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Vacuolar cation/H+ exchange, ion homeostasis, and leaf development are altered in a T‐DNA insertional mutant of AtNHX1, the Arabidopsis vacuolar Na+/H+ antiporter
Abstract
Summary: The function of vacuolar Na+/H+ antiporter(s) in plants has been studied primarily in the context of salinity tolerance. By facilitating the accumulation of Na+ away from the cytosol, plant cells can avert ion toxicity and also utilize vacuolar Na+ as osmoticum to maintain turgor. As many genes encoding these antiporters have been cloned from salt‐sensitive plants, it is likely that they function in some capacity other than salinity tolerance. The wide expression pattern of Arabidopsis thaliana sodium proton exchanger 1 (AtNHX1) in this study supports this hypothesis. Here, we report the isolation of a T‐DNA insertional mutant of AtNHX1, a vacuolar Na+/H+ antiporter in Arabidopsis. Vacuoles isolated from leaves of the nhx1 plants had a much lower Na+/H+ and K+/H+ exchange activity. nhx1 plants also showed an altered leaf development, with reduction in the frequency of large epidermal cells and a reduction in overall leaf area compared to wild‐type plants. The overexpression of AtNHX1 in the nhx1 background complemented these phenotypes. In the presence of NaCl, nhx1 seedling establishment was impaired. These results place AtNHX1 as the dominant K+ and Na+/H+ antiporter in leaf vacuoles in Arabidopsis and also suggest that its contribution to ion homeostasis is important for not only salinity tolerance but development as well.
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Cites
A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis
Long, J. A., Moan, E. I., Medford, J. I., & Barton, M. K. (1996) · Nature · doi:10.1038/379066a0 · Cited by 1,537
Cited by
Elucidating the molecular mechanisms mediating plant salt‐stress responses
Yang, Y., & Guo, Y. (2018) · New Phytologist · doi:10.1111/nph.14920 · Cited by 1,631
Plants’ Response Mechanisms to Salinity Stress
Balasubramaniam, T., Shen, G., Esmaeili, N., & Zhang, H. (2023) · Plants · doi:10.3390/plants12122253 · Cited by 740
Bassil, E., Tajima, H., Liang, Y.-C., Ohto, M.-A., Ushijima, K., Nakano, R., Esumi, T., Coku, A., Belmonte, M., & Blumwald, E. (2011) · The Plant Cell · doi:10.1105/tpc.111.089581 · Cited by 470
Self-citationPotassium and phosphorus transport and signaling in plants
Wang, Y., Chen, Y., & Wu, W. (2021) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13053 · Cited by 431
Identification of a novel salt tolerance gene in wild soybean by whole-genome sequencing
Qi, X., Li, M.-W., Xie, M., Liu, X., Ni, M., Shao, G., Song, C., Kay-Yuen Yim, A., Tao, Y., Wong, F.-L., et al. (2014) · Nature Communications · doi:10.1038/ncomms5340 · Cited by 408
Metadata
- Authors
- Apse, M. P., Sottosanto, J. B., & Blumwald, E.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2003-09-15
- Volume
- 36
- Issue
- 2
- Pages
- 229-239
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W2061145565
- Cited by
- 365
- References
- 1
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Apse, M. P., Sottosanto, J. B., & Blumwald, E. (2003). Vacuolar cation/H+ exchange, ion homeostasis, and leaf development are altered in a T‐DNA insertional mutant of AtNHX1, the Arabidopsis vacuolar Na+/H+ antiporter. The Plant Journal. https://doi.org/10.1046/j.1365-313x.2003.01871.x
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