Effects of bright light on cognitive and sleep–wake (circadian) rhythm disturbances in Alzheimer‐type dementia
Abstract
Twenty‐seven patients with Alzheimer‐type dementia (ATD) were treated with bright light therapy in the morning for four consecutive weeks. The cognitive state of each patient was evaluated with the Mini‐Mental‐State Examination (MMSE) and circadian rhythm with actigram before and after therapy for all of the patients and those of two groups divided by the severity criteria of the Clinical Dementia Rating. The therapy improved the circadian rhythm disturbances. Although the therapy caused no remarkable effects on dementia severity, it improved the MMSE scores, especially in the early stages of ATD. These results suggest that bright light therapy improved the circadian rhythm disturbances and then bettered the cognitive state in early‐stage ATD.
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Morning light therapy may improve circadian rhythms and MMSE, CMAI and BEHAVEAD scores, particularly in the early stages of dementia, and even in severe cases improves circadian and behavioural symptoms, most notably agitation and overall cognitive function.
“some studies indicate that morning light therapy may improve circadian rhythms and Mini-Mental State examination (MMSE), Cohen-Mansfield Agitation Inventory (CMAI) and Behaviour Pathology in AD Rating Scale (BEHAVEAD) scores, particularly in the early stages of dementia, and that, even in severe cases of dementia, it improves circadian and behavioural symptoms, most notably agitation and overall”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [297]
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Wu, L. M., Valdimarsdottir, H. B., Amidi, A., Reid, K. J., Ancoli‐Israel, S., Bovbjerg, K., Fox, R. S., Walker, L., Matharu, A., Kaseda, E. T., et al. (2022) · Journal of Biological Rhythms · doi:10.1177/07487304221107833 · Cited by 10 · see citing works
A field test of a simplified method of estimating circadian stimulus
Babilon, S., Beck, S., & Khanh, T. (2021) · Lighting Research & Technology · doi:10.1177/14771535211044664 · Cited by 10 · see citing works
- Authors
- Yamadera, H., Ito, T., Suzuki, H., Asayama, K., Ito, R., & Endo, S.
- Affiliations
- Nippon Medical School (JP)
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2000-06
- Volume
- 54
- Issue
- 3
- Pages
- 352-353
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W2044512913
- Cited by
- 148
- References
- 4
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 4 · 2023: 12 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 7
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- bright light therapy, Alzheimer-type dementia, circadian rhythm disruption, sleep-wake cycle, cognitive function, dementia severity, early-stage dementia, actigraphy, Mini-Mental State Examination
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Male, Mental Status Schedule, Neuropsychological Tests, Phototherapy, Treatment Outcome, Polysomnography, Sleep Disorders, Circadian Rhythm
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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