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Cited by 117Pain Mechanisms and TreatmentsNerve injury and regenerationPain Management and Treatment

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Adrenergic innervation of rat sensory ganglia following proximal or distal painful sciatic neuropathy: distinct mechanisms revealed by anti‐NGF treatment

Ramer, Matt S., Bisby, Mark A.·1999·European Journal of Neuroscience
DOI 10.1046/j.1460-9568.1999.00491.x
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Abstract

Sympathetic axons invade dorsal root ganglia (DRG) following nerve injury, and activity in the resulting pericellular axonal ‘baskets’ may underlie painful sympathetic–sensory coupling. Sympathetic sprouting into the DRG may be stimulated by nerve growth factor (NGF). To test this hypothesis, we investigated the effect of daily anti‐NGF administration on pain and on sprouting in the DRG induced by chronic sciatic constriction injury (CCI) or L5 spinal nerve ligation (SNL). These models have been shown to differ subtly in the onset of pain behaviours and adrenergic sprouting, and we now demonstrate a fundamental difference in the way sympathetic axons invade the DRG: after CCI, perivascular noradrenergic collaterals sprouted into the DRG in a manner dependent upon peripherally derived NGF. In contrast, after SNL, regenerating sympathetic axons were diverted towards the DRG from the spinal nerve by the obstructing ligature, and this effect was only moderately impeded by anti‐NGF. The differential dependence on anti‐NGF suggests that adrenergic innervation of the DRG after SNL and CCI may reflect regenerative and collateral sprouting, respectively. Pain behaviour was similarly affected: anti‐NGF completely prevented CCI‐induced thermal hyperalgesia and mechanoallodynia, but the same treatment only partly relieved these symptoms following SNL. These differences emphasize that although CCI and SNL may result in similar behavioural abnormalities, the underlying mechanisms may be governed by distinct processes, differentially dependent on peripheral NGF. These mechanistic differences will have to be considered in the development of appropriate treatment strategies for neuropathic pain produced by different types of pathology.

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Crossref · 10.1046/j.1460-9568.1999.00491.x

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Research works printed but not linked: 3

  1. Jänig W., 1991, Towards a New Pharmacotherapy of Pain., 331
  2. Ramer M.S., 1995, Neuropathic pain and sympathetic sprouting in the dorsal root ganglion: the effect of partial nerve injury and NGF. Soc., Neurosci. Abstract., 22, 1809
  3. Thompson S.W.N., 1997, Leukemia inhibitory factor (LIF) induces sympathetic sprouting and pericellular basket formation in intact adult rat sensory ganglia. Soc., Neurosci. Abstract., 23, 1432

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Metadata

Authors
Ramer, M. S., & Bisby, M. A.
Affiliations
Queen's University (CA)
Corresponding author
Ramer, Matt S.
ORCID
Bisby, Mark A.
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
1999-03
Volume
11
Issue
3
Pages
837-846
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1046/j.1460-9568.1999.00491.x
OpenAlex
W1985937673
Cited by
116
References
57
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 3
FWCI
3.54
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1029 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
adrenergic innervation, dorsal root ganglia, nerve growth factor, spinal nerve ligation, painful neuropathy, thermal hyperalgesia
MeSH terms
Adrenergic Fibers, Animals, Antibodies, Behavior, Animal, Ganglia, Spinal, Ligation, Male, Nerve Growth Factors, Nerve Regeneration, Neurons, Afferent, Pain, Receptors, Adrenergic, Sciatic Nerve, Sciatica, Sympathectomy, Wallerian Degeneration, Rats, Sprague-Dawley, Rats

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