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Sigma Receptors Inhibit High-Voltage–Activated Calcium Channels in Rat Sympathetic and Parasympathetic Neurons

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Structural Features Important for .sigma.1 Receptor Binding

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High affinity of sigma1‐binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8–C7 isomerase

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Membrane‐delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G‐protein nor ATP

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Identification of Regions of the σ-1 Receptor Ligand Binding Site Using a Novel Photoprobe

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σ Receptor Activation Blocks Potassium Channels and Depresses Neuroexcitability in Rat Intracardiac Neurons

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Characterization of the Cocaine Binding Site on the Sigma-1 Receptor

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Sigma Receptor Photolabeling and Sigma Receptor-mediated Modulation of Potassium Channels in Tumor Cells

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K+ channel modulation in rodent neurohypophysial nerve terminals by sigma receptors and not by dopamine receptors

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Correlation between neuroleptic binding to σ1 and σ2 receptors and acute dystonic reactions

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(125I)iodoazidococaine, a photoaffinity label for the haloperidol-sensitive sigma receptor.

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BEHAVIOURAL CHANGES INDUCED BY N,N‐DIMETHYLTRYPTAMINE IN RODENTS

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Inhibition of potassium currents by the sigma receptor ligand (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine in sympathetic neurons of the mouse isolated hypogastric ganglion

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Ontogeny of N,N-Dimethyltryptamine and related indolealkylamine levels in neonatal rats

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In Vivo Modulation of Sigma Receptor Sites by Calcitonin Gene‐related Peptide in the Mouse and Rat Hippocampal Formation: Radioligand Binding and Electrophysiological Studies

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Predicting new molecular targets for known drugs

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Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

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The pharmacology of sigma-1 receptors.

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Shaping the interaction landscape of bioactive molecules

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The sigma-1 receptor chaperone as an inter-organelle signaling modulator

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The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network

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A mutation in sigma‐1 receptor causes juvenile amyotrophic lateral sclerosis

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Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens

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From drugs to deprivation: A Bayesian framework for understanding models of psychosis

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TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity

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Novel psychoactive substances of interest for psychiatry

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Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival.

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Recent advances in the neuropsychopharmacology of serotonergic hallucinogens

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Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years

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The hallucinogenic world of tryptamines: an updated review

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Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis

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Neuropharmacology of N,N-dimethyltryptamine

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Targeted anticancer therapy: Overexpressed receptors and nanotechnology

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Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation

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The sigma-1 receptor: roles in neuronal plasticity and disease

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The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization

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Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

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Ayahuasca: pharmacology, neuroscience and therapeutic potential

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Detergent-Resistant Microdomains Determine the Localization of σ-1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction

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Exploring the therapeutic potential of Ayahuasca: acute intake increases mindfulness-related capacities

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Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders

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Clinical applications of hallucinogens: a review

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Neuropharmacology of New Psychoactive Substances (NPS): Focus on the Rewarding and Reinforcing Properties of Cannabimimetics and Amphetamine-Like Stimulants

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Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells

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Ayahuasca: Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness

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N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function

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The Molecular Function of σ Receptors: Past, Present, and Future

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Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans

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The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements.

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The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study

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Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury

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Exploratory study of the dose-related safety, tolerability, and efficacy of dimethyltryptamine (DMT) in healthy volunteers and major depressive disorder

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Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway

Tsai, S., Hayashi, T., Harvey, B. K., Wang, Y., Wu, W. W., Shen, R., Zhang, Y., Becker, K. G., Hoffer, B. J., & Su, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909089106 · Cited by 160 · see citing works

Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities

Szabo, A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00358 · Cited by 150 · see citing works

Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor κB

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A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010.

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The σ2 Receptor: A Novel Protein for the Imaging and Treatment of Cancer

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Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter

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Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

Dakic, V., Minardi Nascimento, J., Costa Sartore, R., Maciel, R. D. M., de Araujo, D. B., Ribeiro, S., Martins-de-Souza, D., & Rehen, S. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-12779-5 · Cited by 134 · see citing works

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

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Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases

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Developments in harmine pharmacology — Implications for ayahuasca use and drug-dependence treatment

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Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc−, the Na+-independent glutamate–cystine exchanger

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The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases

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Sigma receptors: Potential targets for a new class of antidepressant drug

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Structure and therapeutic uses of butyrylcholinesterase: Application in detoxification, Alzheimer's disease, and fat metabolism

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The endogenous hallucinogen and trace amine N.N-dimethyltryptamine (DMT) displays potent protective effects against hypoxia via sigma-1 receptor activation in human primary iPSC-derived cortical neurons and microglia-like immune cells

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Biochemical Pharmacology of the Sigma-1 Receptor

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Sigma receptors [σRs]: biology in normal and diseased states

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Subacute effects of the psychedelic ayahuasca on the salience and default mode networks

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Toxicokinetics and Toxicodynamics of Ayahuasca alkaloids N,N-dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: clinical and forensic impact

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Dark Classics in Chemical Neuroscience:N,N-Dimethyltryptamine (DMT)

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Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope

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N,N-dimethyltryptamine reduces infarct size and improves functional recovery following transient focal brain ischemia in rats

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Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process

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The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes

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Regulation of σ-1 Receptors and Endoplasmic Reticulum Chaperones in the Brain of Methamphetamine Self-Administering Rats

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Protein‐Rich Biomass Waste as a Resource for Future Biorefineries: State of the Art, Challenges, and Opportunities

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Antagonism of Sigma-1 Receptors Blocks Compulsive-Like Eating

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Characterization of the Human Sigma-1 Receptor Chaperone Domain Structure and Binding Immunoglobulin Protein (BiP) Interactions

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Sigma1 Pharmacology in the Context of Cancer

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Role of the Sigma-1 receptor in Amyotrophic Lateral Sclerosis (ALS)

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Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration

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Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders

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