Cited by 147Viral Infectious Diseases and Gene Expression in InsectsVirus-based gene therapy researchRNA Interference and Gene Delivery

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Episomal vectors for gene expression in mammalian cells

Van Craenenbroeck, Kathleen, Vanhoenacker, Peter, Haegeman, Guy·2000·European Journal of Biochemistry

DOI 10.1046/j.1432-1327.2000.01645.x

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Abstract

An important reason for preferring mammalian cells for heterologous gene expression is their ability to make authentic proteins containing post‐translational modifications similar to those of the native protein. The development of expression systems for mammalian cells has been ongoing for several years, resulting in a wide variety of effective expression vectors. The aim of this review is to highlight episomal expression vectors. Such episomal plasmids are usually based on sequences from DNA viruses, such as BK virus, bovine papilloma virus 1 and Epstein–Barr virus. In this review we will mainly focus on the improvements made towards the usefulness of these systems for gene expression studies and gene therapy.

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Authors: Van Craenenbroeck, K., Vanhoenacker, P., & Haegeman, G.
Affiliations: Vlaams Instituut voor Biotechnologie (BE)
Corresponding author: Haegeman, Guy
Venue: European Journal of Biochemistry
Publisher: Wiley
Published: 2000-09
Volume: 267
Issue: 18
Pages: 5665-5678
ISSN: 0014-2956 (ISSN-L)
1432-1033
DOI: 10.1046/j.1432-1327.2000.01645.x
OpenAlex: W1591316509
Cited by: 147
References: 194
Citations by year: 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 12 · 2016: 7 · 2015: 11 · 2014: 7 · 2013: 6 · 2012: 5
FWCI: 0.25
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 480 d)
Locations: European Journal of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords: episomal vectors, mammalian cell expression systems, heterologous expression, BK virus, bovine papillomavirus 1, Epstein-Barr virus, post-translational modification, gene therapy
MeSH terms: Animals, BK Virus, Cell Line, Herpesvirus 4, Human, Genetic Vectors, Humans, Models, Genetic, Plasmids, Genetic Therapy, Gene Transfer Techniques, Transgenes, Bovine papillomavirus 1

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Episomal vectors for gene expression in mammalian cells

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