CoChat
Sign Up
Cited by 167

The DOI matches its Crossref record.

Generation and phenotypic analysis of sigma receptor type I (σ1) knockout mice

Langa, Francina, Codony, Xavier, Tovar, Victoria, Lavado, Alfonso, Giménez, Estela, Cozar, Patricia, Cantero, Marta, Dordal, Albert, Hernández, Enric, Pérez, Raquel, Monroy, Xavier, Zamanillo, Daniel, Guitart, Xavier, Montoliu, Lluís·2003·European Journal of Neuroscience
DOI 10.1046/j.1460-9568.2003.02950.x
Open this paper in CoChat — free account

Abstract

Sigma (σ) sites are a type of nonopiate receptor whose role has been associated with several behaviours, including anxiety, depression, analgesia, learning processes and psychosis. Although there are several known σ receptor types, only the type I receptor (σ1) has been cloned. To uncover the in vivo relevance of σ‐receptors, we have generated knockout mice for σ1. Despite the broad expression pattern found for the σ1‐ gene, homozygous mutant mice are viable, fertile and do not display any overt phenotype, compared with their wild‐type litter‐mates, in mixed genetic backgrounds. However, a significant decrease in the hypermotility response has been measured in knockout mice upon challenge with (+)SKF‐10 047, in agreement with the involvement of σ1‐receptors in the induction of psychostimulant actions. The activity of σ2‐receptors seems to be unaffected in σ1‐mutant mice. These knockout mice could contribute to better understand the in vivo role of σ‐receptors.

Overview

Integrity signals

Registry

Crossref · 10.1046/j.1460-9568.2003.02950.x

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 51

  1. Ausubel F.M., 1999, Current Protocols in Molecular Biology
  2. 10.1016/S0896-6273(00)80958-7 · DOI · Paper page
  3. 10.1016/S0006-8993(99)01602-9 · DOI
  4. 10.1016/S0031-6865(99)00034-5 · DOI
  5. Bultman S., 1999, Gene Targeting. A Practical Approach, 255
  6. 10.1016/0014-2999(88)90362-7 · DOI
  7. Crawley J.N., 2000, What's Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice
  8. 10.1016/0922-4106(92)90153-M · DOI
  9. 10.1124/jpet.301.1.306 · DOI
  10. Ganapathy M.E., 1999, Molecular and ligand‐binding characterization of the sigma‐receptor in the Jurkat human T lymphocyte cell line, J. Pharmacol. Exp. Ther., 289, 251
  11. Gillgan P.J., 1994, Sigma receptor ligands: potential drugs for the treatment of CNS disorders?, Drug News Prespectives, 7, 13
  12. Guitart X., 2003, Sigma Receptors: Chemistry, Cell Biology, and Clinical Implications
  13. 10.1073/pnas.93.15.8072 · DOI
  14. 10.1016/0922-4106(94)90115-5 · DOI · Paper page
  15. 10.1016/S0014-2999(96)00702-9 · DOI
  16. 10.1016/S0304-3940(98)00797-6 · DOI
  17. Joyner A.L., 1999, Gene Targeting. A Practical Approach, 10.1093/oso/9780199637928.001.0001 · DOI
  18. 10.1016/0378-1119(94)90234-8 · DOI
  19. Kaufman M.H., 1995, The Atlas of Mouse Development
  20. 10.1006/bbrc.1996.1842 · DOI
  21. 10.1016/0014-2999(88)90527-4 · DOI
  22. 10.1093/emboj/19.13.3496 · DOI
  23. 10.1016/0092-8674(81)90152-5 · DOI
  24. 10.1016/S0021-9258(19)52451-6 · DOI
  25. 10.1038/ng1197-280 · DOI
  26. 10.1254/jjp.81.125 · DOI
  27. McCann D.J., 1991, Solubilization and characterization of haloperidol‐sensitive (+)‐[3H]SKF‐10,047 binding sites (sigma sites) from rat liver membranes, J. Pharmacol. Exp. Ther., 257, 547
  28. 10.1016/0160-5402(85)90034-8 · DOI
  29. 10.1046/j.1472-8206.2002.00063.x · DOI
  30. 10.1002/j.1460-2075.1996.tb00991.x · DOI
  31. 10.1038/35056009 · DOI
  32. 10.1073/pnas.90.18.8424 · DOI
  33. Novakova M., 1998, Sigma receptors: with special reference to cardiac muscle, Exp. Clin. Cardiol., 3, 113
  34. 10.1002/(SICI)1096-8628(20000207)96:1<118::AID-AJMG23>3.0.CO;2-C · DOI
  35. 10.1046/j.1471-4159.1998.70020443.x · DOI
  36. 10.1016/0165-6147(92)90030-A · DOI
  37. 10.1021/jm00114a015 · DOI
  38. 10.1210/en.136.3.924 · DOI
  39. 10.1046/j.1471-4159.1998.70030922.x · DOI
  40. 10.1006/bbrc.1997.7840 · DOI
  41. 10.1016/S0169-328X(01)00249-2 · DOI
  42. Silver L.M., 1995, Mouse Genetics. Concepts and Applications, 10.1093/oso/9780195075540.001.0001 · DOI
  43. 10.1126/science.2832949 · DOI
  44. 10.1016/0014-2999(96)00109-4 · DOI
  45. 10.1007/978-3-642-80343-7_16 · DOI
  46. 10.1016/0092-8674(91)90011-M · DOI
  47. Vilner B.J., 1995, Sigma‐1 and sigma‐2 receptors are expressed in a wide variety of human and rodent tumor cell lines, Cancer Res., 55, 408
  48. Walker J.M., 1990, Sigma receptors: biology and function, Pharmacol. Rev., 42, 355
  49. 10.1016/0006-3223(91)90209-5 · DOI
  50. 10.1016/0076-6879(93)25025-W · DOI
  51. 10.1016/S0304-3940(00)00884-3 · DOI

Cited by

Sorted by citations

Metadata

Authors
Langa, F., Codony, X., Tovar, V., Lavado, A., Giménez, E., Cozar, P., Cantero, M., Dordal, A., Hernández, E., Pérez, R., Monroy, X., Zamanillo, D., Guitart, X., & Montoliu, L.
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2003-10
Volume
18
Issue
8
Pages
2188-2196
ISSN
  • 0953-816X
  • 1460-9568
DOI
10.1046/j.1460-9568.2003.02950.x
Cited by
167
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 21 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review