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Cited by 113Memory and Neural MechanismsNeural dynamics and brain functionNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Timecourse of object‐related neural activity in the primate prefrontal cortex during a short‐term memory task

Rainer, Gregor, Miller, Earl K.·2002·European Journal of Neuroscience
DOI 10.1046/j.1460-9568.2002.01958.x
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Abstract

We studied the timecourse of neural activity in the primate (Macacca mulatta) prefrontal (PF) cortex during an object delayed‐matching‐to‐sample (DMS) task. To assess the effects of experience on this timecourse, we conducted the task using both novel and highly familiar objects. In addition, noise patterns containing no task‐relevant information were used as samples on some trials. Comparison of average PF ensemble activity relative to baseline activity generated by objects and noise patterns revealed three distinct activity periods. (i) Sample onset elicited a transient sensory visual response. In this sensory period, novel objects elicited stronger average ensemble activity than both familiar objects and noise patterns. (ii) An intermediate period of elevated activity followed, which began before sample offset, and continued well into the delay period. In the intermediate period, activity was elevated for noise patterns and novel objects, but near baseline for familiar objects. (iii) Finally, after average ensemble activity reached baseline activity at the end of the intermediate period, a reactivation period occurred late in the delay. Experience had little effect during reactivation, where activity was elevated for both novel and familiar objects compared to noise patterns. We show that the ensemble average resembles the activity timecourse of many single prefrontal neurons. These results suggest that PF delay activity does not merely maintain recent sensory input, but is subject to more complex experience‐dependent dynamics. This has implications for how delay activity is generated and maintained.

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Metadata

Authors
Rainer, G., & Miller, E. K.
Affiliations
Massachusetts Institute of Technology (US)
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2002-04
Volume
15
Issue
7
Pages
1244-1254
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1046/j.1460-9568.2002.01958.x
OpenAlex
W2076208166
Cited by
113
References
40
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 6
FWCI
3.36
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 29 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
National Institute of Neurological Disorders and Stroke
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
prefrontal cortex, delayed matching-to-sample, short-term memory, delay activity, object familiarity, rhesus monkeys, sensory responses, memory reactivation
MeSH terms
Acoustic Stimulation, Action Potentials, Animals, Auditory Perception, Behavior, Animal, Female, Macaca mulatta, Male, Memory, Short-Term, Neurons, Pattern Recognition, Visual, Photic Stimulation, Psychomotor Performance, Reaction Time, Time Factors, Prefrontal Cortex

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