Equine Herpesvirus Type 1 (EHV‐1) Myeloencephalopathy: a Case Report
Open accessAbstract
An outbreak of neurological disease occurred in a well‐managed riding school. Ataxia and paresis were observed in several horses, five of which became recumbent and were euthanized. Post‐mortem analysis revealed scattered haemorrhages along the spinal cord, that were reflected by multiple haemorrhagic foci on formalin‐fixed sections, with the thoracic and lumbar segments being the most affected. Pathohistologically, perivascular mononuclear cuffing and axonal swelling, especially in the white matter, were evident. Parallel to the course of disease, alterations in myelin sheets and activation of astrocytes and microglial cells were also observed. Virological findings confirmed an acute equine herpesvirus type 1 infection and virus was isolated from the spinal cord of a 26‐year‐old mare.
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EHV-1 infection of endothelial cells also induced extravasation of mononuclear cells, resulting in perivascular cuffing and local hemorrhage.
“EHV-1 infection of endothelial cells also induced extravasation of mononuclear cells, resulting in perivascular cuffing and local hemorrhage (50).”
From Equine Herpesvirus Type 1 Enhances Viral Replication in CD172a <sup>+</sup> Monocytic Cells upon Adhesion to Endothelial Cells (2015) · cites this paper as [50]
The Pathohistology section reports perivascular mononuclear cuffing and hemorrhagic areas, and suggests that vascular endothelium is an initial site of EHV-1 replication in the CNS. It does not establish that endothelial infection induced mononuclear-cell extravasation or caused the cuffing and hemorrhage; the claim states that causal sequence more definitively than the paper does. (LLM, conf=0.86)
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- Authors
- STIERSTORFER, B., EICHHORN, W., SCHMAHL, W., BRANDMÜLLER, C., KAADEN, O. ‐., & NEUBAUER, A.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- ORCID
- STIERSTORFER, B.
- Venue
- Journal of Veterinary Medicine, Series B
- Publisher
- Wiley
- Published
- 2002-02
- Volume
- 49
- Issue
- 1
- Pages
- 37-41
- ISSN
- 0931-1793 (ISSN-L)
- OpenAlex
- W2080203891
- Cited by
- 41
- References
- 35
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2019: 3 · 2016: 2 · 2015: 3 · 2014: 1 · 2012: 3
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Veterinary Medicine Series B (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Veterinary › Equine › Veterinary Equine Medical Research
- Keywords
- equine herpesvirus 1, myeloencephalopathy, horses, ataxia, paresis, spinal cord hemorrhage, axonal swellings, astrocyte activation, microglial activation, mares, virus isolation
- MeSH terms
- Animals, Brain, Diagnosis, Differential, Disease Outbreaks, DNA, Viral, Encephalomyelitis, Herpesvirus 1, Equid, Female, Fluorescent Antibody Technique, Germany, Herpesviridae Infections, Horse Diseases, Horses, Immunohistochemistry, Male, Spinal Cord, Polymerase Chain Reaction, Gait Ataxia
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