microbiology
Publisher: Wiley
Published: 2003-03
Volume: 47
Issue: 6
Pages: 1485-1494
ISSN: 0950-382X (ISSN-L)
1365-2958
DOI: 10.1046/j.1365-2958.2003.03384.x
OpenAlex: W2156343505
Cited by: 162
References: 81
Citations by year: 2026: 4 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 6 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 5
FWCI: 2.09
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4 d)
Locations: Molecular Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL64544, R01HL064544)
National Institute of Allergy and Infectious Diseases (AI-44856)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: iron regulation, mycobacteria, Mycobacterium tuberculosis, IdeR, iron acquisition, iron storage, oxidative stress response, virulence, iron deficiency, transcriptional regulation
MeSH terms: Iron, Mycobacterium, Virulence, Gene Expression Regulation, Bacterial, Oxidative Stress, Feedback, Physiological

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Mechanisms of iron regulation in mycobacteria: role in physiology and virulence

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