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Cited by 527

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

History of Depression as a Risk Factor for Dementia: An Updated Review

Open access
Jorm, Anthony F.·2001·Australian & New Zealand Journal of Psychiatry

Abstract

Objective: This review updates an earlier meta-analysis of the data on history of depression as a risk factor for dementia. It also considers the available evidence on the hypotheses proposed to explain the association between history of depression and dementia. Method: A meta-analysis was carried out on results from seven case-control and six prospective studies. A qualitative review was carried out on the evidence related to the hypotheses to explain the association. Results: The meta-analysis found evidence to support an association from both casecontrol studies (estimated relative risk 2.01; 95%% CI 1.16–3.50) and prospective studies (estimated relative risk 1.87; 95%% CI 1.09–3.20). However, the evidence did not clearly support any one hypothesis explaining the association. The most likely contenders are: (i) depression can be an early prodrome of dementia, (ii) depression brings forward the clinical manifestation of dementing diseases, and (iii) depression leads to damage to the hippocampus through a glucocorticoid cascade. Conclusions: The possibility that history of depression is a risk factor for dementia needs to be taken seriously and explanations of the association need to be further researched.

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Crossref · 10.1046/j.1440-1614.2001.00967.x

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Metadata

Authors
Jorm, A. F.
Venue
Australian & New Zealand Journal of Psychiatry
Published
2001-12
Volume
35
Issue
6
Pages
776-781
ISSN
  • 0004-8674 (ISSN-L)
  • 1440-1614
OpenAlex
W2165279131
Cited by
527
References
8
FWCI
2.84
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: History of Depression as a Risk Factor for Dementia: An Updated Review. https://app.cochat.ai/papers/10.1046/j.1440-1614.2001.00967.x
The paper
Jorm, A. F. (2001). History of Depression as a Risk Factor for Dementia: An Updated Review. Australian & New Zealand Journal of Psychiatry. https://doi.org/10.1046/j.1440-1614.2001.00967.x

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.