The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Endogenous BDNF is required for myelination and regeneration of injured sciatic nerve in rodents
Open accessAbstract
Following a peripheral nerve injury, brain-derived neurotrophic factor (BDNF) and the p75 neurotrophin receptor are upregulated in Schwann cells of the Wallerian degenerating nerves. However, it is not known whether the endogenous BDNF is critical for the functions of Schwann cells and regeneration of injured nerve. Treatment with BDNF antibody was shown to retard the length of the regenerated nerve from injury site by 24%. Histological and ultrastructural examination showed that the number and density of myelinated axons in the distal side of the lesion in the antibody-treated mice was reduced by 83%. In the BDNF antibody-treated animals, there were only distorted and disorganized myelinated fibres in the injured nerve where abnormal Schwann cells and phagocytes were present. As a result of nerve degeneration in BDNF antibody-treated animals, subcellular organelles, such as mitochondria, disappeared or were disorganized and the laminal layers of the myelin sheath were loosened, separated or collapsed. Our in situ hybridization revealed that BDNF mRNA was expressed in Schwann cells in the distal segment of lesioned nerve and in the denervated muscle fibres. These results indicate that Schwann cells and muscle fibres may contribute to the sources of BDNF during regeneration and that the deprivation of endogenous BDNF results in an impairment in regeneration and myelination of regenerating axons. It is concluded that endogenous BDNF is required for peripheral nerve regeneration and remyelination after injury.
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Cites
Physiology of the Neurotrophins
Lewin, G. R., & Barde, Y.-A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001445 · Cited by 1,955
Purification of a new neurotrophic factor from mammalian brain.
Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
Hyman, C., Hofer, M., Barde, Y.-A., Juhasz, M., Yancopoulos, G. D., Squinto, S. P., & Lindsay, R. M. (1991) · Nature · doi:10.1038/350230a0 · Cited by 1,494
Molecular cloning and expression of brain-derived neurotrophic factor
Leibrock, J., Lottspeich, F., Hohn, A., Hofer, M., Hengerer, B., Masiakowski, P., Thoenen, H., & Barde, Y.-A. (1989) · Nature · doi:10.1038/341149a0 · Cited by 1,457
The Trk family of neurotrophin receptors
Barbacid, M. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251107 · Cited by 1,281
Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
Casaccia-Bonnefil, P., Carter, B. D., Dobrowsky, R. T., & Chao, M. V. (1996) · Nature · doi:10.1038/383716a0 · Cited by 764
Meyer, M., Matsuoka, I., Wetmore, C., Olson, L., & Thoenen, H. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.1.45 · Cited by 719
Funakoshi, H., Frisén, J., Barbany, G., Timmusk, T., Zachrisson, O., Verge, V. M., & Persson, H. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.2.455 · Cited by 688
Selective Activation of NF-κB by Nerve Growth Factor Through the Neurotrophin Receptor p75
Carter, B. D., Kaltschmidt, C., Kaltschmidt, B., Offenhäuser, N., Böhm-Matthaei, R., Baeuerle, P. A., & Barde, Y.-A. (1996) · Science · doi:10.1126/science.272.5261.542 · Cited by 658
Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein
Levi-Montalcini, R., & Booker, B. (1960) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.46.3.384 · Cited by 647
Cited by
Why is Wallerian degeneration in the CNS so slow?
Vargas, M. E., & Barres, B. A. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094354 · Cited by 510
Electrical stimulation promotes sensory neuron regeneration and growth-associated gene expression
Geremia, N. M., Gordon, T., Brushart, T. M., Al-Majed, A. A., & Verge, V. M. K. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.01.040 · Cited by 430
The influence of substrate stiffness on the behavior and functions of Schwann cells in culture
Gu, Y., Ji, Y., Zhao, Y., Liu, Y., Ding, F., Gu, X., & Yang, Y. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.006 · Cited by 162
Progesterone treatment of spinal cord injury: effects on receptors, neurotrophins, and myelination
De Nicola, A. F., Gonzalez, S. L., Labombarda, F., Deniselle, M. C. G., Garay, L., Guennoun, R., & Schumacher, M. (2006) · Journal of Molecular Neuroscience · doi:10.1385/jmn:28:1:3 · Cited by 92
MLean, N. A., & Verge, V. M. K. (2016) · Glia · doi:10.1002/glia.23021 · Cited by 62
Metadata
- Authors
- Zhang, J.-Y., Luo, X.-G., Xian, C. J., Liu, Z.-H., & Zhou, X.-F.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2000-12
- Volume
- 12
- Issue
- 12
- Pages
- 4171-4180
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1963594438
- Cited by
- 274
- References
- 40
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, J.-Y., Luo, X.-G., Xian, C. J., Liu, Z.-H., & Zhou, X.-F. (2000). Endogenous BDNF is required for myelination and regeneration of injured sciatic nerve in rodents. European Journal of Neuroscience. https://doi.org/10.1046/j.1460-9568.2000.01312.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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