Vascular aspects in Alzheimer’s disease
Abstract
Alzheimer's disease is a primary degenerative dementia and is not considered to be of vascular origin. Furthermore, severe cerebrovascular diseases are generally exclusionary for the clinical diagnosis. During recent years both epidemiological and neuropathological studies have suggested an association between Alzheimer's disease and several vascular risk factors, such as hypertension, inheritance of the apolipoprotein E epsilon4 allele, coronary heart disease, diabetes mellitus, ischaemic white matter lesions and generalised atherosclerosis. These findings may reflect an overdiagnosis of Alzheimer's disease in individuals with silent cerebrovascular disease or that cerebrovascular disease may affects the clinical expression of Alzheimer's disease. Further possibilities include that Alzheimer's disease may increase the risk of vascular disease or that vascular disease may stimulate the Alzheimer's disease process. Similar mechanisms may also be involved in the pathogenesis of both disorders, such as disturbances in the renin-angiotensin system, apoptosis, and psychological stress.
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Vascular and neurodegenerative processes may interact, so risk factors for cerebrovascular disease also increase the risk of AD.
“Furthermore, there is increasing recognition that vascular and neurodegenerative processes may interact, so that risk factors for CVD also increase the risk of AD.20”
From Diagnostic Criteria for Vascular Cognitive Disorders: A VASCOG Statement (2014) · cites this paper as [20]
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- Authors
- Skoog, I.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Corresponding author
- Skoog, Ingmar
- ORCID
- Skoog, Ingmar
- Venue
- Advances in Dementia Research
- Publisher
- Springer Vienna
- Published
- 2000
- Volume
- 59
- Pages
- 37-43
- OpenAlex
- W2239586493
- Cited by
- 71
- References
- 40
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 4 · 2012: 1
- FWCI
- 19.65
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Springer eBooks (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, vascular risk factors, cerebrovascular disease, hypertension, APOE ε4, coronary artery disease, diabetes mellitus, white matter lesions, atherosclerosis, overdiagnosis, renin-angiotensin system, apoptosis, psychological stress, dementia pathogenesis
- MeSH terms
- Alzheimer Disease, Cerebrovascular Disorders, Humans, Risk Factors
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