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Cited by 327Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesAging, Health, and Disability

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The temporal relationship between depressive symptoms and dementia—A community-based prospective study

Chen, Peijun, Ganguli, Mary, Mulsant, Benoit H., DeKosky, Steven T.·1999·Archives of General Psychiatry
DOI 10.1001/archpsyc.56.3.261
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Abstract

Background The temporal relationship between the appearance of depressive symptoms and the clinical onset of dementia and Alzheimer disease was evaluated in a community sample. Methods An original sample of 1366 subjects aged 65 years or older, selected randomly from a rural Pennsylvania community, was cognitively screened at study entry and every 2 years thereafter. A subset of 954 survivors of this cohort without dementia was screened for depressive symptoms at the second and subsequent data-collection waves. A "depression cluster" was identified by the presence of 5 or more depressive symptoms, including depressed mood, at the time of screening. Cognitively impaired subjects and a sample of unimpaired controls underwent standardized clinical evaluation to determine the presence of incident dementia (by DSM-III-R criteria) and probable or possible Alzheimer disease (by criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association) and to estimate the clinical onset of dementia symptoms. Results A highly increased probability of the depression cluster developing existed among subjects following the onset of dementia (15.4% [6/39]) and Alzheimer disease (17.6% [6/34]) compared with subjects without dementia (3.2% [23/712]). The odds ratios, after adjustment for age, sex, education level, and self reported memory loss, for the development of depression were 6.5 (95% confidence interval, 2…

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Crossref · 10.1001/archpsyc.56.3.261

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  • Depression as a risk factor for dementia and depression as a prodromal symptom remain controversial, the causal relation between depression and dementia is difficult to clarify, and previous literature findings are inconsistent.

    “In the pathogenesis of dementia, both ideas that mention depression as a risk factor for dementia and depression as a prodromal symptom remain controversial. It is difficult to clarify the causal relation between depression and dementia, and findings in the previous literature are inconsistent on these issues [10, 38, 39].”

    From Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan (2017) · cites this paper as [39]

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Metadata

Authors
Chen, P., Ganguli, M., Mulsant, B. H., & DeKosky, S. T.
Affiliations
University of Pittsburgh (US)
ORCID
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1999-03-01
Volume
56
Issue
3
Pages
261
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.56.3.261
OpenAlex
W2046506824
Cited by
327
References
3
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 5 · 2017: 16 · 2016: 8 · 2015: 14 · 2014: 11 · 2013: 14 · 2012: 14
FWCI
8.40
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Pittsburgh (AG07562)
  • National Institutes of Health
  • National Institute on Aging (AG00312, R01AG007562, AG00181, U01AG006782)
  • National Institute of Mental Health
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords
depressive symptoms, dementia, Alzheimer's disease, temporal relations, incident dementia, older adults, cognitive impairment, community-dwelling older adults
MeSH terms
Aged, Alzheimer Disease, Cognition Disorders, Dementia, Depressive Disorder, Female, Health Status, Humans, Male, Pennsylvania, Probability, Prospective Studies, Surveys and Questionnaires, Random Allocation, Sampling Studies, Time Factors, Comorbidity, Cluster Analysis, Confidence Intervals, Odds Ratio

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