The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap
Open accessAbstract
The present work was performed to determine the ability of neurotrophic factors to allow axonal regeneration across a 15‐mm‐long gap in the rat sciatic nerve. Synthetic nerve guidance channels slowly releasing NGF and GDNF were fabricated and sutured to the cut ends of the nerve to bridge the gap. After 7 weeks, nerve cables had formed in nine out of ten channels in both the NGF and GDNF groups, while no neuronal cables were present in the control group. The average number of myelinated axons at the midpoint of the regenerated nerves was significantly greater in the presence of GDNF than NGF (4942 ± 1627 vs. 1199 ± 431, P ≤ 0.04). A significantly greater number of neuronal cells in the GDNF group, when compared to the NGF group, retrogradely transported FluoroGold injected distal to the injury site before explantation. The total number of labelled motoneurons observed in the ventral horn of the spinal cord was 98.1 ± 23.4 vs. 20.0 ± 8.5 (P ≤ 0.001) in the presence of GDNF and NGF, respectively. In the dorsal root ganglia, 22.7% ± 4.9% vs. 3.2% ± 1.9% (P ≤ 0.005) of sensory neurons were labelled retrogradely in the GDNF and NGF treatment groups, respectively. The present study demonstrates that, sustained delivery of GDNF and NGF to the injury site, by synthetic nerve guidance channels, allows regeneration of both sensory and motor axons over long gaps; GDNF leads to better overall regeneration in the sciatic nerve.
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Cites
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Cited by
Neural Tissue Engineering: Strategies for Repair and Regeneration
Schmidt, C. E., & Leach, J. B. (2003) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.5.011303.120731 · Cited by 1,237
Peripheral nerve regeneration: Experimental strategies and future perspectives
Faroni, A., Mobasseri, S. A., Kingham, P. J., & Reid, A. J. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.11.010 · Cited by 592
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Effect of modulating macrophage phenotype on peripheral nerve repair
Mokarram, N., Merchant, A., Mukhatyar, V., Patel, G., & Bellamkonda, R. V. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.050 · Cited by 334
Metadata
- Authors
- Fine, E. G., Decosterd, I., Papaloïzos, M., Zurn, A. D., & Aebischer, P.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2002-02
- Volume
- 15
- Issue
- 4
- Pages
- 589-601
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2104950498
- Cited by
- 286
- References
- 66
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Fine, E. G., Decosterd, I., Papaloïzos, M., Zurn, A. D., & Aebischer, P. (2002). GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap. European Journal of Neuroscience. https://doi.org/10.1046/j.1460-9568.2002.01892.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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