Why is Wallerian degeneration in the CNS so slow?
Abstract
Wallerian degeneration (WD) is the set of molecular and cellular events by which degenerating axons and myelin are cleared after injury. Why WD is rapid and robust in the PNS but slow and incomplete in the CNS is a longstanding mystery. Here we review current work on the mechanisms of WD with an emphasis on deciphering this mystery and on understanding whether slow WD in the CNS could account for the failure of CNS axons to regenerate.
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Failure to clear myelin debris contributes to CNS regenerative failure.
“Dysregulation of microglial phagocytosis of synapses has been implicated in the pathology of diverse neurological diseases (Hong et al., 2016; Lui et al., 2016; Vasek et al., 2016), failure to clear myelin debris contributes to CNS regenerative failure (Vargas and Barres, 2007), and problems with microglial uptake and clearance may contribute to aging-associated cognitive decline (Safaiyan et al.,”
From Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures (2017) · cites this paper as Vargas and Barres, 2007
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- Authors
- Vargas, M. E., & Barres, B. A.
- Affiliations
- Stanford Medicine (US)
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2007-07-01
- Volume
- 30
- Issue
- 1
- Pages
- 153-179
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2165804706
- Cited by
- 510
- References
- 1
- Citations by year
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- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Wallerian degeneration, central nervous system, peripheral nervous system, axon regeneration, myelin debris clearance, axonal injury, axonal degeneration
- MeSH terms
- Animals, Antibodies, Axons, Central Nervous System Diseases, Humans, Macrophages, Myelin Sheath, Nerve Regeneration, Neuroglia, Phagocytosis, Time Factors, Wallerian Degeneration
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